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anti-Rat (Rattus) TEK antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended TEK Antibody (supplied by: Log in to see )

Antigen
TEK Tyrosine Kinase, Endothelial (TEK) Antibodies
  • AA517024
  • CD202B
  • Cd202b
  • DKFZp469E064
  • Hyk
  • TEK
  • Tie-2
  • TIE-2
  • tie-2
  • TIE2
  • tie2
  • Tie2
  • VMCM
  • VMCM1
Epitope
AA 450-500
29
24
22
22
20
19
17
14
14
12
10
7
7
6
6
5
4
4
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
327
151
70
6
6
2
2
1
Host
Rabbit
190
142
38
3
2
2
Clonality
Polyclonal
Conjugate
This TEK antibody is un-conjugated
26
19
16
14
11
11
8
6
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
3
3
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
238
186
133
71
47
47
44
39
20
12
9
7
4
4
3
2
1
Supplier
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Catalog No. ABIN674649
$ 269.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008982679 ABIN674658 IHC (p) WB HRP Rabbit IgG AA 450-500 Log in to see Polyclonal
0.0008982679 ABIN674651 IHC (p) WB Biotin Rabbit IgG AA 450-500 Log in to see Polyclonal
0.0008982679 ABIN1700758 IHC (p) WB Biotin Rabbit IgG pTyr1102 Log in to see Polyclonal
0.0008982679 ABIN1700759 IHC (p) WB Biotin Rabbit IgG pTyr1108 Log in to see Polyclonal
0.0008982679 ABIN1711775 IHC (p) WB HRP Rabbit IgG pTyr1102 Log in to see Polyclonal
0.0008982679 ABIN1711776 IHC (p) WB HRP Rabbit IgG pTyr1108 Log in to see Polyclonal
0.0008982679 ABIN746500 IHC (p) WB Biotin Rabbit IgG pTyr992 Log in to see Polyclonal
0.0008982679 ABIN1714261 IF (p) IHC (p) WB Rabbit IgG pTyr1108 Log in to see Polyclonal
0.0008982679 ABIN1714260 IF (p) IHC (p) WB Rabbit IgG pTyr1102 Log in to see Polyclonal
0.0008982679 ABIN746507 IHC (p) WB HRP Rabbit IgG pTyr992 Log in to see Polyclonal
0.0008982679 ABIN1863207 ICC IHC (fro) IHC (p) ELISA WB Rabbit IgG Log in to see Polyclonal
0.0008982679 ABIN746483 IF (p) IHC (p) WB Rabbit IgG pSer1119 Log in to see Polyclonal
0.0008982679 ABIN746498 IF (p) IHC (p) WB Rabbit IgG pTyr992 Log in to see Polyclonal

Top referenced anti-TEK antibody for Immunohistochemistry (Paraffin-embedded Sections)

Similar anti-TEK Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
Dot Blot (DB) 4 Antibodies 4 Antibodies
ELISA 10 Antibodies 30 Antibodies
Immunocytochemistry (ICC) 1 Antibodies 14 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 45 Antibodies 45 Antibodies
Immunohistochemistry (IHC) 3 Antibodies 33 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 14 Antibodies
Immunoprecipitation (IP) 5 Antibodies
Western Blotting (WB) 26 Antibodies
ELISA (Detection) 4 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies
Flow Cytometry (FACS) 32 Antibodies
Functional Studies (Func) 1 Antibodies
Immunofluorescence (IF) 21 Antibodies

General

Antigen TEK Tyrosine Kinase, Endothelial (TEK) Antibodies
Epitope AA 450-500
(29), (24), (22), (22), (20), (19), (17), (14), (14), (12), (10), (7), (7), (6), (6), (5), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(327), (151), (70), (6), (6), (2), (2), (1)
Host Rabbit
(190), (142), (38), (3), (2), (2)
Clonality
Polyclonal
Conjugate This TEK antibody is un-conjugated
(26), (19), (16), (14), (11), (11), (8), (6), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(238), (186), (133), (71), (47), (47), (44), (39), (20), (12), (9), (7), (4), (4), (3), (2), (1)
Pubmed 1 reference available
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Product Details anti-TEK Antibody

Target Details TEK Application Details Handling References for anti-TEK Antibody (ABIN674649) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Tie2
Isotype IgG

Target Details TEK

Product Details anti-TEK Antibody Application Details Handling References for anti-TEK Antibody (ABIN674649) Images back to top
Antigen
Alternative Name Tie2/Cd202b (TEK Antibody Abstract)
Background

Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1, SHC1 and TIE1.

Subcellular location: Extracellular


Synonyms: TIE2, VMCM, TIE-2, VMCM1, CD22B, Angiopoietin-1 receptor, Endothelial tyrosine kinase, Tunica interna endothelial cell kinase, Tyrosine kinase with Ig and EGF homology domains-2, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, hTIE2, p14 TEK, TEK
Gene ID 7010
UniProt Q02763
Pathways RTK Signaling

Application Details

Product Details anti-TEK Antibody Target Details TEK Handling References for anti-TEK Antibody (ABIN674649) Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-TEK Antibody Target Details TEK Application Details References for anti-TEK Antibody (ABIN674649) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-TEK Antibody (ABIN674649)

Product Details anti-TEK Antibody Target Details TEK Application Details Handling Images back to top
Product cited in:

Zhao, Hu, Xiang, Gu, Jin, Hua, Zhang, Liu, Zan, Zhang, Zu, Yang, Shi, Zhu, Xu, Cui, Ye: "Intranasal administration of human umbilical cord mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke." in: Brain research, 2015

Images

Product Details anti-TEK Antibody Target Details TEK Application Details Handling References for anti-TEK Antibody (ABIN674649) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-TEK antibody (TEK Tyrosine Kinase, Endothelial) (AA 450-500) (ABIN674649) Formalin-fixed and paraffin embedded rat retina tissue labeled with Anti TIE2/CD202b ...