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anti-Rat (Rattus) TRKB antibody for BioImaging

Recommended TRKB Antibody (supplied by: Log in to see )

Antigen
Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) Antibodies
  • AI848316
  • C030027L06Rik
  • gp145-trkb
  • GP145-TrkB
  • NTRK2
  • ntrk2
  • RATTRKB1
  • si:ch211-220b11.1
  • Tkrb
  • Trk-B
  • trk-B
  • TRKB
  • trkb
  • trkB
  • TrkB
  • trkb-b
  • TRKB1
  • trkB2
  • xtrkb
Epitope
AA 156-322
26
23
20
16
16
15
13
13
12
11
10
7
7
7
6
6
6
5
5
5
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Rat (Rattus)
279
148
142
9
6
4
4
4
2
1
Host
Mouse
230
66
12
5
3
Clonality
Monoclonal
Conjugate
This TRKB antibody is un-conjugated
7
7
7
6
5
5
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
BioImaging (BI), Fluorescence Microscopy (FM), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
228
128
107
49
39
29
23
10
6
3
1
1
1
1
Supplier
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Catalog No. ABIN967745
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008711731 ABIN967746 BI FM IP IHC WB Mouse IgG1 AA 156-322 Log in to see 47-TrkB 7

Top referenced anti-TRKB antibody for BioImaging

Similar anti-TRKB Antibodies

Application / Reactivity Rat (Rattus)
BioImaging (BI) 2 Antibodies
ELISA 33 Antibodies
Fluorescence Microscopy (FM) 2 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunocytochemistry (ICC) 7 Antibodies
Immunofluorescence (IF) 23 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 23 Antibodies
Immunohistochemistry (IHC) 70 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 23 Antibodies
Immunoprecipitation (IP) 5 Antibodies
Western Blotting (WB) 102 Antibodies

General

Antigen Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) Antibodies
Epitope AA 156-322
(26), (23), (20), (16), (16), (15), (13), (13), (12), (11), (10), (7), (7), (7), (6), (6), (6), (5), (5), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Rat (Rattus)
(279), (148), (142), (9), (6), (4), (4), (4), (2), (1)
Host Mouse
(230), (66), (12), (5), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TRKB antibody is un-conjugated
(7), (7), (7), (6), (5), (5), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application BioImaging (BI), Fluorescence Microscopy (FM), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(228), (128), (107), (49), (39), (29), (23), (10), (6), (3), (1), (1), (1), (1)
Pubmed 7 references available
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Product Details anti-TRKB Antibody

Target Details TRKB Application Details Handling References for anti-TRKB Antibody (ABIN967745) Images
Cross-Reactivity Rat (Rattus), Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Human TrkB aa. 156-322
Clone 47-TrkB
Isotype IgG1

Target Details TRKB

Product Details anti-TRKB Antibody Application Details Handling References for anti-TRKB Antibody (ABIN967745) Images back to top
Antigen
Alternative Name TrkB (NTRK2 Antibody Abstract)
Background The full-length TrkB gene has been reported to encode for a 145 kDa glycosylated transmembrane tyrosine kinase and neurotrophin receptor. The same gene also has been reported to encode for a 95 kDa glycoprotein that is identical to gp145 [TrkB] at the extracellular domain and transmembrane portion but lacks the intracellular portion. TrkB has been observable in a range of 116-145 kD and 70-95 kD due to various TrkB maturation states, subcellular localizations, and glycosylation states. TrkB belongs to a family of tyrosine kinases that include the TrkA proto-oncogene and TrkC. All have an extracellular ligand-binding domain, a transmembrane region, and intracellular kinase and autophosphorylation domains. TrkB binds the neurotrophins NT3 and NT4/5, as well as brain-derived neurotrophic factor (BDNF), a peptide that helps motor neuron survival and repair. The TrkB tyrosine kinase is activated upon binding to BDNF resulting in autophosphorylation of residues Y670, Y674 and Y675 and the subsequent association of several intracellular proteins like PLCgamma, Shc, and PI3-Kinase. TrkB is widely expressed in cells of neuroepithelium and neural crest origin. Some of these include motor neurons, dopamine-producing neurons, and neurons which release gamma-aminobutyric acid in the substantia nigra, neocortex, and hippocampus. The two TrkB gene products are differentially expressed in regions of the adult brain.
Synonyms: Neurotrophic Tyrosine Kinase Receptor Type 2, NTRK2
Molecular Weight 116-145 & 70-95 kDa
Research Area Cancer
Pathways RTK Signaling, Neurotrophin Signaling Pathway

Application Details

Product Details anti-TRKB Antibody Target Details TRKB Handling References for anti-TRKB Antibody (ABIN967745) Images back to top
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only

Handling

Product Details anti-TRKB Antibody Target Details TRKB Application Details References for anti-TRKB Antibody (ABIN967745) Images back to top
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.

References for anti-TRKB Antibody (ABIN967745)

Product Details anti-TRKB Antibody Target Details TRKB Application Details Handling Images back to top
Product cited in:

Du, Feng, Yang, Lu: "Activity- and Ca(2+)-dependent modulation of surface expression of brain-derived neurotrophic factor receptors in hippocampal neurons." in: The Journal of cell biology, Vol. 150, Issue 6, pp. 1423-34, 2000

Muller, Djebbara-Hannas, Jourdain, Vutskits, Durbec, Rougon, Kiss: "Brain-derived neurotrophic factor restores long-term potentiation in polysialic acid-neural cell adhesion molecule-deficient hippocampus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 8, pp. 4315-20, 2000

Jovanovic, Czernik, Fienberg, Greengard, Sihra: "Synapsins as mediators of BDNF-enhanced neurotransmitter release." in: Nature neuroscience, Vol. 3, Issue 4, pp. 323-9, 2000

Kryl, Yacoubian, Haapasalo, Castren, Lo, Barker: "Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 14, pp. 5823-33, 1999

Armanini, McMahon, Sutherland, Shelton, Phillips: "Truncated and catalytic isoforms of trkB are co-expressed in neurons of rat and mouse CNS." in: The European journal of neuroscience, Vol. 7, Issue 6, pp. 1403-9, 1995

Ebendal: "Function and evolution in the NGF family and its receptors." in: Journal of neuroscience research, Vol. 32, Issue 4, pp. 461-70, 1992

Background publications

Klein, Conway, Parada, Barbacid: "The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain." in: Cell, Vol. 61, Issue 4, pp. 647-56, 1990

Images

Product Details anti-TRKB Antibody Target Details TRKB Application Details Handling References for anti-TRKB Antibody (ABIN967745) back to top
Supplier Images
Western Blotting (WB) image for anti-TRKB antibody (Neurotrophic Tyrosine Kinase, Receptor, Type 2) (AA 156-322) (ABIN967745) Western blot analysis of TrkB on a rat cerebrum lysate (left). Lane 1: 1:250, lane 2:...
Immunofluorescence (IF) image for anti-TRKB antibody (Neurotrophic Tyrosine Kinase, Receptor, Type 2) (AA 156-322) (ABIN967745) Immunofluorescent staining of undifferentiated (left) and differentiated (right) SH-S...
Immunofluorescence (IF) image for anti-TRKB antibody (Neurotrophic Tyrosine Kinase, Receptor, Type 2) (AA 156-322) (ABIN967745) Immunofluorescent staining of differentiated SH-SY5Y cells