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|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)|
|Western Blotting (WB)||158 Antibodies||102 Antibodies||97 Antibodies|
|Proximity Ligation Assay (PLA)||1 Antibodies|
|Immunoprecipitation (IP)||5 Antibodies||3 Antibodies||5 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||25 Antibodies||19 Antibodies||19 Antibodies|
|Immunohistochemistry (IHC)||66 Antibodies||75 Antibodies||86 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||23 Antibodies||23 Antibodies||23 Antibodies|
|Immunofluorescence (IF)||39 Antibodies|
|Antigen||Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This TRKB antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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Product Details anti-TRKB AntibodyTarget Details TRKB Application Details Handling Images
|Specificity||This antibody detects endogenous levels of Trk B protein. (region surrounding Asp699)|
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
|Purity||> 95 % by SDS-PAGE|
Target Details TRKBProduct Details anti-TRKB Antibody Application Details Handling Images back to top
|Alternative Name||TrkB (NTRK2 Antibody Abstract)|
|Background||The Trk proto-oncogene encodes a tyrosine protein kinase, Trk A, also designated Trk gp140, that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3). Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3. The third member of the Trk family of tyrosine kinases, Trk C, encodes a protein designated Trk C gp145 that is preferentially expressed in brain tissue, is equally related to Trk A and Trk B, and is a functional receptor for NT-3.Synonyms: BDNF/NT-3 growth factors receptor, GP145-TrkB, NTRK2, Neurotrophic tyrosine kinase receptor type 2, TRKB, TrkB tyrosine kinase|
|Molecular Weight||approx. 92, 145 kDa|
|Pathways||RTK Signaling, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-TRKB Antibody Target Details TRKB Handling Images back to top
Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TRKB Antibody Target Details TRKB Application Details Images back to top
|Buffer||Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
ImagesProduct Details anti-TRKB Antibody Target Details TRKB Application Details Handling back to top