Browse our anti-TSC2 (TSC2) Antibodies

Full name:
anti-Tuberous Sclerosis 2 Antibodies (TSC2)
On www.antibodies-online.com are 746 Tuberous Sclerosis 2 (TSC2) Antibodies from 26 different suppliers available. Additionally we are shipping TSC2 Kits (14) and and many more products for this protein. A total of 783 TSC2 products are currently listed.
Synonyms:
fc16b02, LAM, Nafld, Rc, Tcs2, TSC2, TSC4, tuberin, wu:fc16b02
list all antibodies Gene Name GeneID UniProt
TSC2 7249 P49815
TSC2 22084  
TSC2 24855 P49816

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Top referenced anti-TSC2 Antibodies

  1. Human Polyclonal TSC2 Primary Antibody for DB, IF - ABIN1881949 : Li, Inoki, Guan: Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. in Molecular and cellular biology 2004 (PubMed)
    Show all 6 references for 1881949

  2. Human Polyclonal TSC2 Primary Antibody for EIA - ABIN358411 : Karbowniczek, Cash, Cheung, Robertson, Astrinidis, Henske: Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent. in The Journal of biological chemistry 2004 (PubMed)
    Show all 5 references for 358411

  3. Human Polyclonal TSC2 Primary Antibody for DB, EIA - ABIN358410 : Corradetti, Inoki, Bardeesy, DePinho, Guan: Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. in Genes & development 2004 (PubMed)
    Show all 5 references for 358410

  4. Human Polyclonal TSC2 Primary Antibody for DB, EIA - ABIN358369 : Birchenall-Roberts, Fu, Bang, Dambach, Resau, Sadowski, Bertolette, Lee, Kim, Ruscetti: Tuberous sclerosis complex 2 gene product interacts with human SMAD proteins. A molecular link of two tumor suppressor pathways. in The Journal of biological chemistry 2004 (PubMed)
    Show all 5 references for 358369

  5. Human Polyclonal TSC2 Primary Antibody for EIA - ABIN358353 : Lewis, Thomas, Murphy, Sampson: Genotype and psychological phenotype in tuberous sclerosis. in Journal of medical genetics 2004 (PubMed)
    Show all 5 references for 358353

  6. Human Polyclonal TSC2 Primary Antibody for WB - ABIN1881945 : Dántola, Denofrio, Zurbano, Gimenez, Ogilby, Lorente, Thomas: Mechanism of photooxidation of folic acid sensitized by unconjugated pterins. in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2010 (PubMed)
    Show all 3 references for 1881945

  7. Human Polyclonal TSC2 Primary Antibody for DB - ABIN1881948 : Larson, Liu, Stevens, Li, Li, Evers, Gao: Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1. in The Journal of biological chemistry 2010 (PubMed)
    Show all 3 references for 1881948

  8. Human Polyclonal TSC2 Primary Antibody for ELISA, WB - ABIN1533200 : : Identification and characterization of the tuberous sclerosis gene on chromosome 16. in Cell 1994 (PubMed)
    Show all 3 references for 1533200

  9. Human Polyclonal TSC2 Primary Antibody for IHC, ELISA - ABIN1532185 : Xu, Sterner, Maheshwar, Wilson, Nellist, Short, Haines, Sampson, Ramesh: Alternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues. in Genomics 1995 (PubMed)
    Show all 2 references for 1532185

  10. Human Polyclonal TSC2 Primary Antibody for IF (p), IHC (p) - ABIN701200 : Wang, Chen, Deng, Bian, Huang, Lei, Lv, Liu, Li: Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation. in International journal of biological macromolecules 2017 (PubMed)

More Antibodies against TSC2 Interaction Partners

Zebrafish Tuberous Sclerosis 2 (TSC2) interaction partners

  1. This is the first report using an animal model to show interactions between tsc2, mTORC1 and p53 (show TP53 Antibodies) during tumorigenesis.

  2. These results demonstrate a highly conserved role of tsc2 in zebrafish and establish a new animal model for studies of Tuberous sclerosis complex.

Human Tuberous Sclerosis 2 (TSC2) interaction partners

  1. Novel missense mutation in the exon 19 of the TSC2 gene is associated with tuberous sclerosis.

  2. our findings suggest the significance of previously undocumented mutation-dependent mTOR (show FRAP1 Antibodies) hyperactivation and frequent TSC1 (show TSC1 Antibodies)/2 mutations in HBV-associated HCCs (show HCCS Antibodies). They define a molecular subset of HCC (show FAM126A Antibodies) having genetic aberrations in mTOR (show FRAP1 Antibodies) signalling, with potential significance of effective specific drug therapy.

  3. Mutation in TSC2 is associated with lymphangioleiomyomatosis.

  4. Results show that tuberous sclerosis complex disease segregates with a silent substitution in TSC2, c.4149C>T, p.(Ser1838Ser), which leads to the formation of an active donor splice site, resulting in three shorter alternatively spliced transcripts with premature stop codons.

  5. Clinical whole exome sequencing of blood and tumor samples con (show DISP1 Antibodies) fi rmed the diagnosis of methylmalonic acidemia and revealed two somatic inactivating mutations in TSC2, suggesting the potential consideration of an mTOR (show FRAP1 Antibodies) inhibitor in the event of tumor recurrence.

  6. TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy/cell proliferation.

  7. The mTOR (show FRAP1 Antibodies)-dependent, epithelial phenotype of TSC (show SLC12A3 Antibodies) astrocytes suggests TSC1 (show TSC1 Antibodies)/2 and mTOR (show FRAP1 Antibodies) tune the phosphorylation level of catenin delta-1 (show CTNND1 Antibodies) by controlling PKCe (show PRKCE Antibodies) activity, thereby regulating the mesenchymal-epithelial-transition (MET)

  8. TSC2 mutations leading to severe tuberous sclerosis in Chinese children.

  9. Our results indicate that TSC2 and less commonly TSC1 (show TSC1 Antibodies) alterations are the primary essential driver event in angiomyolipoma/Lymphangioleiomyomatosis, whereas other somatic mutations are rare and likely do not contribute to tumor development.

  10. These results suggested that TSC2 heterozygosity caused neurological malformations in primitive neural stem cells, indicating that its heterozygosity might be sufficient for the development of neurological abnormalities in patients.

Mouse (Murine) Tuberous Sclerosis 2 (TSC2) interaction partners

  1. Tsc2-mTOR (show FRAP1 Antibodies) signaling in mesenchyme is essential for the maintenance of renal structure and for lung alveolarization.

  2. TSC1 (show TSC1 Antibodies)/TSC2 complex upregulation of OPN (show SPP1 Antibodies) expression is mediated by transcription factor SOX9 (show SOX9 Antibodies) in an mTOR (show FRAP1 Antibodies)-independent manner. Moreover, ablation of OPN (show SPP1 Antibodies) by deficient TSC1 (show TSC1 Antibodies)/TSC2 complex contributed to inactivation of AKT (show AKT1 Antibodies) in TSC (show SLC12A3 Antibodies) cells

  3. Rheb (show RHEB Antibodies) and TSC2 have roles in the mechanical activation of mTOR (show FRAP1 Antibodies) signaling

  4. this study shows that TSC2 maintains macrophage quiescence and prevents mTORC1-dependent granulomatous disease with clinical implications for sarcoidosis

  5. TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy/cell proliferation.

  6. Repression of TSC1 (show TSC1 PLURAL_@4252@)/TSC2 mediated by MeCP2 (show MECP2 PLURAL_@4252@) regulates human embryo lung fibroblast cell differentiation and proliferation.

  7. Formation of ROS (show ROS1 Antibodies) and activity of NADPH (show FDXR Antibodies) oxidases were significantly higher in mouse embryonic fibroblasts and in primary culture of rat renal proximal tubular epithelial tuberin-deficient cells compared to wild-type cells.

  8. Data suggest that pathological cardiac hypertrophy involved class I histone deacetylases HDAC1 (show HDAC1 Antibodies) and HdAC2 (show HDAC2 Antibodies), tuberous sclerosis complex 2 (TSC2), and mTOR (show FRAP1 Antibodies) srine-threonine kinases (mTOR (show FRAP1 Antibodies)).

  9. autophagy via the TSC2-mTORC1 signaling pathway plays an important role in maintenance of cardiac function and mitochondrial quantity and size in the heart.

  10. PAK2 (show PAK2 Antibodies) is a direct effector of TSC1 (show TSC1 Antibodies)-TSC2-RHEB (show RHEB Antibodies) signaling and a new target for rational drug therapy in TSC (show SLC12A3 Antibodies).

Pig (Porcine) Tuberous Sclerosis 2 (TSC2) interaction partners

  1. Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (show PRKAA1 Antibodies)/ERK (show MAPK1 Antibodies)/TSC2/mTOR (show FRAP1 Antibodies) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis

Cow (Bovine) Tuberous Sclerosis 2 (TSC2) interaction partners

  1. prostaglandin F2alpha phosphorylates TSC2 and activates mTOR (show FRAP1 Antibodies) and ribosomal protein S6 (show RPS6 Antibodies) kinase (show RPS6KB1 Antibodies) signaling in an AKT (show AKT1 Antibodies)-independent manner

TSC2 Antigen Profile

Antigen Summary

Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with TSC2

  • tuberous sclerosis 2 (TSC2) antibody
  • tuberous sclerosis complex 2 (TSC2) (AaeL_AAEL007712) antibody
  • tuberous sclerosis 2 (tsc2) antibody
  • tuberous sclerosis 2 (PGTG_00159) antibody
  • tuberous sclerosis 2 (Tsc2) antibody
  • fc16b02 antibody
  • LAM antibody
  • Nafld antibody
  • Rc antibody
  • Tcs2 antibody
  • TSC2 antibody
  • TSC4 antibody
  • tuberin antibody
  • wu:fc16b02 antibody

Protein level used designations for TSC2

tuberous sclerosis complex 2 (TSC2) , tuberous sclerosis 2 , tuberin-like , tuberin , tuberous sclerosis 2 protein , tuberous sclerosis 2 protein homolog , renal carcinoma , tuberous sclerosis 2 homolog protein

GENE ID SPECIES
100065679 Equus caballus
5569538 Aedes aegypti
468086 Pan troglodytes
567524 Danio rerio
694965 Macaca mulatta
10528144 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100170546 Xenopus (Silurana) tropicalis
100390664 Callithrix jacchus
7249 Homo sapiens
22084 Mus musculus
24855 Rattus norvegicus
479883 Canis lupus familiaris
100505408 Sus scrofa
504985 Bos taurus
416552 Gallus gallus
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