anti-Human TRKB antibody for Flow Cytometry

Recommended TRKB Antibody (supplied by: Log in to see )

Antigen
Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) Antibodies
  • trkb
  • trkb-b
  • xtrkb
  • si:ch211-220b11.1
  • trkB2
  • NTRK2
  • ntrk2
  • gp145-trkb
  • TRKB
  • GP145-TrkB
  • trk-B
  • AI848316
  • C030027L06Rik
  • Tkrb
  • trkB
  • RATTRKB1
  • TRKB1
  • Trk-B
  • TrkB
  • neurotrophic tyrosine kinase, receptor, type 2
  • neurotrophic tyrosine kinase, receptor, type 2b
  • NTRK2
  • ntrk2-b
  • ntrk2b
  • ntrk2-a
  • ntrk2
  • Ntrk2
Epitope
AA 370-429
26
26
18
16
15
15
14
14
14
13
10
9
9
9
8
8
6
6
6
5
5
4
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
319
195
179
14
13
10
8
8
4
2
1
1
1
1
Host
Rabbit
252
82
15
6
4
1
Clonality
Polyclonal
Conjugate
This TRKB antibody is un-conjugated
7
7
7
7
6
6
4
4
4
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
246
139
128
71
50
45
26
12
9
5
4
4
2
2
1
1
1
1
1
1
Options
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Catalog No. ABIN725870
$ 307.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
14.213261 ABIN1995535 FACS PE Mouse IgG1 AA 1-430 Log in to see 12
14.213261 ABIN1995533 CC ELISA FACS Mouse IgG1 AA 1-430, Extracellular Domain Log in to see 7H6E7B3
14.213261 ABIN5503037 FACS Alexa Fluor 405 Mouse IgG1 AA 32-430 Log in to see 72509
1 ABIN4900869 CyTOF FACS SimWes WB Goat IgG Log in to see Polyclonal 1
1 ABIN4900211 CyTOF FACS Mouse IgG1 AA 32-430 Log in to see 72509 3
1 ABIN4900212 CyTOF FACS Mouse IgG1 AA 32-430 Log in to see 72509 3
1 ABIN725877 FACS IF (p) FITC Rabbit IgG AA 370-429 Log in to see Polyclonal
1 ABIN725874 FACS IF (p) Cy5 Rabbit IgG AA 370-429 Log in to see Polyclonal
1 ABIN725873 FACS IF (p) Cy3 Rabbit IgG AA 370-429 Log in to see Polyclonal
1 ABIN725875 FACS IF (p) Cy5.5 Rabbit IgG AA 370-429 Log in to see Polyclonal
1 ABIN725876 FACS IF (p) Cy7 Rabbit IgG AA 370-429 Log in to see Polyclonal
1 ABIN918698 FACS IF (p) Alexa Fluor 350 Rabbit IgG AA 370-429 Log in to see Polyclonal
1 ABIN918694 FACS IF (p) Alexa Fluor 647 Rabbit IgG AA 370-429 Log in to see Polyclonal
1 ABIN918693 FACS IF (p) Alexa Fluor 555 Rabbit IgG AA 370-429 Log in to see Polyclonal
1 ABIN918696 FACS IF (p) Alexa Fluor 488 Rabbit IgG AA 370-429 Log in to see Polyclonal
1 ABIN2809018 FACS IF (p) Alexa Fluor 594 Rabbit IgG AA 370-429 Log in to see Polyclonal
1 ABIN4362579 FACS Alexa Fluor 488 Mouse IgG1 AA 32-430 Log in to see 72509
1 ABIN4362580 FACS Alexa Fluor 700 Mouse IgG1 AA 32-430 Log in to see 72509
1 ABIN4362581 FACS Alexa Fluor 647 Mouse IgG1 AA 32-430 Log in to see 72509
1 ABIN4362583 FACS Alexa Fluor 594 Mouse IgG1 AA 32-430 Log in to see 72509

General

Antigen Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) Antibodies
Epitope AA 370-429
(26), (26), (18), (16), (15), (15), (14), (14), (14), (13), (10), (9), (9), (9), (8), (8), (6), (6), (6), (5), (5), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(319), (195), (179), (14), (13), (10), (8), (8), (4), (2), (1), (1), (1), (1)
Host Rabbit
(252), (82), (15), (6), (4), (1)
Clonality
Polyclonal
Conjugate This TRKB antibody is un-conjugated
(7), (7), (7), (7), (6), (6), (4), (4), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(246), (139), (128), (71), (50), (45), (26), (12), (9), (5), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-TRKB Antibody

Target Details TRKB Application Details Handling ProductDetails: References for anti-TRKB antibody (ABIN725870) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from rat TrkB
Isotype IgG

Target Details TRKB

Product Details anti-TRKB Antibody Application Details Handling ProductDetails: References for anti-TRKB antibody (ABIN725870) Images back to top
Antigen
Alternative Name TrkB (NTRK2 Antibody Abstract)
Background

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.

Subcellular location: Extracellular

Synonyms: TRKB, trk-B, GP145-TrkB, BDNF/NT-3 growth factors receptor, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B, NTRK2

Gene ID 4915
UniProt Q16620
Research Area Cancer
Pathways RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport

Application Details

Product Details anti-TRKB Antibody Target Details TRKB Handling ProductDetails: References for anti-TRKB antibody (ABIN725870) Images back to top
Application Notes WB 1:100-1000
FCM 1:20-100
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-TRKB Antibody Target Details TRKB Application Details ProductDetails: References for anti-TRKB antibody (ABIN725870) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

ProductDetails: References for anti-TRKB antibody (ABIN725870)

Product Details anti-TRKB Antibody Target Details TRKB Application Details Handling Images back to top
Product cited in:

Zhu, Xia, Han, Shao, Jing, Fan, Liu, Diao, Lv, Sun: "Xiao Yao San Improves Depressive-Like Behavior in Rats through Modulation of ?-Arrestin 2-Mediated Pathways in Hippocampus." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2014, pp. 902516, 2014

Images

Product Details anti-TRKB Antibody Target Details TRKB Application Details Handling ProductDetails: References for anti-TRKB antibody (ABIN725870) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (AA 370-429) antibody (ABIN725870) Formalin-fixed and paraffin embedded: human nasopharyngeal carcinoma labeled with Ant...
SDS-PAGE (SDS) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (AA 370-429) antibody (ABIN725870) L1 rat brain lysates L2 rat kidney lysates probed with Anti Trk B/NTRK2 Polyclonal An...
Flow Cytometry (FACS) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) (AA 370-429) antibody (ABIN725870) RSC96 cells probed with TrkB Polyclonal Antibody, Unconjugated at [CNC.] for 30 minu...