anti-Mouse (Murine) TRKB antibody for Immunoprecipitation

Recommended TRKB Antibody (supplied by: Log in to see )

Antigen
Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) Antibodies
  • trkb
  • trkb-b
  • xtrkb
  • si:ch211-220b11.1
  • trkB2
  • NTRK2
  • ntrk2
  • gp145-trkb
  • TRKB
  • GP145-TrkB
  • trk-B
  • AI848316
  • C030027L06Rik
  • Tkrb
  • trkB
  • RATTRKB1
  • TRKB1
  • Trk-B
  • TrkB
  • neurotrophic tyrosine kinase, receptor, type 2
  • neurotrophic tyrosine kinase, receptor, type 2b
  • NTRK2
  • ntrk2-b
  • ntrk2b
  • ntrk2-a
  • ntrk2
  • Ntrk2
Reactivity
Chicken, Human, Mouse (Murine), Rat (Rattus)
329
195
179
13
13
10
8
8
4
2
1
1
1
1
Host
Rabbit
252
91
16
6
4
1
Clonality
Polyclonal
Conjugate
This TRKB antibody is un-conjugated
7
7
7
7
7
7
5
5
5
5
5
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
247
139
128
82
51
44
27
12
8
7
5
4
2
2
2
1
1
1
1
1
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Catalog No. ABIN223287
$ 295.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1585457 IP IHC ELISA WB Rabbit N-Term Log in to see Polyclonal
1 ABIN4965710 IF IP WB Rabbit IgG Log in to see Polyclonal
1 ABIN1003382 IF IP WB Rabbit IgG Log in to see Polyclonal

General

Antigen Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) Antibodies
Reactivity Chicken, Human, Mouse (Murine), Rat (Rattus)
(329), (195), (179), (13), (13), (10), (8), (8), (4), (2), (1), (1), (1), (1)
Host Rabbit
(252), (91), (16), (6), (4), (1)
Clonality
Polyclonal
Conjugate This TRKB antibody is un-conjugated
(7), (7), (7), (7), (7), (7), (5), (5), (5), (5), (5), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(247), (139), (128), (82), (51), (44), (27), (12), (8), (7), (5), (4), (2), (2), (2), (1), (1), (1), (1), (1)
Pubmed 4 references available
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Product Details anti-TRKB Antibody

Target Details TRKB Application Details Handling References for anti-TRKB antibody (ABIN223287) Images
Blocking Peptide Blocking peptide for this product available: ABIN412957
Specificity Trk protein exists as variably glycosylated entities with the major forms having molecular weights of 140 kDa, 110 kDa, and the unglycosylated form of 80 kDa. .
Purification Affinity purified
Immunogen Synthetic peptide surrounding amino acid 810 of human TrkB
Isotype IgG

Target Details TRKB

Product Details anti-TRKB Antibody Application Details Handling References for anti-TRKB antibody (ABIN223287) Images back to top
Antigen
Alternative Name TrkB (NTRK2 Antibody Abstract)
Background Due to the various splice variants, the trk proteins exist as variably glycosylated entities with the major forms having molecular weights of 140-145 kDa, 110 kDa and the unglycosylated form of 80 kDa. trkB contains 33.3 % carbohydrate by weight representing modification on 10 of 12 N-glycosylation sites. The primary ligand for trkB is BDNF which induces the phosphorylation of the protein and subsequent binding of PLC-gamma via SH2 domains. TrkB may function to modulate neuronal responses to the neurotrophins acting throμgh trkB such as BDNF.
Synonyms: NTRK2 , GP145-TrkB , TRKB , Trk-B , tyrosine receptor kinase
Gene ID 25054
UniProt Q63604
Research Area Cancer
Pathways RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport

Application Details

Product Details anti-TRKB Antibody Target Details TRKB Handling References for anti-TRKB antibody (ABIN223287) Images back to top
Application Notes Western blotting (0.5-4 μg/mL), immunofluorescence (5-10 μg/mL). However, the optimal concentrations should be determined individually. Trk protein exists as variably glycosylated entities with the major forms having molecular weights of 140 kDa, 110 kDa, and the unglycosylated form of 80 kDa.
Restrictions For Research Use only

Handling

Product Details anti-TRKB Antibody Target Details TRKB Application Details References for anti-TRKB antibody (ABIN223287) Images back to top
Format Liquid
Concentration 0.5 mg/mL
Buffer 100 μg (0.2 mg/mL) immunoaffinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months

References for anti-TRKB antibody (ABIN223287)

Product Details anti-TRKB Antibody Target Details TRKB Application Details Handling Images back to top
Product cited in:

Shen, Ghai, Sompol, Liu, Cao, Iuvone, Ye: "N-acetyl serotonin derivatives as potent neuroprotectants for retinas." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 9, pp. 3540-5, 2012

Jang, Liu, Pradoldej, Tosini, Chang, Iuvone, Ye: "N-acetylserotonin activates TrkB receptor in a circadian rhythm." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 8, pp. 3876-81, 2010

Jang, Liu, Chan, France, Sayeed, Tang, Lin, Xiao, Andero, Chang, Ressler, Ye: "Deoxygedunin, a natural product with potent neurotrophic activity in mice." in: PLoS ONE, Vol. 5, Issue 7, pp. e11528, 2010

Jang, Liu, Yepes, Shepherd, Miller, Liu, Wilson, Xiao, Blanchi, Sun, Ye: "A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 6, pp. 2687-92, 2010

Images

Product Details anti-TRKB Antibody Target Details TRKB Application Details Handling References for anti-TRKB antibody (ABIN223287) back to top
Supplier Images
Western Blotting (WB) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) antibody (ABIN223287) Western Blot Analysis of trkB expression in HL-60 Cell Lysate.