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High SHC3 expression is associated with glioblastoma.
Rai (ShcC/N-Shc), a member of the family of Shc (show SHC1 Proteins)-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells.
Polymorphism in RAI (show RNH1 Proteins) and CD3EAP (show CD3EAP Proteins) are associated with outcome of myeloma patients treated with high dose treatment.
amplification of SHC3 and EDG3 (show S1PR3 Proteins) genes suggests that the two proteins co-operate and are important for ependymomas in vivo.
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc (show SHC1 Proteins).
ALK-ShcC signal activation, possibly caused by co-amplification with the N-myc gene, might give additional effects on malignant tumor progression of neuroblastoma.ShcC is a potent substrate of the activated ALK kinase.
The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret (show RET Proteins) to the phosphatidylinositol 3-kinase/Akt (show AKT1 Proteins) signaling pathway.
ShcC has phosphotyrosine-dependent and -independent functions in neuroblastoma (show ARHGEF16 Proteins) cells
The inappropriate in vivo expression of Shc3 in high-grade glioma may contribute to the survival of the cancer cells.
data suggest that RAI (ShcC/H-Shc (show SHC1 Proteins))is a critical substrate for RET (show RET Proteins) oncoproteins in thyroid carcinomas
Rai interferes with the TCR signaling cascade one of the earliest steps--recruitment of the initiating kinase ZAP-70 (show ZAP70 Proteins) to the phosphorylated subunit of the TCR/CD3 (show CD3E Proteins) complex.
TrkB (show NTRK2 Proteins)-mediated ERK1/2 activation is impaired in huntingtin (show HTT Proteins) knock-in striatal cells involves reduced p52 (show GTF2H4 Proteins)/p46 (show POLDIP3 Proteins) Shc (show SHC1 Proteins) expression
binds the Trk (show NTRK1 Proteins) receptors in a phosphotyrosine-dependent manner via their N-terminal phosphotyrosine binding domain
Rai has a functional neuroprotective role in brain injury, with possible implications in the treatment of stroke
ShcC mediates TrkB (show NTRK2 Proteins)-Ras/MAPK (show MAPK1 Proteins) signaling & regulates NMDA receptor function in the hippocampus via interaction with phosphotyrosines on the receptor subunits. It serves as a modulator of hippocampal synaptic plasticity underlying learning & memory.
Expressed in T and B cells; loss of Rai results in breaking of immunological tolerance and development of systemic autoimmunity.
study reports co-localization of adaptor proteins nShc & Grb10 (show GRB10 Proteins), with Kv1.3 (show KCNA3 Proteins) channel in the olfactory bulb neural lamina; BDNF (show BDNF Proteins)-induced current suppression of the Kv1.3 (show KCNA3 Proteins) channel was prevented by both nShc and Grb10 (show GRB10 Proteins)
may be involved in brain-derived neurotrophic factor signalling during retinal development
SH2 domain protein C3
, SHC-transforming protein 3
, SHC-transforming protein C
, neuronal Shc
, protein Rai
, src homology 2 domain-containing transforming protein C3
, src homology 2 domain-containing-transforming protein C3