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anti-Mouse (Murine) TRKA antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended TRKA Antibody (supplied by: Log in to see )

Antigen
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies
  • C80751
  • CAPM1
  • CFTD
  • CTRKA
  • hscp30
  • MTC
  • NEM1
  • OK/SW-cl.5
  • p140-TrkA
  • Tkr
  • TM-5
  • TM3
  • TM5
  • TM30
  • TM30nm
  • TPMsk3
  • trk
  • TRK
  • Trk
  • Trk-A
  • TRK1
  • TRKA
  • TrkA
  • trkA
  • trka
Epitope
AA 480-520, pTyr496
47
24
23
19
17
16
14
13
13
13
13
12
12
12
11
10
10
9
9
8
6
6
6
6
6
5
5
4
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
377
198
168
2
2
Host
Rabbit
356
49
4
3
2
Clonality
Polyclonal
Conjugate
This TRKA antibody is un-conjugated
16
15
15
10
8
8
8
8
7
7
7
7
7
7
7
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
247
151
90
75
54
45
38
32
19
14
5
4
1
Supplier
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Catalog No. ABIN746603
$ 291.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.00087693124 ABIN726110 IF (p) IHC (p) WB Rabbit IgG AA 740-796 Log in to see Polyclonal
0.00087693124 ABIN726095 IF (p) IHC (p) WB Rabbit IgG AA 640-676 Log in to see Polyclonal
0.00087693124 ABIN746618 IF (p) IHC (p) WB Rabbit IgG pTyr674, pTyr675 Log in to see Polyclonal
0.00087693124 ABIN1399191 IF (p) Alexa Fluor 350 Rabbit IgG pTyr791 Log in to see Polyclonal
0.00087693124 ABIN1399194 IF (p) Alexa Fluor 647 Rabbit IgG pTyr791 Log in to see Polyclonal
0.00087693124 ABIN1399193 IF (p) Alexa Fluor 555 Rabbit IgG pTyr791 Log in to see Polyclonal
0.00087693124 ABIN1399196 IF (p) FITC Rabbit IgG pTyr791 Log in to see Polyclonal
0.00087693124 ABIN918687 IF (p) Alexa Fluor 555 Rabbit IgG AA 740-796 Log in to see Polyclonal
0.00087693124 ABIN918686 IF (p) Alexa Fluor 488 Rabbit IgG AA 740-796 Log in to see Polyclonal
0.00087693124 ABIN918688 IF (p) Alexa Fluor 350 Rabbit IgG AA 740-796 Log in to see Polyclonal
0.00087693124 ABIN918689 IF (p) Alexa Fluor 647 Rabbit IgG AA 740-796 Log in to see Polyclonal
0.00087693124 ABIN879813 IF (p) Alexa Fluor 555 Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal
0.00087693124 ABIN879811 IF (p) Alexa Fluor 350 Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal
0.00087693124 ABIN879814 IF (p) Alexa Fluor 488 Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal
0.00087693124 ABIN879815 IF (p) Alexa Fluor 647 Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal
0.00087693124 ABIN746607 IF (p) Cy5 Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal
0.00087693124 ABIN746606 IF (p) Cy3 Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal
0.00087693124 ABIN746608 IF (p) Cy5.5 Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal
0.00087693124 ABIN746609 IF (p) Cy7 Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal
0.00087693124 ABIN746610 IF (p) FITC Rabbit IgG AA 480-520, pTyr496 Log in to see Polyclonal

Similar anti-TRKA Antibodies

Application / Reactivity Mouse (Murine) Human
ELISA 54 Antibodies 139 Antibodies
Enzyme Immunoassay (EIA) 2 Antibodies 4 Antibodies
Flow Cytometry (FACS) 7 Antibodies 31 Antibodies
Immunochromatography (IC) 1 Antibodies 4 Antibodies
Immunocytochemistry (ICC) 5 Antibodies 12 Antibodies
Immunofluorescence (IF) 12 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 76 Antibodies
Immunohistochemistry (IHC) 38 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 29 Antibodies
Immunoprecipitation (IP) 14 Antibodies
Western Blotting (WB) 109 Antibodies
Dot Blot (DB) 19 Antibodies

General

Antigen Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies
Epitope AA 480-520, pTyr496
(47), (24), (23), (19), (17), (16), (14), (13), (13), (13), (13), (12), (12), (12), (11), (10), (10), (9), (9), (8), (6), (6), (6), (6), (6), (5), (5), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine)
(377), (198), (168), (2), (2)
Host Rabbit
(356), (49), (4), (3), (2)
Clonality
Polyclonal
Conjugate This TRKA antibody is un-conjugated
(16), (15), (15), (10), (8), (8), (8), (8), (7), (7), (7), (7), (7), (7), (7), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(247), (151), (90), (75), (54), (45), (38), (32), (19), (14), (5), (4), (1)
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Product Details anti-TRKA Antibody

Target Details TRKA Application Details Handling Images
Specificity This antibody will recognize TrkB when phosphorylated at Tyr516 and TrkC when phosphorylated at Tyr516
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human TrkA around the phosphorylation site of Tyr496
Isotype IgG

Target Details TRKA

Product Details anti-TRKA Antibody Application Details Handling Images back to top
Antigen
Alternative Name Trka (NTRK1 Antibody Abstract)
Background

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.

Subcellular location: Cytoplasm


Synonyms: High affinity nerve growth factor receptor, Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, Trk-A, gp140trk, p140-TrkA, NTRK1, MTC, TRK, TRKA
Gene ID 4914
UniProt P04629
Pathways RTK Signaling, Neurotrophin Signaling Pathway

Application Details

Product Details anti-TRKA Antibody Target Details TRKA Handling Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-TRKA Antibody Target Details TRKA Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-TRKA Antibody Target Details TRKA Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-TRKA antibody (Neurotrophic Tyrosine Kinase, Receptor, Type 1) (AA 480-520) (ABIN746603) Formalin-fixed and paraffin embedded mouse lung labeled with Rabbit Anti Phospho-TrkA...
Immunohistochemistry (IHC) image for anti-TRKA antibody (Neurotrophic Tyrosine Kinase, Receptor, Type 1) (AA 480-520) (ABIN746603) Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-Phospho-TrkA ...
SDS-PAGE (SDS) image for anti-TRKA antibody (Neurotrophic Tyrosine Kinase, Receptor, Type 1) (AA 480-520) (ABIN746603) Lane 1: mouse liver lysates Lane 2: mouse lung lysates probed with Anti Phospho-TrkA ...