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|Application / Reactivity||Mouse (Murine)|
|Dot Blot (DB)||4 Antibodies|
|ELISA (Detection)||4 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies|
|Flow Cytometry (FACS)||19 Antibodies|
|Functional Studies (Func)||1 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies|
|Immunofluorescence (IF)||8 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||46 Antibodies|
|Immunohistochemistry (IHC)||12 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||4 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||15 Antibodies|
|Immunoprecipitation (IP)||6 Antibodies|
|Intracellular Staining (ICS)||4 Antibodies|
|Western Blotting (WB)||46 Antibodies|
|Antigen||TEK Tyrosine Kinase, Endothelial (TEK) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This TEK antibody is conjugated to PE Alternatives|
|4 references available|
|Supplier||Log in to see|
Product Details anti-TEK AntibodyTarget Details TEK Application Details Handling References for anti-TEK Antibody (ABIN2663161) Images
|Purification||The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.|
Target Details TEKProduct Details anti-TEK Antibody Application Details Handling References for anti-TEK Antibody (ABIN2663161) Images back to top
|Alternative Name||CD202b (TEK Antibody Abstract)|
|Background||CD202b, also known as Tie-2 or TEK, is a 145 kD type I transmembrane protein. It is a member of the receptor tyrosine kinase (RTK) family of proteins and is expressed by endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes. Angiopoietin-1 (Ang-1) is an activator of CD202b to promote, maintain, and stabilize mature vessels and to maintain HSCs in the quiescent state. Ang-2 is another ligand of CD202b, which is involved in postnatal angiogenesis and in antagonizing the effects of Ang-1. Tie-2 also binds to Ang-4.|
Application DetailsProduct Details anti-TEK Antibody Target Details TEK Handling References for anti-TEK Antibody (ABIN2663161) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-TEK Antibody Target Details TEK Application Details References for anti-TEK Antibody (ABIN2663161) Images back to top
|Buffer||Phosphate buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-TEK Antibody (ABIN2663161)Product Details anti-TEK Antibody Target Details TEK Application Details Handling Images back to top
Liu, McBride, Zhou et al.: "Regulation of endothelial progenitor cell release by Wnt signaling in bone marrow." in: Investigative ophthalmology & visual science, Vol. 54, Issue 12, pp. 7386-94, 2013 (PubMed).
Carrer, Moimas, Zacchigna et al.: "Neuropilin-1 identifies a subset of bone marrow Gr1- monocytes that can induce tumor vessel normalization and inhibit tumor growth." in: Cancer research, Vol. 72, Issue 24, pp. 6371-81, 2012 (PubMed).
Sánchez-Martín, Estecha, Samaniego et al.: "The chemokine CXCL12 regulates monocyte-macrophage differentiation and RUNX3 expression." in: Blood, Vol. 117, Issue 1, pp. 88-97, 2011 (PubMed).
Fathers, Stone, Minhas et al.: "Heterogeneity of Tie2 expression in tumor microcirculation: influence of cancer type, implantation site, and response to therapy." in: The American journal of pathology, Vol. 167, Issue 6, pp. 1753-62, 2005 (PubMed).
ImagesProduct Details anti-TEK Antibody Target Details TEK Application Details Handling References for anti-TEK Antibody (ABIN2663161) back to top