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|Application / Reactivity||Rat (Rattus)||Mouse (Murine)|
|Dot Blot (DB)||76 Antibodies||247 Antibodies|
|ELISA||76 Antibodies||217 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies||2 Antibodies|
|Flow Cytometry (FACS)||2 Antibodies||3 Antibodies|
|Immunocytochemistry (ICC)||9 Antibodies||9 Antibodies|
|Immunofluorescence (IF)||9 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||39 Antibodies|
|Immunohistochemistry (IHC)||6 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||19 Antibodies|
|Immunoprecipitation (IP)||1 Antibodies|
|Western Blotting (WB)||49 Antibodies|
|Antigen||Tuberous Sclerosis 1 (TSC1) Antibodies|
|Epitope||Middle Region Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This TSC1 antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-TSC1 AntibodyTarget Details TSC1 Application Details Handling Images
|Specificity||This antibody will recognize both isoforms of TSC1.|
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
|Immunogen||TSC1 antibody was raised against Synthetic Peptide (KLH conjugated) corresponding to 15 amino acid peptide from the middle region of Human TSC1.|
Target Details TSC1Product Details anti-TSC1 Antibody Application Details Handling Images back to top
|Alternative Name||TSC1 / Hamartin (TSC1 Antibody Abstract)|
|Background||Hamartin, or TSC1, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1. It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway. TSC1 interacts with tuberin m(TSC2), which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins. The Hamartin/Tuberin complex has been shown to inhibit mTor. Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, suggesting a role for TSC proteins in modulation of cell adhesion and morphology.Synonyms: KIAA0243, TSC, Tuberous sclerosis 1 protein|
|Pathways||RTK Signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation|
Application DetailsProduct Details anti-TSC1 Antibody Target Details TSC1 Handling Images back to top
Immunocytochemistry. Western Blot (1 μg/mL). Immunohistochemistry on Paraffin Sections (2.5 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TSC1 Antibody Target Details TSC1 Application Details Images back to top
|Buffer||PBS containing 0.02 % Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C to -70 °C for longer. Dilute only prior to immediate use.|
ImagesProduct Details anti-TSC1 Antibody Target Details TSC1 Application Details Handling back to top