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anti-Human TSC2 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended TSC2 Antibody (supplied by: Log in to see )

Antigen
Tuberous Sclerosis 2 (TSC2) Antibodies
  • fc16b02
  • LAM
  • Nafld
  • Rc
  • Tcs2
  • TSC2
  • TSC4
  • tuberin
  • wu:fc16b02
Epitope
Ser1798
41
40
34
28
27
26
24
23
22
22
20
20
20
20
20
20
20
20
20
19
18
17
16
15
15
15
13
13
13
13
11
8
8
6
6
6
6
6
6
6
6
6
6
5
4
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
523
378
209
6
Host
Rabbit
697
24
Clonality
Polyclonal
Conjugate
This TSC2 antibody is un-conjugated
51
51
51
43
42
42
10
10
9
9
9
9
9
9
9
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
387
291
219
148
101
74
63
24
7
6
4
2
1
Supplier
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Catalog No. ABIN358936
$ 401.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.34253615 ABIN498903 IHC (p) Rabbit Log in to see Polyclonal
0.34253615 ABIN498904 IHC (p) Rabbit Log in to see Polyclonal
0.34253615 ABIN498905 IHC (p) Rabbit Log in to see Polyclonal
0.34253615 ABIN218353 IF IHC (p) Rabbit IgG pSer664 Log in to see Polyclonal
0.34253615 ABIN498813 IHC (p) Rabbit pSer939 Log in to see Polyclonal
0.34253615 ABIN498812 IHC (p) Rabbit pSer1254 Log in to see Polyclonal
0.34253615 ABIN498814 IHC (p) Rabbit pThr1462 Log in to see Polyclonal
0.34253615 ABIN712121 IF (p) IHC (p) WB Rabbit IgG pSer1798 Log in to see Polyclonal
0.34253615 ABIN214015 IHC (p) WB Rabbit C-Term Log in to see Polyclonal
0.0008985059 ABIN272089 IHC (p) WB Rabbit Log in to see Polyclonal
0.0008985059 ABIN272090 IHC (p) Rabbit Log in to see Polyclonal
0.0008985059 ABIN390324 IF IHC (p) WB Rabbit Ig AA 1776-1805, Ser1798 Log in to see Polyclonal
0.0008985059 ABIN3043498 IHC (p) WB Rabbit IgG AA 1611-1807 Log in to see Polyclonal
0.0008985059 ABIN2888710 IF IHC (p) ELISA WB Rabbit IgG AA 905-954 Log in to see Polyclonal
0.0008985059 ABIN302895 IHC (p) WB Rabbit Log in to see Polyclonal
0.0008985059 ABIN303312 IF IHC (p) WB Rabbit N-Term Log in to see Polyclonal
0.0008985059 ABIN701200 IF (p) IHC (p) Rabbit IgG AA 1600-1650 Log in to see Polyclonal
0.0008985059 ABIN214540 ICC IHC (p) WB Rabbit N-Term Log in to see Polyclonal
0.0008985059 ABIN2888711 IHC (p) ELISA Rabbit IgG AA 1428-1477 Log in to see Polyclonal
0.0008985059 ABIN256563 ICC IF IHC (p) IHC Rabbit IgG pSer664 Log in to see Poly6359

Top referenced anti-TSC2 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Similar anti-TSC2 Antibodies

Application / Reactivity Human
Dot Blot (DB) 120 Antibodies
ELISA 255 Antibodies
ELISA (Capture) 1 Antibodies
Enzyme Immunoassay (EIA) 7 Antibodies
Flow Cytometry (FACS) 2 Antibodies
Immunochromatography (IC) 4 Antibodies
Immunocytochemistry (ICC) 26 Antibodies
Immunofluorescence (IF) 61 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 101 Antibodies
Immunohistochemistry (IHC) 153 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 80 Antibodies
Immunoprecipitation (IP) 7 Antibodies
Western Blotting (WB) 206 Antibodies

General

Antigen Tuberous Sclerosis 2 (TSC2) Antibodies
Epitope Ser1798
(41), (40), (34), (28), (27), (26), (24), (23), (22), (22), (20), (20), (20), (20), (20), (20), (20), (20), (20), (19), (18), (17), (16), (15), (15), (15), (13), (13), (13), (13), (11), (8), (8), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(523), (378), (209), (6)
Host Rabbit
(697), (24)
Clonality
Polyclonal
Conjugate This TSC2 antibody is un-conjugated
(51), (51), (51), (43), (42), (42), (10), (10), (9), (9), (9), (9), (9), (9), (9), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(387), (291), (219), (148), (101), (74), (63), (24), (7), (6), (4), (2), (1)
Pubmed 4 references available
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Product Details anti-TSC2 Antibody

Target Details TSC2 Application Details Handling References for anti-TSC2 Antibody (ABIN358936) Images
Specificity This antibody reacts to Tuberin (TSC2).
Purification Protein A column, followed by peptide affinity purification
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S1798 of human TSC2.
Isotype Ig

Target Details TSC2

Product Details anti-TSC2 Antibody Application Details Handling References for anti-TSC2 Antibody (ABIN358936) Images back to top
Antigen
Alternative Name Tuberin / TSC2 (TSC2 Antibody Abstract)
Background Mutations in TSC2 lead to tuberous sclerosis complex. This protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. It may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.Synonyms: TSC4, Tuberous sclerosis 2 protein
Gene ID 7249, 9606
UniProt P49815
Pathways RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-TSC2 Antibody Target Details TSC2 Handling References for anti-TSC2 Antibody (ABIN358936) Images back to top
Application Notes ELISA: 1/1,000. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-TSC2 Antibody Target Details TSC2 Application Details References for anti-TSC2 Antibody (ABIN358936) Images back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References for anti-TSC2 Antibody (ABIN358936)

Product Details anti-TSC2 Antibody Target Details TSC2 Application Details Handling Images back to top
Background publications

Li, Inoki, Guan: "Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity." in: Molecular and cellular biology, Vol. 24, Issue 18, pp. 7965-75, 2004

Karbowniczek, Cash, Cheung, Robertson, Astrinidis, Henske: "Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent." in: The Journal of biological chemistry, Vol. 279, Issue 29, pp. 29930-7, 2004

Corradetti, Inoki, Bardeesy, DePinho, Guan: "Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome." in: Genes & development, Vol. 18, Issue 13, pp. 1533-8, 2004

Birchenall-Roberts, Fu, Bang, Dambach, Resau, Sadowski, Bertolette, Lee, Kim, Ruscetti: "Tuberous sclerosis complex 2 gene product interacts with human SMAD proteins. A molecular link of two tumor suppressor pathways." in: The Journal of biological chemistry, Vol. 279, Issue 24, pp. 25605-13, 2004

Images

Product Details anti-TSC2 Antibody Target Details TSC2 Application Details Handling References for anti-TSC2 Antibody (ABIN358936) back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-TSC2 antibody (Tuberous Sclerosis 2) (Ser1798) (ABIN358936) Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with TSC2 A...