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anti-Human TYRO3 Antibodies:
anti-Rat (Rattus) TYRO3 Antibodies:
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Human Monoclonal TYRO3 Primary Antibody for FACS - ABIN4897539
Gould, Baxi, Schroeder, Peng, Leadley, Peterson, Perrin: Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses. in Journal of thrombosis and haemostasis : JTH 2005
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Human Monoclonal TYRO3 Primary Antibody for IF, ELISA - ABIN967221
Janssen, Schulz, Steenvoorden, Schmidberger, Strehl, Ambros, Bartram: A novel putative tyrosine kinase receptor with oncogenic potential. in Oncogene 1991
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Mouse (Murine) Monoclonal TYRO3 Primary Antibody for CyTOF, ELISA (Capture) - ABIN4900191
Fujimori, Grabiec, Kaur, Bell, Fujino, Cook, Svedberg, MacDonald, Maciewicz, Singh, Hussell: The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung. in Mucosal immunology 2015
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Human Monoclonal TYRO3 Primary Antibody for ICC, ELISA - ABIN1724702
Hafizi, Gustafsson, Stenhoff, Dahlbäck: The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases. in The international journal of biochemistry & cell biology 2005
Human Polyclonal TYRO3 Primary Antibody for FACS, ICC - ABIN440474
Chan, Carrera Silva, De Kouchkovsky, Joannas, Hao, Hu, Huntsman, Eng, Licona-Limón, Weinstein, Herbert, Craft, Flavell, Repetto, Correale, Burchard, Torgerson, Ghosh, Rothlin: The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. in Science (New York, N.Y.) 2016
Human Monoclonal TYRO3 Primary Antibody for ELISA, WB - ABIN967222
Heiring, Dahlbäck, Muller: Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family. in The Journal of biological chemistry 2004
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Human Monoclonal TYRO3 Primary Antibody for ELISA, WB - ABIN969449
Lan, Wu, Li, Wu, Lu, Xu, Dai: Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway. in Blood 2000
Patients with macroalbuminuria diabetes had higher circulating levels of sMer and more urinary soluble Tyro3 and sMer than normoalbuminuric diabetics. Increased clearance of sTyro3 and sMer was associated with loss of tubular Tyro3 and Mer (show MERTK Antibodies) expression in diabetic nephropathy tissue. During in vitro diabetes, human kidney cells had down-regulation of Tyro3 and Mer (show MERTK Antibodies) mRNA and increased shedding of sTyro3 and sMer.
TYRO3 is overexpressed in the early stage of colon cancer development and aberrant expression of TYRO3 promotes tumorigenesis and induces EMT (show ITK Antibodies) through the regulation of SNAI1 (show SNAI1 Antibodies).
In this paper, we review the biology of the Gas6 (show GAS6 Antibodies)/Tyro3, Axl (show AXL Antibodies), and MerTK (show MERTK Antibodies)(collectively named TAM (show CCNA1 Antibodies) system)and the current evidence supporting its potential role in the pathogenesis of multiple sclerosis .
these data suggest that Tyro3 contributes significantly to tumor growth, aggressiveness and liver dysfunction
Tyro3 gene dosage modulates Mertk (show MERTK Antibodies)-associated retinal degeneration, provide strong evidence for a direct role for TYRO3 in RPE (show RPE Antibodies) phagocytosis, and suggest that an eQTL (show EQTN Antibodies) can modify a recessive Inherited photoreceptor degenerations.
The mRNA expression levels of Tyro-3, Axl (show AXL Antibodies) were decreased in pSS (show CDSN Antibodies) patients. When considering the plasma level, increased levels of soluble Mer (show MERTK Antibodies) was observed with statistically significant difference.
genetic ablation of a receptor tyrosine kinase (show RET Antibodies) encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity.
the results of the present study demonstrated that the acquired taxol resistance of ovarian cancer cells was associated with ROS (show ROS1 Antibodies)-dependent upregulation in the expression of Tyro3 RTK and the subsequent activation of Akt (show AKT1 Antibodies).
Tetherin (show BST2 Antibodies) phosphorylation induces the recruitment of Syk (show SYK Antibodies) which is required for downstream NF-kappaB (show NFKB1 Antibodies) activation.
These studies demonstrate that, despite their similarity, TYRO3, AXL, and MER are likely to perform distinct functions in both immunoregulation and the recognition and removal of ACs.
This study mapped the autophosphorylation sites of murine Tyro3 to tyrosine 723 and 756, with K540 being required for its kinase activity.
Axl (show AXL Antibodies), Mertk (show MERTK Antibodies) and Tyro3 receptors are not required for Zika virus entry and infection.
genetic ablation of a receptor tyrosine kinase (show ERBB3 Antibodies) encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity.
These results suggest that TAM (show CCNA1 Antibodies) receptors support NSCs survival, proliferation and differentiation by regulating expression of neurotrophins, especially the nerve growth factor.
Optimal TAM (show CCNA1 Antibodies) signaling requires coincident TAM (show CCNA1 Antibodies) ligand engagement of both its receptor and the phospholipid phosphatidylserine regulating TAM (show CCNA1 Antibodies) receptor tyrosine kinases Tyro3, Axl (show AXL Antibodies), and Mer (show ERH Antibodies) and their ligands Gas6 (show GAS6 Antibodies) and Protein S.
These findings indicate that Tyro3 is a critical signal for synovial hyperplasia, osteoclast differentiation and bone erosion during arthritis.
Axl (show AXL Antibodies) and Mer (show ERH Antibodies) (TAM (show CCNA1 Antibodies)) receptor tyrosine kinases (RTKs) developed persistent inflammatory liver damage resembling AIH. Tyro3(-/-)Axl (show AXL Antibodies)(-/-)Mer (show ERH Antibodies)(-/-) triple mutant (TAM (show CCNA1 Antibodies)(-/-)) mice exhibited chronic hepatitis
Adult brain neurogenesis is reduced in the hippocampus of the Tyro3-/-Axl (show AXL Antibodies)-/-Mertk (show MERTK Antibodies)-/- triple-knockout but not in single Tyro3-/- knockouts.
Chronic systemic inflammation and autoimmune disorders in the Tyro3, Axl (show AXL Antibodies) and Mertk (show MERTK Antibodies) knockout mice cause neuronal damage and death.
The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses.
TYRO3 protein tyrosine kinase
, Tyrosine-protein kinase receptor TYRO3
, tyrosine-protein kinase receptor TYRO3
, developmental receptor tyrosine kinase
, tyrosine-protein kinase DTK
, tyrosine-protein kinase receptor TYRO3-like
, tyrosine-protein kinase RSE
, tyrosine-protein kinase SKY
, tyrosine-protein kinase TIF
, tyrosine-protein kinase byk
, Bruton agammaglobulinemia tyrosine kinase
, TYRO3 protein tyrosine kinase 3
, Axl-related receptor tyrosine kinase
, protein-tyrosine kinase
, retina-expressed kinase
, Xenopus kinase of Sky family
, tyrosine kinase