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anti-Mouse (Murine) SOS1 antibody for Western Blotting

Recommended SOS1 Antibody (supplied by: Log in to see )

Antigen
Son of Sevenless Homolog 1 (Drosophila) (SOS1) Antibodies
  • 4430401P03Rik
  • 9630010N06
  • AI449023
  • GF1
  • GGF1
  • GINGF
  • HGF
  • NS4
Reactivity
Human, Mouse (Murine)
48
27
9
7
3
1
1
1
1
1
1
Host
Mouse
33
17
7
Clonality
Monoclonal
Conjugate
This SOS1 antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
41
21
21
13
6
5
3
1
Supplier
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Catalog No. ABIN238504
$ 286.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.13397987 ABIN967740 IF IP IHC WB Mouse IgG1 AA 1-109 Log in to see 25-SOS1 5
0.13397987 ABIN967741 IF IP IHC WB Mouse IgG1 AA 1-109 Log in to see 25-SOS1 5
0.13397987 ABIN2789455 WB Rabbit N-Term Log in to see Polyclonal
0.13397987 ABIN2476553 IF ELISA WB Mouse IgG1 Log in to see SOS-01 1
0.0011731815 ABIN1495253 WB Rabbit N-Term Log in to see Polyclonal
0.0011731815 ABIN2737574 WB Rabbit IgG Log in to see Polyclonal
0.0011731815 ABIN1092729 ELISA WB Rabbit IgG Log in to see Polyclonal
0.0011731815 ABIN1092730 ELISA WB Rabbit IgG Log in to see Polyclonal
0.0011731815 ABIN2364688 IP WB Rabbit IgG AA 1243-1258 Log in to see Polyclonal
0.0011731815 ABIN4355179 ICC IF WB DyLight 350 Mouse IgG1 Log in to see SOS-01
0.0011731815 ABIN4355180 ICC IF WB DyLight 405 Mouse IgG1 Log in to see SOS-01
0.0011731815 ABIN4355181 ICC IF WB PE Mouse IgG1 Log in to see SOS-01
0.0011731815 ABIN4355182 ICC IF WB PerCP Mouse IgG1 Log in to see SOS-01
0.0011731815 ABIN4355183 ICC IF WB Allophycocyanin Mouse IgG1 Log in to see SOS-01
0.0011731815 ABIN4355184 ICC IF WB DyLight 755 Mouse IgG1 Log in to see SOS-01
0.0011731815 ABIN4355185 ICC IF WB DyLight 680 Mouse IgG1 Log in to see SOS-01
0.0011731815 ABIN4355186 ICC IF WB DyLight 488 Mouse IgG1 Log in to see SOS-01
0.0011731815 ABIN4355187 ICC IF WB DyLight 405LS Mouse IgG1 Log in to see SOS-01
0.0011731815 ABIN4355188 ICC IF WB Alexa Fluor 405 Mouse IgG1 Log in to see SOS-01
0.0011731815 ABIN4355189 ICC IF WB Alexa Fluor 488 Mouse IgG1 Log in to see SOS-01

Top referenced anti-SOS1 antibody for Western Blotting

Similar anti-SOS1 Antibodies

Application / Reactivity Mouse (Murine) Human
ELISA 3 Antibodies 16 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies 1 Antibodies
Immunocytochemistry (ICC) 13 Antibodies 14 Antibodies
Immunofluorescence (IF) 17 Antibodies 23 Antibodies
Immunohistochemistry (IHC) 2 Antibodies 3 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 2 Antibodies 5 Antibodies
Immunoprecipitation (IP) 3 Antibodies 7 Antibodies
Western Blotting (WB) 24 Antibodies 39 Antibodies
Proximity Ligation Assay (PLA) 1 Antibodies

General

Antigen Son of Sevenless Homolog 1 (Drosophila) (SOS1) Antibodies
Reactivity Human, Mouse (Murine)
(48), (27), (9), (7), (3), (1), (1), (1), (1), (1), (1)
Host Mouse
(33), (17), (7)
Clonality (Clone)
Monoclonal   ( )
Conjugate This SOS1 antibody is un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
(41), (21), (21), (13), (6), (5), (3), (1)
Pubmed 5 references available
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Product Details anti-SOS1 Antibody

Target Details SOS1 Application Details Handling References for anti-SOS1 Antibody (ABIN238504) Images
Specificity The antibody SOS-01 reacts with human Sos, an ubiquitously expressed 150 kDa intracellular protein.
Characteristics Synonyms: SOS-1, Son of sevenless homolog 1
Purification Protein A affinity chromatography.
Immunogen Peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human Sos protein.
Clone SOS-1
Isotype IgG1

Target Details SOS1

Product Details anti-SOS1 Antibody Application Details Handling References for anti-SOS1 Antibody (ABIN238504) Images back to top
Antigen
Alternative Name SOS1 (SOS1 Antibody Abstract)
Background The guanine nucleotide exchange factor Sos (Son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization, the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex.Synonyms: SOS-1, Son of sevenless homolog 1
Gene ID 6654
UniProt Q07889
Research Area Cancer
Pathways RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-SOS1 Antibody Target Details SOS1 Handling References for anti-SOS1 Antibody (ABIN238504) Images back to top
Application Notes Western Blotting under reducing conditions (1 μg/mL): Positive control: HeLa human cervix carcinoma cell line. Immunocytochemistry. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-SOS1 Antibody Target Details SOS1 Application Details References for anti-SOS1 Antibody (ABIN238504) Images back to top
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4 with 15 mM sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid freeze/thaw cycles.
Shelf life: One year from despatch.
Expiry Date 12 months

References for anti-SOS1 Antibody (ABIN238504)

Product Details anti-SOS1 Antibody Target Details SOS1 Application Details Handling Images back to top
Background publications

Freedman, Sondermann, Friedland, Kortemme, Bar-Sagi, Marqusee, Kuriyan: "A Ras-induced conformational switch in the Ras activator Son of sevenless." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 45, pp. 16692-7, 2006

Yang, Bashaw: "Son of sevenless directly links the Robo receptor to rac activation to control axon repulsion at the midline." in: Neuron, Vol. 52, Issue 4, pp. 595-607, 2006

Silver, Chen, Doyon, Zink, Rebay: "New class of Son-of-sevenless (Sos) alleles highlights the complexities of Sos function." in: Genesis (New York, N.Y. : 2000), Vol. 39, Issue 4, pp. 263-72, 2004

Innocenti, Tenca, Frittoli, Faretta, Tocchetti, Di Fiore, Scita: "Mechanisms through which Sos-1 coordinates the activation of Ras and Rac." in: The Journal of cell biology, Vol. 156, Issue 1, pp. 125-36, 2002

Tian, Feig: "Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factors." in: The Journal of biological chemistry, Vol. 276, Issue 50, pp. 47248-56, 2001

Images

Product Details anti-SOS1 Antibody Target Details SOS1 Application Details Handling References for anti-SOS1 Antibody (ABIN238504) back to top
Supplier Images
Western Blotting (WB) image for anti-SOS1 antibody (Son of Sevenless Homolog 1 (Drosophila)) (ABIN238504) anti-Son of Sevenless Homolog 1 (Drosophila) (SOS1) antibody
Immunofluorescence (IF) image for anti-SOS1 antibody (Son of Sevenless Homolog 1 (Drosophila)) (ABIN238504) anti-Son of Sevenless Homolog 1 (Drosophila) (SOS1) antibody (Image 2)
Immunofluorescence (IF) image for anti-SOS1 antibody (Son of Sevenless Homolog 1 (Drosophila)) (ABIN238504) anti-Son of Sevenless Homolog 1 (Drosophila) (SOS1) antibody (Image 3)