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anti-Human TSC1 antibody for Western Blotting

Recommended TSC1 Antibody (supplied by: Log in to see )

Antigen
Tuberous Sclerosis 1 (TSC1) Antibodies
  • hamartin
  • LAM
  • mKIAA0243
  • TSC
  • tsc1
  • wu:fc38b04
Epitope
AA 401-430, Center
51
40
40
40
40
27
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
17
14
12
12
12
12
8
7
7
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
4
4
4
3
3
3
3
2
1
1
1
1
1
Reactivity
Human
424
359
153
5
1
1
1
1
1
1
Host
Rabbit
727
37
18
1
Clonality
Polyclonal
Conjugate
This TSC1 antibody is un-conjugated
67
67
67
64
64
64
3
3
3
3
3
3
3
3
3
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
532
489
152
62
33
31
17
14
7
5
4
2
1
Supplier
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Catalog No. ABIN652207
$ 324.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.12226487 ABIN501071 EIA IF WB Rabbit IgG Middle Region, both Isoforms Log in to see Polyclonal 4
0.12226487 ABIN501069 EIA WB Rabbit IgG C-Term Log in to see Polyclonal 4
0.12226487 ABIN3043497 WB Rabbit IgG AA 686-884 Log in to see Polyclonal
0.12226487 ABIN3044051 IHC (p) WB Rabbit IgG AA 1150-1164, C-Term Log in to see Polyclonal
0.12226487 ABIN593602 WB Rabbit IgG Log in to see Polyclonal
0.12226487 ABIN2466406 IHC ELISA WB Goat C-Term Log in to see Polyclonal
0.12226487 ABIN1539837 WB Mouse IgG2b Log in to see 357CT4-4-2
0.12226487 ABIN251283 IHC (p) IHC ELISA WB Goat C-Term, Isoform 1 Log in to see Polyclonal
0.12226487 ABIN1881924 WB Rabbit AA 395-424, Center, Thr417 Log in to see Polyclonal
0.12226487 ABIN2650961 IHC WB Rabbit IgG Log in to see Polyclonal
0.12226487 ABIN250696 IP WB Rabbit C-Term Log in to see Polyclonal
0.12226487 ABIN2476986 IHC (fro) IHC (p) WB Rabbit IgG Center Log in to see Polyclonal 2
0.12226487 ABIN2438267 IF IHC WB Rabbit Ig Fraction Center Log in to see Polyclonal
0.12226487 ABIN2497959 WB Mouse IgG2b Log in to see 357CT4-4-2
0.12226487 ABIN1030780 ELISA WB Rabbit C-Term Log in to see Polyclonal
0.12226487 ABIN1031146 ICC ELISA WB Rabbit Middle Region Log in to see Polyclonal
0.12226487 ABIN2500748 ELISA WB Rabbit C-Term Log in to see Polyclonal
0.12226487 ABIN2500749 ICC ELISA WB Rabbit Middle Region, both Isoforms Log in to see Polyclonal
0.12226487 ABIN3015291 IHC WB Rabbit Log in to see Polyclonal
0.12226487 ABIN2435921 IHC WB Goat Log in to see Polyclonal

Top referenced anti-TSC1 antibody for Western Blotting

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Application / Reactivity Human
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ELISA 246 Antibodies
Enzyme Immunoassay (EIA) 4 Antibodies
Flow Cytometry (FACS) 4 Antibodies
Immunochromatography (IC) 2 Antibodies
Immunocytochemistry (ICC) 14 Antibodies
Immunofluorescence (IF) 18 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 33 Antibodies
Immunohistochemistry (IHC) 64 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
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Immunoprecipitation (IP) 8 Antibodies
Western Blotting (WB) 140 Antibodies

General

Antigen Tuberous Sclerosis 1 (TSC1) Antibodies
Epitope AA 401-430, Center
(51), (40), (40), (40), (40), (27), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (17), (14), (12), (12), (12), (12), (8), (7), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (4), (4), (4), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1)
Reactivity Human
(424), (359), (153), (5), (1), (1), (1), (1), (1), (1)
Host Rabbit
(727), (37), (18), (1)
Clonality (Clone)
Polyclonal   ( )
Conjugate This TSC1 antibody is un-conjugated
(67), (67), (67), (64), (64), (64), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(532), (489), (152), (62), (33), (31), (17), (14), (7), (5), (4), (2), (1)
Pubmed 2 references available
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Product Details anti-TSC1 Antibody

Target Details TSC1 Application Details Handling References for anti-TSC1 Antibody (ABIN652207) Images
Specificity This TSC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human TSC1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen This Hamartin (TSC1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-430 AA from the Central region of human Hamartin (TSC1).
Clone RB11648
Isotype Ig

Target Details TSC1

Product Details anti-TSC1 Antibody Application Details Handling References for anti-TSC1 Antibody (ABIN652207) Images back to top
Antigen
Alternative Name Hamartin (TSC1) (TSC1 Antibody Abstract)
Background Implicated as a tumor suppressor. May have a function in vesicular transport. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Defects in TSC1 are the cause of tuberous sclerosis complex (TSC). The molecular basis of TSC is a functional impairement of the hamartin-tuberin complex. TSC is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. TSC is characterized by hamartomas (benign overgrowths predominantly of a cell or tissue type that occurs normally in the organ) and hamartias (developmental abnormalities of tissue combination). Clinical symptoms can range from benign hypopigmented macules of the skin to profound mental retardation with intractable seizures to premature death from a variety of disease-associated causes. Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC). FCDBC is a subtype of cortical displasias linked to chronic intractable epilepsy. Cortical dysplasias display a broad spectrum of structural changes, which appear to result from changes in proliferation, migration, differentiation, and apoptosis of neuronal precursors and neurons during cortical development.
Synonyms: Hamartin, Tuberous sclerosis 1 protein, TSC1, KIAA0243, TSC
Molecular Weight 129767 DA
Gene ID 7248
UniProt Q92574
Research Area Cell Structure
Pathways RTK Signaling, AMPK Signaling

Application Details

Product Details anti-TSC1 Antibody Target Details TSC1 Handling References for anti-TSC1 Antibody (ABIN652207) Images back to top
Application Notes WB = 1:1000, IHC (p) = 1:10-50, IF = 1:10-50
Restrictions For Research Use only

Handling

Product Details anti-TSC1 Antibody Target Details TSC1 Application Details References for anti-TSC1 Antibody (ABIN652207) Images back to top
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months

References for anti-TSC1 Antibody (ABIN652207)

Product Details anti-TSC1 Antibody Target Details TSC1 Application Details Handling Images back to top
Background publications

Lewis, Thomas, Murphy, Sampson: "Genotype and psychological phenotype in tuberous sclerosis." in: Journal of medical genetics, Vol. 41, Issue 3, pp. 203-7, 2004

Astrinidis, Senapedis, Coleman, Henske: "Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B." in: The Journal of biological chemistry, Vol. 278, Issue 51, pp. 51372-9, 2003

Images

Product Details anti-TSC1 Antibody Target Details TSC1 Application Details Handling References for anti-TSC1 Antibody (ABIN652207) back to top
Supplier Images
Western Blotting (WB) image for anti-TSC1 antibody (Tuberous Sclerosis 1) (AA 401-430) (ABIN652207) TSC1 Antibody (Center) (ABIN652207) western blot analysis in MDA-MB231 cell line lysa...
Immunohistochemistry (IHC) image for anti-TSC1 antibody (Tuberous Sclerosis 1) (AA 401-430) (ABIN652207) Hamartin (TSC1) Antibody (Center) (ABIN652207)immunohistochemistry analysis in formal...