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anti-Human TSC2 Antibodies:
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Human Polyclonal TSC2 Primary Antibody for DB, IF - ABIN1881949
Li, Inoki, Guan: Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. in Molecular and cellular biology 2004
Show all 6 Pubmed References
Human Polyclonal TSC2 Primary Antibody for WB - ABIN1881945
Dántola, Denofrio, Zurbano, Gimenez, Ogilby, Lorente, Thomas: Mechanism of photooxidation of folic acid sensitized by unconjugated pterins. in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2010
Show all 3 Pubmed References
Human Polyclonal TSC2 Primary Antibody for WB - ABIN1881946
Larson, Liu, Stevens, Li, Li, Evers, Gao: Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1. in The Journal of biological chemistry 2010
Show all 3 Pubmed References
Rat (Rattus) Polyclonal TSC2 Primary Antibody for DB - ABIN1881935
Di Nardo, Kramvis, Cho, Sadowski, Meikle, Kwiatkowski, Sahin: Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Show all 3 Pubmed References
Human Polyclonal TSC2 Primary Antibody for DB - ABIN1881948
Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: A Large-scale genetic association study of esophageal adenocarcinoma risk. in Carcinogenesis 2010
Show all 3 Pubmed References
Human Monoclonal TSC2 Primary Antibody for ICC, IF - ABIN256563
Wang, Chen, Kuo, Su, Lai, Wang, Huang, Hoffman, Kuo, You, Chuang: Zebrafish Thsd7a is a neural protein required for angiogenic patterning during development. in Developmental dynamics : an official publication of the American Association of Anatomists 2011
Show all 2 Pubmed References
Human Polyclonal TSC2 Primary Antibody for IF (p), IHC (p) - ABIN701200
Wang, Chen, Deng, Bian, Huang, Lei, Lv, Liu, Li: Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation. in International journal of biological macromolecules 2017
This is the first report using an animal model to show interactions between tsc2, mTORC1 and p53 (show TP53 Antibodies) during tumorigenesis.
These results demonstrate a highly conserved role of tsc2 in zebrafish and establish a new animal model for studies of Tuberous sclerosis complex.
Mutations in MTOR (show FRAP1 Antibodies), TSC1 (show TSC1 Antibodies), or TSC2 were more common in patients who experienced clinical benefit from rapalogs than in those who progressed.
The findings establish an active role for Tsc1 (show TSC1 Antibodies) as a facilitator of Hsp90 (show HSP90 Antibodies)-mediated folding of kinase and non-kinase clients-including Tsc2-thereby preventing their ubiquitination and proteasomal degradation.
In our series, consistent with other studies, TSC2 mutations were associated with a more severe phenotypic spectrum than TSC1 (show TSC1 Antibodies) mutations. This is the first study that sought to characterize the molecular spectrum of Brazilian individuals with tuberous sclerosis
Functional validation of the oncogenic cooperativity and targeting potential of tuberous sclerosis mutation in medulloblastoma using a MYC (show MYC Antibodies)-amplified model cell line
This case provides evidence for a unique TSC2 mutation that resulted in an atypical clinical presentation and indicates potential shortcomings of the current diagnostic criteria for TSC (show SLC12A3 Antibodies). These findings may have implications for genetic counseling and screening.
we report a pathogenic TSC2 variant, c.1864C>T, p.(Arg622Trp), associated with a mild phenotype, with most carriers meeting fewer than two major clinical diagnostic criteria for TSC (show SLC12A3 Antibodies). This finding has significant implications for counseling patients regarding prognosis.
The results highlight a new role of TSC2 in protecting glioblastoma against photodynamic therapy-induced cell death, and TSC2 and YWHAZ (show YWHAZ Antibodies) as new RIP3 (show RIPK3 Antibodies) partners.
Study provides new information regarding cerebellar lesions in tuberous sclerosis complex: cerebellar lesions are significantly much more frequent in patients with TSC2 mutations than TSC1 (show TSC1 Antibodies) mutations or patients with no mutation identified, and Crus II is the most frequent location of cerebellar lesions.
Two pathogenic mutations in TSC1 (show TSC1 Antibodies) and one in TSC2 genes were identified in patients with tuberous sclerosis complex; the patient with TSC2 mutation manifested a more severe clinical phenotype
Novel missense mutation in the exon 19 of the TSC2 gene is associated with tuberous sclerosis.
Lymphangioleiomyomatosis is fatal lung disease associated with germline/somatic inactivating mutations in TSC2 genes. Data suggest lung lymphangioleiomyomatosis lesions and renal angiomyolipomas overexpress uPA (show PLAU Antibodies); Tsc2-/- (or Tsc1 (show TSC1 Antibodies)-/-) embryonic fibroblasts from knockout mice express higher uPA (show PLAU Antibodies) levels than wild-type cells. (uPA (show PLAU Antibodies) = urokinase-type plasminogen activator (show PLAU Antibodies); Tsc (show SLC12A3 Antibodies) = tuberous sclerosis complex protein)
Loss of the tuberous sclerosis complex (TSC (show SLC12A3 Antibodies)) tumor suppressors results in activation of mTORC1 and development of the tumor syndrome tuberous sclerosis complex (TSC (show SLC12A3 Antibodies)).
Tsc2-mTOR (show FRAP1 Antibodies) signaling in mesenchyme is essential for the maintenance of renal structure and for lung alveolarization.
TSC1 (show TSC1 Antibodies)/TSC2 complex upregulation of OPN (show SPP1 Antibodies) expression is mediated by transcription factor SOX9 (show SOX9 Antibodies) in an mTOR (show FRAP1 Antibodies)-independent manner. Moreover, ablation of OPN (show SPP1 Antibodies) by deficient TSC1 (show TSC1 Antibodies)/TSC2 complex contributed to inactivation of AKT (show AKT1 Antibodies) in TSC (show SLC12A3 Antibodies) cells
Rheb (show RHEB Antibodies) and TSC2 have roles in the mechanical activation of mTOR (show FRAP1 Antibodies) signaling
this study shows that TSC2 maintains macrophage quiescence and prevents mTORC1-dependent granulomatous disease with clinical implications for sarcoidosis
TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy/cell proliferation.
Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation.
Formation of ROS (show ROS1 Antibodies) and activity of NADPH (show FDXR Antibodies) oxidases were significantly higher in mouse embryonic fibroblasts and in primary culture of rat renal proximal tubular epithelial tuberin-deficient cells compared to wild-type cells.
Data suggest that pathological cardiac hypertrophy involved class I histone deacetylases HDAC1 (show HDAC1 Antibodies) and HdAC2 (show HDAC2 Antibodies), tuberous sclerosis complex 2 (TSC2), and mTOR (show FRAP1 Antibodies) srine-threonine kinases (mTOR (show FRAP1 Antibodies)).
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (show PRKAA1 Antibodies)/ERK (show MAPK1 Antibodies)/TSC2/mTOR (show FRAP1 Antibodies) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
prostaglandin F2alpha phosphorylates TSC2 and activates mTOR (show FRAP1 Antibodies) and ribosomal protein S6 (show RPS6 Antibodies) kinase (show RPS6KB1 Antibodies) signaling in an AKT (show AKT1 Antibodies)-independent manner
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.
tuberous sclerosis complex 2 (TSC2)
, tuberous sclerosis 2
, tuberous sclerosis 2 protein
, tuberous sclerosis 2 protein homolog
, renal carcinoma
, tuberous sclerosis 2 homolog protein