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Browse our anti-TSC2 (TSC2) Antibodies

Full name:
anti-Tuberous Sclerosis 2 Antibodies (TSC2)
On www.antibodies-online.com are 763 Tuberous Sclerosis 2 (TSC2) Antibodies from 25 different suppliers available. Additionally we are shipping TSC2 Kits (11) and and many more products for this protein. A total of 797 TSC2 products are currently listed.
Synonyms:
fc16b02, LAM, Nafld, Rc, Tcs2, TSC2, TSC4, tuberin, wu:fc16b02
list all antibodies Gene Name GeneID UniProt
TSC2 7249 P49815
TSC2 22084  
TSC2 24855 P49816

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All available anti-TSC2 Antibodies

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Top referenced anti-TSC2 Antibodies

  1. Human Polyclonal TSC2 Primary Antibody for EIA - ABIN358353 : Li, Inoki, Guan: Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. in Molecular and cellular biology 2004 (PubMed)
    Show all 5 references for ABIN358353

  2. Human Polyclonal TSC2 Primary Antibody for DB, EIA - ABIN358410 : Karbowniczek, Cash, Cheung, Robertson, Astrinidis, Henske: Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent. in The Journal of biological chemistry 2004 (PubMed)
    Show all 5 references for ABIN358410

  3. Human Polyclonal TSC2 Primary Antibody for DB, EIA - ABIN358369 : Corradetti, Inoki, Bardeesy, DePinho, Guan: Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. in Genes & development 2004 (PubMed)
    Show all 5 references for ABIN358369

  4. Human Polyclonal TSC2 Primary Antibody for EIA - ABIN358411 : Birchenall-Roberts, Fu, Bang, Dambach, Resau, Sadowski, Bertolette, Lee, Kim, Ruscetti: Tuberous sclerosis complex 2 gene product interacts with human SMAD proteins. A molecular link of two tumor suppressor pathways. in The Journal of biological chemistry 2004 (PubMed)
    Show all 5 references for ABIN358411

  5. Human Polyclonal TSC2 Primary Antibody for EIA, IF - ABIN501075 : Shamji, Nghiem, Schreiber: Integration of growth factor and nutrient signaling: implications for cancer biology. in Molecular cell 2003 (PubMed)
    Show all 4 references for ABIN501075

  6. Human Polyclonal TSC2 Primary Antibody for EIA, WB - ABIN501073 : Inoki, Ouyang, Li, Guan: Signaling by target of rapamycin proteins in cell growth control. in Microbiology and molecular biology reviews : MMBR 2005 (PubMed)
    Show all 4 references for ABIN501073

  7. Human Polyclonal TSC2 Primary Antibody for WB - ABIN1881945 : Dántola, Denofrio, Zurbano, Gimenez, Ogilby, Lorente, Thomas: Mechanism of photooxidation of folic acid sensitized by unconjugated pterins. in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2010 (PubMed)
    Show all 3 references for ABIN1881945

  8. Human Polyclonal TSC2 Primary Antibody for ELISA, WB - ABIN1533200 : : Identification and characterization of the tuberous sclerosis gene on chromosome 16. in Cell 1994 (PubMed)
    Show all 3 references for ABIN1533200

  9. Human Polyclonal TSC2 Primary Antibody for IHC, ELISA - ABIN1532185 : Xu, Sterner, Maheshwar, Wilson, Nellist, Short, Haines, Sampson, Ramesh: Alternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues. in Genomics 1995 (PubMed)
    Show all 2 references for ABIN1532185

More Antibodies against TSC2 Interaction Partners

Zebrafish Tuberous Sclerosis 2 (TSC2) interaction partners

  1. This is the first report using an animal model to show interactions between tsc2, mTORC1 and p53 (show TP53 Antibodies) during tumorigenesis.

  2. These results demonstrate a highly conserved role of tsc2 in zebrafish and establish a new animal model for studies of Tuberous sclerosis complex.

Human Tuberous Sclerosis 2 (TSC2) interaction partners

  1. Repression of TSC1 (show TSC1 Antibodies)/TSC2 mediated by MeCP2 (show MECP2 Antibodies) regulates human embryo lung fibroblast cell differentiation and proliferation.

  2. Novel TSC2 mutations in Chinese patients with tuberous sclerosis.

  3. Gankyrin (show PSMD10 Antibodies) overexpression activates mTORC1 signaling and accelerating TSC2 degradation in colorectal tumor cells.

  4. data provide the (show ROS1 Antibodies) first evidence that t (show NQO1 Antibodies)uberin plays a novel role in regulating ROS generation, NADPH oxidase activity, and Nox expression that may potentially be involved in development of kidney tumor in patients with tuberous sclerosis complex

  5. Our evidence suggests that variants in TSC2 exons 25 or 31 are very unlikely to cause classical TSC (show SLC12A3 Antibodies), although a role for these exons in tissue/stage specific development cannot be excluded.

  6. In children with tuberous sclerosis complex, nonsense mutations in the TSC2 gene had a correlation with autistic behavior.

  7. By interfering with TSC (show SLC12A3 Antibodies)-Rheb (show RHEB Antibodies) complex, arginine relieves allosteric inhibition of Rheb (show RHEB Antibodies) by TSC (show SLC12A3 Antibodies). Arginine cooperates with growth factor signaling which further promotes dissociation of TSC2 from lysosomes and activation of mTORC1.

  8. IQ/DQ correlates inversely with predicted levels and/or deleterious biochemical effects of mutant TSC1 (show TSC1 Antibodies) or TSC2 protein in tuberous sclerosis complex.

  9. Results confirm strong association between TSC2 mutation and angiomyolipoma burden, and they indicate that everolimus response occurs regardless of mutation type or location or when no mutation in TSC1 (show TSC1 Antibodies) or TSC2 has been identified.

  10. AKT3 (show AKT3 Antibodies) has a role in prostate cancer proliferation through regulation of Akt (show AKT1 Antibodies), B-Raf (show SNRPE Antibodies), and TSC1 (show TSC1 Antibodies)/TSC2

Mouse (Murine) Tuberous Sclerosis 2 (TSC2) interaction partners

  1. Repression of TSC1 (show TSC1 Antibodies)/TSC2 mediated by MeCP2 (show MECP2 Antibodies) regulates human embryo lung fibroblast cell differentiation and proliferation.

  2. Formation of ROS (show ROS1 Antibodies) and activity of NADPH (show FDXR Antibodies) oxidases were significantly higher in mouse embryonic fibroblasts and in primary culture of rat renal proximal tubular epithelial tuberin-deficient cells compared to wild-type cells.

  3. Data suggest that pathological cardiac hypertrophy involved class I histone deacetylases HDAC1 (show HDAC1 Antibodies) and HdAC2 (show HDAC2 Antibodies), tuberous sclerosis complex 2 (TSC2), and mTOR (show FRAP1 Antibodies) srine-threonine kinases (mTOR (show FRAP1 Antibodies)).

  4. autophagy via the TSC2-mTORC1 signaling pathway plays an important role in maintenance of cardiac function and mitochondrial quantity and size in the heart.

  5. PAK2 (show PAK2 Antibodies) is a direct effector of TSC1 (show TSC1 Antibodies)-TSC2-RHEB (show RHEB Antibodies) signaling and a new target for rational drug therapy in TSC (show SLC12A3 Antibodies).

  6. Data indicate that an AMP (show TMPRSS5 Antibodies)-ctivated kinase (AMPK (show PRKAA1 Antibodies))/cell-cycle inhibitor (show CDKN2A Antibodies) p27KIP1 (p27 (show CDKN1B Antibodies)) axis drives activation of autophagy in rapamycin-treated tuberous sclerosis 2 protein (Tsc2)-null cells.

  7. Lysosomal recruitment of TSC2 is a universal response to stimuli that inactivate mTORC1, and that the presence of any single stress is sufficient to cause TSC2 lysosomal localization.

  8. Axitinib is an effective inhibitor of Tsc2-null lesion growth.

  9. Distinct germline progenitor subsets are defined through Tsc2-mTORC1 signaling.

  10. PLK1 (show PLK1 Antibodies) protein levels are increased in hamartin (show TSC1 Antibodies) and tuberin deficient cells and Lymphangioleiomyomatosis patient-derived specimens, and that this increase is rapamycin-sensitive.

Pig (Porcine) Tuberous Sclerosis 2 (TSC2) interaction partners

  1. Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (show PRKAA1 Antibodies)/ERK (show MAPK1 Antibodies)/TSC2/mTOR (show FRAP1 Antibodies) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis

Cow (Bovine) Tuberous Sclerosis 2 (TSC2) interaction partners

  1. prostaglandin F2alpha phosphorylates TSC2 and activates mTOR (show FRAP1 Antibodies) and ribosomal protein S6 (show RPS6 Antibodies) kinase (show RPS6KB1 Antibodies) signaling in an AKT (show AKT1 Antibodies)-independent manner

TSC2 Antigen Profile

Antigen Summary

Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with TSC2

  • tuberous sclerosis 2 (TSC2) antibody
  • tuberous sclerosis complex 2 (TSC2) (AaeL_AAEL007712) antibody
  • tuberous sclerosis 2 (tsc2) antibody
  • tuberous sclerosis 2 (PGTG_00159) antibody
  • tuberous sclerosis 2 (Tsc2) antibody
  • fc16b02 antibody
  • LAM antibody
  • Nafld antibody
  • Rc antibody
  • Tcs2 antibody
  • TSC2 antibody
  • TSC4 antibody
  • tuberin antibody
  • wu:fc16b02 antibody

Protein level used designations for TSC2

tuberous sclerosis complex 2 (TSC2) , tuberous sclerosis 2 , tuberin-like , tuberin , tuberous sclerosis 2 protein , tuberous sclerosis 2 protein homolog , renal carcinoma , tuberous sclerosis 2 homolog protein

GENE ID SPECIES
100065679 Equus caballus
5569538 Aedes aegypti
468086 Pan troglodytes
567524 Danio rerio
694965 Macaca mulatta
10528144 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100170546 Xenopus (Silurana) tropicalis
100390664 Callithrix jacchus
7249 Homo sapiens
22084 Mus musculus
24855 Rattus norvegicus
479883 Canis lupus familiaris
100505408 Sus scrofa
504985 Bos taurus
416552 Gallus gallus
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