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Browse our anti-TSC1 (TSC1) Antibodies

Full name:
anti-Tuberous Sclerosis 1 Antibodies (TSC1)
On www.antibodies-online.com are 784 Tuberous Sclerosis 1 (TSC1) Antibodies from 26 different suppliers available. Additionally we are shipping TSC1 Proteins (3) and TSC1 Kits (2) and many more products for this protein. A total of 806 TSC1 products are currently listed.
Synonyms:
hamartin, LAM, mKIAA0243, TSC, tsc1, wu:fc38b04

Most Popular Reactivities for anti-TSC1 (TSC1) Antibodies

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anti-Human TSC1 Antibodies:

anti-Mouse (Murine) TSC1 Antibodies:

anti-Rat (Rattus) TSC1 Antibodies:

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Top referenced anti-TSC1 Antibodies

  1. Human Polyclonal TSC1 Primary Antibody for DB - ABIN1881927 : Hoogeveen-Westerveld, Exalto, Maat-Kievit, van den Ouweland, Halley, Nellist: Analysis of TSC1 truncations defines regions involved in TSC1 stability, aggregation and interaction. in Biochimica et biophysica acta 2010 (PubMed)
    Show all 5 references for ABIN1881927

  2. Human Polyclonal TSC1 Primary Antibody for DB - ABIN1881929 : Mehta, Vazquez, Kulkarni, Kerrigan, Atwal, Metsugi, Toppmeyer, Levine, Hirshfield: Polymorphic variants in TSC1 and TSC2 and their association with breast cancer phenotypes. in Breast cancer research and treatment 2011 (PubMed)
    Show all 5 references for ABIN1881929

  3. Human Polyclonal TSC1 Primary Antibody for EIA - ABIN358402 : Wu, Khalil, Keehn, Saeed, Morgan: Hamartin and tuberin immunohistochemical expression in cutaneous fibroepithelial polyps. in Journal of cutaneous pathology 2004 (PubMed)
    Show all 5 references for ABIN358402

  4. Human Polyclonal TSC1 Primary Antibody for EIA, IF - ABIN501071 : Shamji, Nghiem, Schreiber: Integration of growth factor and nutrient signaling: implications for cancer biology. in Molecular cell 2003 (PubMed)
    Show all 4 references for ABIN501071

  5. Human Polyclonal TSC1 Primary Antibody for IHC, ELISA - ABIN185619 : Chan, Zhang, Roberts, Jozwiak, Wieslawa, Lewin-Kowalik, Kotulska, Kwiatkowski: Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. in Journal of neuropathology and experimental neurology 2004 (PubMed)
    Show all 3 references for ABIN185619

  6. Mouse (Murine) Polyclonal TSC1 Primary Antibody for DB - ABIN1881916 : Akpa, Oyejola: Modeling the transmission dynamics of HIV/AIDS epidemics: an introduction and a review. in Journal of infection in developing countries 2010 (PubMed)
    Show all 2 references for ABIN1881916

  7. Mouse (Murine) Polyclonal TSC1 Primary Antibody for DB - ABIN1881914 : Kladney, Cardiff, Kwiatkowski, Chiang, Weber, Arbeit, Lu: Tuberous sclerosis complex 1: an epithelial tumor suppressor essential to prevent spontaneous prostate cancer in aged mice. in Cancer research 2010 (PubMed)
    Show all 2 references for ABIN1881914

  8. Human Polyclonal TSC1 Primary Antibody for IF, IHC (p) - ABIN652207 : Lewis, Thomas, Murphy, Sampson: Genotype and psychological phenotype in tuberous sclerosis. in Journal of medical genetics 2004 (PubMed)
    Show all 2 references for ABIN652207

More Antibodies against TSC1 Interaction Partners

Zebrafish Tuberous Sclerosis 1 (TSC1) interaction partners

  1. Tsc1 is involved in regulation of interactive network between the cilium and the TOR pathway.

Human Tuberous Sclerosis 1 (TSC1) interaction partners

  1. Each TBC1D7 (show TBC1D7 Antibodies) molecule interacts simultaneously with two parallel TSC1 helices from two TSC1 molecules, suggesting that TBC1D7 (show TBC1D7 Antibodies) may stabilize the TSC (show SLC12A3 Antibodies) complex by tethering the C-terminal ends of two TSC1 coiled-coils.

  2. IQ/DQ correlates inversely with predicted levels and/or deleterious biochemical effects of mutant TSC1 or TSC2 (show TSC2 Antibodies) protein in tuberous sclerosis complex.

  3. AKT3 (show AKT3 Antibodies) has a role in prostate cancer proliferation through regulation of Akt (show AKT1 Antibodies), B-Raf (show SNRPE Antibodies), and TSC1/TSC2 (show TSC2 Antibodies)

  4. Tsc1 transgenic mice exhibit an age-dependent seizure pattern sequence mimicking early human tuberous sclerosis complex epilepsy.

  5. PAK2 (show PAK2 Antibodies) is a direct effector of TSC1-TSC2 (show TSC2 Antibodies)-RHEB (show RHEB Antibodies) signaling and a new target for rational drug therapy in TSC (show SLC12A3 Antibodies).

  6. These findings indicate that Tsc1 prevents aberrant renal growth and tumorigenesis by inhibiting mTORC1 signaling, whereas phosphorylated rpS6 (show RPS6 Antibodies) suppresses cystogenesis and fibrosis in Tsc1-deleted kidneys

  7. Data show that 10 pathogenic mutations were quickly identified, 7 were located in tuberous sclerosis 1 protein (TSC1) and 3 were observed in tuberous sclerosis 2 protein (TSC2 (show TSC2 Antibodies)).

  8. Tuberous sclerosis is a syndrome caused by dominant mutations in Hamartin (TSC1),causing Autism spectrum disorder - like behaviors, seizures, intellectual disability and characteristic brain and skin lesions.

  9. TSC1 and TSC2 (show TSC2 Antibodies) mutations are associated with tuberous sclerosis.

  10. TSC (show SLC12A3 Antibodies)-related tumors can increase the mutation detection rate, indicate that it is not likely that a third TSC (show SLC12A3 Antibodies) gene exists, and enable provision of genetic counseling to the substantial population of TSC (show SLC12A3 Antibodies) individuals who are currently NMI (show MYO1C Antibodies)

Mouse (Murine) Tuberous Sclerosis 1 (TSC1) interaction partners

  1. TSC1 knockout mice are lean, glucose intolerant with a decreased activation of protein kinase B (Akt/PKB (show AKT1 Antibodies)) targets that regulate glucose transporters in skeletal muscle.

  2. a pivotal role for Tsc1 in regulating various aspects of visual-pathway development, is reported.

  3. PAK2 (show PAK2 Antibodies) is a direct effector of TSC1-TSC2 (show TSC2 Antibodies)-RHEB (show RHEB Antibodies) signaling and a new target for rational drug therapy in TSC (show SLC12A3 Antibodies).

  4. Tsc1 plays a critical role in regulating macrophage survival, function and polarization via inhibition of mTORC1 activity.

  5. TSC1-KO results in the accumulation of transitional-1 B cells and progressive losses of B cells as they mature beyond the T1 stage. However, Peyer's patch germinal centers are unimpaired in TSC1-KO mice.

  6. TSC1 deletion led to enhanced mTORC1 signaling in neural crest derived bones and the increase in bone formation is responsible for the aberrantly increased bone mass.

  7. Results describe the development of new vascular mouse model with a conditional knockout allele of Tsc1 with a Darpp32 (show PPP1R1B Antibodies)-Cre allele. This mouse displayed accelerated formation of both kidney cystadenomas and paw hemangiosarcomas.

  8. PLK1 (show PLK1 Antibodies) protein levels are increased in hamartin and tuberin (show TSC2 Antibodies) deficient cells and Lymphangioleiomyomatosis patient-derived specimens, and that this increase is rapamycin-sensitive.

  9. Tuberless heterozygote Tsc1+/- mice show functional up-regulation of cortical GluN2C (show GRIN2C Antibodies) receptors in an mTOR (show FRAP1 Antibodies)-dependent manner, exhibit recurrent, unprovoked seizures during early postnatal life, that can be treated with GluN2C (show GRIN2C Antibodies) antagonists.

  10. The findings define a key role for TSC1 in orchestrating macrophage polarization via mTOR (show FRAP1 Antibodies)-dependent and independent pathways.

TSC1 Antigen Profile

Antigen Summary

This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with TSC1

  • tuberous sclerosis 1 (TSC1) antibody
  • tuberous sclerosis 1b (tsc1b) antibody
  • tuberous sclerosis 1 (tsc1) antibody
  • tuberous sclerosis 1 (Tsc1) antibody
  • hamartin antibody
  • LAM antibody
  • mKIAA0243 antibody
  • TSC antibody
  • tsc1 antibody
  • wu:fc38b04 antibody

Protein level used designations for TSC1

tuberous sclerosis 1 protein , tuberous sclerosis 1 , fc38b04 , hamartin , hamartin-like , tumor suppressor , tuberous sclerosis 1 protein homolog , chromosome 9 TSC1

GENE ID SPECIES
100066615 Equus caballus
464818 Pan troglodytes
100017591 Monodelphis domestica
100080641 Ornithorhynchus anatinus
100330617 Danio rerio
100338695 Oryctolagus cuniculus
100380126 Xenopus (Silurana) tropicalis
100407741 Callithrix jacchus
100471530 Ailuropoda melanoleuca
100539473 Meleagris gallopavo
100587112 Nomascus leucogenys
7248 Homo sapiens
64930 Mus musculus
60445 Rattus norvegicus
480688 Canis lupus familiaris
100154726 Sus scrofa
533440 Bos taurus
417166 Gallus gallus
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