anti-Rat (Rattus) TRKA antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended TRKA Antibody (supplied by: Log in to see )

Antigen
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies
  • trk
  • trka
  • TRKA
  • MTC
  • TRK
  • TRK1
  • Trk-A
  • p140-TrkA
  • C80751
  • Tkr
  • TrkA
  • Trk
  • CTRKA
  • trkA
  • CAPM1
  • CFTD
  • NEM1
  • OK/SW-cl.5
  • TM-5
  • TM3
  • TM30
  • TM30nm
  • TM5
  • TPMsk3
  • hscp30
  • neurotrophic tyrosine kinase, receptor, type 1
  • tropomyosin 3
  • ntrk1
  • NTRK1
  • LOC100354292
  • Ntrk1
  • TPM3
Epitope
AA 740-796
58
23
22
19
18
16
16
15
15
14
13
13
12
12
12
11
10
10
9
9
8
7
7
6
6
6
5
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
420
246
198
2
2
Host
Rabbit
381
64
4
4
3
Clonality
Polyclonal
Conjugate
This TRKA antibody is un-conjugated
17
15
15
11
9
9
8
8
8
8
8
7
7
7
7
7
6
2
2
2
2
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
262
148
92
87
58
57
56
43
19
10
5
5
4
3
2
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

Submit your validation data for this product and get a full refund. I want to validate this product

Learn more

Available images

Catalog No. ABIN726110
$ 307.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN703330 IF (p) IHC (p) WB Rabbit IgG pTyr817 Log in to see Polyclonal 1
1 ABIN746618 IF (p) IHC (p) WB Rabbit IgG pTyr674, pTyr675 Log in to see Polyclonal
1 ABIN726095 IF (p) IHC (p) WB Rabbit IgG AA 640-676 Log in to see Polyclonal
1 ABIN2807213 IF (p) Alexa Fluor 594 Rabbit IgG AA 740-796 Log in to see Polyclonal
1 ABIN726113 IF (p) Cy3 Rabbit IgG AA 740-796 Log in to see Polyclonal
1 ABIN726115 IF (p) Cy5.5 Rabbit IgG AA 740-796 Log in to see Polyclonal
1 ABIN726116 IF (p) Cy7 Rabbit IgG AA 740-796 Log in to see Polyclonal
1 ABIN726114 IF (p) Cy5 Rabbit IgG AA 740-796 Log in to see Polyclonal
1 ABIN726117 IF (p) FITC Rabbit IgG AA 740-796 Log in to see Polyclonal
1 ABIN918686 IF (p) Alexa Fluor 488 Rabbit IgG AA 740-796 Log in to see Polyclonal
1 ABIN918687 IF (p) Alexa Fluor 555 Rabbit IgG AA 740-796 Log in to see Polyclonal
1 ABIN918688 IF (p) Alexa Fluor 350 Rabbit IgG AA 740-796 Log in to see Polyclonal
1 ABIN918689 IF (p) Alexa Fluor 647 Rabbit IgG AA 740-796 Log in to see Polyclonal
1 ABIN2807215 IF (p) Alexa Fluor 594 Rabbit IgG AA 670-720, pTyr680, pTyr681 Log in to see Polyclonal
1 ABIN746621 IF (p) Cy3 Rabbit IgG pTyr674, pTyr675 Log in to see Polyclonal
1 ABIN746622 IF (p) Cy5 Rabbit IgG pTyr674, pTyr675 Log in to see Polyclonal
1 ABIN746623 IF (p) Cy5.5 Rabbit IgG pTyr674, pTyr675 Log in to see Polyclonal
1 ABIN746624 IF (p) Cy7 Rabbit IgG pTyr674, pTyr675 Log in to see Polyclonal
1 ABIN746625 IF (p) FITC Rabbit IgG pTyr674, pTyr675 Log in to see Polyclonal
1 ABIN880014 IF (p) Alexa Fluor 488 Rabbit IgG pTyr674, pTyr675 Log in to see Polyclonal

General

Antigen Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Antibodies
Epitope AA 740-796
(58), (23), (22), (19), (18), (16), (16), (15), (15), (14), (13), (13), (12), (12), (12), (11), (10), (10), (9), (9), (8), (7), (7), (6), (6), (6), (5), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(420), (246), (198), (2), (2)
Host Rabbit
(381), (64), (4), (4), (3)
Clonality
Polyclonal
Conjugate This TRKA antibody is un-conjugated
(17), (15), (15), (11), (9), (9), (8), (8), (8), (8), (8), (7), (7), (7), (7), (7), (6), (2), (2), (2), (2), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(262), (148), (92), (87), (58), (57), (56), (43), (19), (10), (5), (5), (4), (3), (2), (1)
Pubmed 1 reference available
Supplier Log in to see

Product Details anti-TRKA Antibody

Target Details TRKA Application Details Handling ProductDetails: References for anti-TRKA antibody (ABIN726110) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Trk A
Isotype IgG

Target Details TRKA

Product Details anti-TRKA Antibody Application Details Handling ProductDetails: References for anti-TRKA antibody (ABIN726110) Images back to top
Antigen
Alternative Name TrkA (NTRK1 Antibody Abstract)
Background

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.

Subcellular location: Cytoplasm

Synonyms: MTC, TRK, TRK1, TRKA, Trk-A, p14-TrkA, High affinity nerve growth factor receptor, Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, gp14trk, NTRK1

Gene ID 4914
UniProt P04629
Research Area Cancer
Pathways RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process

Application Details

Product Details anti-TRKA Antibody Target Details TRKA Handling ProductDetails: References for anti-TRKA antibody (ABIN726110) Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-TRKA Antibody Target Details TRKA Application Details ProductDetails: References for anti-TRKA antibody (ABIN726110) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

ProductDetails: References for anti-TRKA antibody (ABIN726110)

Product Details anti-TRKA Antibody Target Details TRKA Application Details Handling Images back to top
Product cited in:

Li, Shen, Di, Li, Geng, Lu, He: "Biological and clinical significance of p75NTR expression in laryngeal squamous epithelia and laryngocarcinoma." in: Acta oto-laryngologica, Vol. 132, Issue 3, pp. 314-24, 2012

Images

Product Details anti-TRKA Antibody Target Details TRKA Application Details Handling ProductDetails: References for anti-TRKA antibody (ABIN726110) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 740-796) antibody (ABIN726110) Formalin-fixed and paraffin embedded: human endometrium Anti-TrK-A/NTRK1 Polyclonal A...