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anti-Human TSC1 antibody for Enzyme Immunoassay

Recommended TSC1 Antibody (supplied by: Log in to see )

Antigen
Tuberous Sclerosis 1 (TSC1) Antibodies
  • hamartin
  • LAM
  • mKIAA0243
  • TSC
  • tsc1
  • wu:fc38b04
Epitope
pSer505
52
40
40
40
40
26
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
17
15
12
12
12
12
10
8
7
7
7
7
7
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
4
4
4
3
3
3
2
2
1
1
1
1
Reactivity
Human
436
363
155
5
1
1
1
1
1
1
Host
Rabbit
731
45
18
1
Clonality
Polyclonal
Conjugate
This TSC1 antibody is un-conjugated
67
67
67
64
64
64
4
4
4
4
3
3
3
3
3
1
1
1
Application
Enzyme Immunoassay (EIA)
532
491
158
64
33
33
20
16
12
8
3
2
1
Supplier
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Catalog No. ABIN358402
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008867729 ABIN501071 EIA IF WB Rabbit IgG Middle Region, both Isoforms Log in to see Polyclonal 4
0.0008867729 ABIN501069 EIA WB Rabbit IgG C-Term Log in to see Polyclonal 4
0.0008867729 ABIN2734416 EIA WB Rabbit IgG Log in to see Polyclonal

Top referenced anti-TSC1 antibody for Enzyme Immunoassay

Similar anti-TSC1 Antibodies

Application / Reactivity Human
Dot Blot (DB) 209 Antibodies
ELISA 248 Antibodies
Enzyme Immunoassay (EIA) 4 Antibodies
Flow Cytometry (FACS) 11 Antibodies
Immunochromatography (IC) 2 Antibodies
Immunocytochemistry (ICC) 16 Antibodies
Immunofluorescence (IF) 20 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 33 Antibodies
Immunohistochemistry (IHC) 65 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 34 Antibodies
Immunoprecipitation (IP) 8 Antibodies
Western Blotting (WB) 143 Antibodies

General

Antigen Tuberous Sclerosis 1 (TSC1) Antibodies
Epitope pSer505
(52), (40), (40), (40), (40), (26), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (17), (15), (12), (12), (12), (12), (10), (8), (7), (7), (7), (7), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (4), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1)
Reactivity Human
(436), (363), (155), (5), (1), (1), (1), (1), (1), (1)
Host Rabbit
(731), (45), (18), (1)
Clonality
Polyclonal
Conjugate This TSC1 antibody is un-conjugated
(67), (67), (67), (64), (64), (64), (4), (4), (4), (4), (3), (3), (3), (3), (3), (1), (1), (1)
Application Enzyme Immunoassay (EIA)
(532), (491), (158), (64), (33), (33), (20), (16), (12), (8), (3), (2), (1)
Pubmed 5 references available
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Product Details anti-TSC1 Antibody

Target Details TSC1 Application Details Handling References for anti-TSC1 Antibody (ABIN358402) Images
Specificity This antibody detects TSC1 pSer505.
Purification Affinity purification in a 2-step procedure with the control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S505 of human TSC1.
Isotype Ig

Target Details TSC1

Product Details anti-TSC1 Antibody Application Details Handling References for anti-TSC1 Antibody (ABIN358402) Images back to top
Antigen
Alternative Name TSC1 / Hamartin (TSC1 Antibody Abstract)
Background TSC1 is implicated as a tumor suppressor, and may have a function in vesicular transport. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Defects in TSC1 are the cause of tuberous sclerosis complex (TSC). The molecular basis of TSC is a functional impairement of the hamartin-tuberin complex. TSC is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC). FCDBC is a subtype of cortical displasias linked to chronic intractable epilepsy. Cortical dysplasias display a broad spectrum of structural changes, which appear to result from changes in proliferation, migration, differentiation, and apoptosis of neuronal precursors and neurons during cortical development.Synonyms: KIAA0243, TSC, Tuberous sclerosis 1 protein
Molecular Weight 129767 Da
Gene ID 7248, 9606
UniProt Q92574
Pathways RTK Signaling, AMPK Signaling

Application Details

Product Details anti-TSC1 Antibody Target Details TSC1 Handling References for anti-TSC1 Antibody (ABIN358402) Images back to top
Application Notes ELISA: 1/1,000. Dot Blot: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-TSC1 Antibody Target Details TSC1 Application Details References for anti-TSC1 Antibody (ABIN358402) Images back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References for anti-TSC1 Antibody (ABIN358402)

Product Details anti-TSC1 Antibody Target Details TSC1 Application Details Handling Images back to top
Background publications

Wu, Khalil, Keehn, Saeed, Morgan: "Hamartin and tuberin immunohistochemical expression in cutaneous fibroepithelial polyps." in: Journal of cutaneous pathology, Vol. 31, Issue 5, pp. 383-7, 2004

Jó?wiak, Kwiatkowski, Kotulska, Larysz-Brysz, Lewin-Kowalik, Grajkowska, Roszkowski: "Tuberin and hamartin expression is reduced in the majority of subependymal giant cell astrocytomas in tuberous sclerosis complex consistent with a two-hit model of pathogenesis." in: Journal of child neurology, Vol. 19, Issue 2, pp. 102-6, 2004

Murthy, Han, Beauchamp, Smith, Haddad, Ito, Ramesh: "Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex." in: The Journal of biological chemistry, Vol. 279, Issue 2, pp. 1351-8, 2004

Lewis, Thomas, Murphy, Sampson: "Genotype and psychological phenotype in tuberous sclerosis." in: Journal of medical genetics, Vol. 41, Issue 3, pp. 203-7, 2004

Astrinidis, Senapedis, Coleman, Henske: "Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B." in: The Journal of biological chemistry, Vol. 278, Issue 51, pp. 51372-9, 2003

Images

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Supplier Images
 image for anti-TSC1 antibody (Tuberous Sclerosis 1) (pSer505) (ABIN358402) anti-Tuberous Sclerosis 1 (TSC1) (pSer505) antibody