anti-Human TSC2 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended TSC2 Antibody (supplied by: Log in to see )

Antigen
Tuberous Sclerosis 2 (TSC2) Antibodies
  • TSC2
  • fc16b02
  • tuberin
  • wu:fc16b02
  • LAM
  • TSC4
  • Nafld
  • Tcs2
  • Rc
  • tuberous sclerosis 2
  • tuberous sclerosis complex 2 (TSC2)
  • TSC2
  • AaeL_AAEL007712
  • tsc2
  • PGTG_00159
  • Tsc2
Epitope
AA 1600-1650
57
41
40
36
33
30
29
25
21
21
20
20
20
20
20
20
20
20
20
20
18
15
15
15
15
14
13
8
8
8
7
7
6
5
4
4
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
558
412
242
13
9
4
4
3
1
1
1
1
Host
Rabbit
727
26
Clonality
Polyclonal
Conjugate
This TSC2 antibody is un-conjugated
51
51
51
43
42
42
10
10
9
9
9
9
9
9
9
9
9
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
396
287
231
143
118
94
68
24
7
7
5
4
2
1
Options
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Catalog No. ABIN701200
$ 295.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN712121 IF (p) IHC (p) WB Rabbit IgG pSer1798 Log in to see Polyclonal
1 ABIN2807295 IF (p) Alexa Fluor 594 Rabbit IgG AA 1600-1650 Log in to see Polyclonal
1 ABIN701203 IF (p) Cy3 Rabbit IgG AA 1600-1650 Log in to see Polyclonal
1 ABIN701204 IF (p) Cy5 Rabbit IgG AA 1600-1650 Log in to see Polyclonal
1 ABIN701205 IF (p) Cy5.5 Rabbit IgG AA 1600-1650 Log in to see Polyclonal
1 ABIN701206 IF (p) Cy7 Rabbit IgG AA 1600-1650 Log in to see Polyclonal
1 ABIN701207 IF (p) FITC Rabbit IgG AA 1600-1650 Log in to see Polyclonal
1 ABIN918955 IF (p) Alexa Fluor 350 Rabbit IgG AA 1600-1650 Log in to see Polyclonal
1 ABIN918957 IF (p) Alexa Fluor 647 Rabbit IgG AA 1600-1650 Log in to see Polyclonal
1 ABIN918956 IF (p) Alexa Fluor 488 Rabbit IgG AA 1600-1650 Log in to see Polyclonal
1 ABIN918954 IF (p) Alexa Fluor 555 Rabbit IgG AA 1600-1650 Log in to see Polyclonal
1 ABIN2807292 IF (p) Alexa Fluor 594 Rabbit IgG pSer1387 Log in to see Polyclonal
1 ABIN2807294 IF (p) Alexa Fluor 594 Rabbit IgG pSer1254 Log in to see Polyclonal
1 ABIN2807293 IF (p) Alexa Fluor 594 Rabbit IgG pThr927 Log in to see Polyclonal
1 ABIN746382 IF (p) Cy5 Rabbit IgG pSer1387 Log in to see Polyclonal
1 ABIN746383 IF (p) Cy5.5 Rabbit IgG pSer1387 Log in to see Polyclonal
1 ABIN746384 IF (p) Cy7 Rabbit IgG pSer1387 Log in to see Polyclonal
1 ABIN746385 IF (p) FITC Rabbit IgG pSer1387 Log in to see Polyclonal
1 ABIN746441 IF (p) Cy3 Rabbit IgG pThr927 Log in to see Polyclonal
1 ABIN746444 IF (p) Cy7 Rabbit IgG pThr927 Log in to see Polyclonal

General

Antigen Tuberous Sclerosis 2 (TSC2) Antibodies
Epitope AA 1600-1650
(57), (41), (40), (36), (33), (30), (29), (25), (21), (21), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (18), (15), (15), (15), (15), (14), (13), (8), (8), (8), (7), (7), (6), (5), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(558), (412), (242), (13), (9), (4), (4), (3), (1), (1), (1), (1)
Host Rabbit
(727), (26)
Clonality
Polyclonal
Conjugate This TSC2 antibody is un-conjugated
(51), (51), (51), (43), (42), (42), (10), (10), (9), (9), (9), (9), (9), (9), (9), (9), (9), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(396), (287), (231), (143), (118), (94), (68), (24), (7), (7), (5), (4), (2), (1)
Pubmed 1 reference available
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Product Details anti-TSC2 Antibody

Target Details TSC2 Application Details Handling References for anti-TSC2 antibody (ABIN701200) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Tuberin
Isotype IgG

Target Details TSC2

Product Details anti-TSC2 Antibody Application Details Handling References for anti-TSC2 antibody (ABIN701200) Images back to top
Antigen
Alternative Name Tuberin (TSC2 Antibody Abstract)
Background

In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.

Subcellular location: Cytoplasm

Synonyms: LAM, TSC4, PPP1R160, Tuberin, Tuberous sclerosis 2 protein, TSC2

Gene ID 7249
UniProt P49815
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Pathways RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus

Application Details

Product Details anti-TSC2 Antibody Target Details TSC2 Handling References for anti-TSC2 antibody (ABIN701200) Images back to top
Application Notes IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-TSC2 Antibody Target Details TSC2 Application Details References for anti-TSC2 antibody (ABIN701200) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-TSC2 antibody (ABIN701200)

Product Details anti-TSC2 Antibody Target Details TSC2 Application Details Handling Images back to top
Product cited in:

Wang, Chen, Deng, Bian, Huang, Lei, Lv, Liu, Li: "Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation." in: International journal of biological macromolecules, Vol. 96, pp. 578-588, 2017 Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Mouse (Murine)).

Images

Product Details anti-TSC2 Antibody Target Details TSC2 Application Details Handling References for anti-TSC2 antibody (ABIN701200) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Tuberous Sclerosis 2 (TSC2) (AA 1600-1650) antibody (ABIN701200) Formalin-fixed and paraffin embedded human endometrial tissue labeled with Anti-Tuber...
Immunohistochemistry (IHC) image for anti-Tuberous Sclerosis 2 (TSC2) (AA 1600-1650) antibody (ABIN701200) Formalin-fixed and paraffin embedded human gastric adenocarcinoma tissue labeled with...
Immunohistochemistry (IHC) image for anti-Tuberous Sclerosis 2 (TSC2) (AA 1600-1650) antibody (ABIN701200) Formalin-fixed and paraffin embedded rat brain tissue labeled withAnti-Tuberin/TSC2 P...