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|Application / Reactivity||Human|
|Blocking Reagent (BR)||1 Antibodies|
|Enzyme Immunoassay (EIA)||20 Antibodies|
|Flow Cytometry (FACS)||1 Antibodies|
|Functional Studies (Func)||11 Antibodies|
|Immunocytochemistry (ICC)||6 Antibodies|
|Immunofluorescence (IF)||7 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||22 Antibodies|
|Immunohistochemistry (IHC)||43 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||7 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||51 Antibodies|
|Immunoprecipitation (IP)||12 Antibodies|
|Antigen||Vascular Endothelial Growth Factor A (VEGFA) Antibodies|
|Epitope||AA 147-176, Middle Region Alternatives|
|Conjugate||This VEGF antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-VEGF AntibodyTarget Details VEGF Application Details Handling References for anti-VEGF Antibody (ABIN955508) Images
|Specificity||This antibody detects VEGF-A (Center).|
|Cross-Reactivity (Details)||Species reactivity (tested):Human|
|Purification||Protein A column followed by peptide affinity purification|
|Immunogen||KLH conjugated synthetic peptide between 147-176 amino acids from the Central region of human VEGFA|
Target Details VEGFProduct Details anti-VEGF Antibody Application Details Handling References for anti-VEGF Antibody (ABIN955508) Images back to top
|Alternative Name||VEGF-A (VEGFA Antibody Abstract)|
|Background||This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.Synonyms: VEGF, VEGFA, VPF, Vascular endothelial growth factor A, Vascular permeability factor|
|Research Area||Cytokines, Growth Factors, Receptors, Immunology, Inflammation, Signaling|
Application DetailsProduct Details anti-VEGF Antibody Target Details VEGF Handling References for anti-VEGF Antibody (ABIN955508) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-VEGF Antibody Target Details VEGF Application Details References for anti-VEGF Antibody (ABIN955508) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.|
References for anti-VEGF Antibody (ABIN955508)Product Details anti-VEGF Antibody Target Details VEGF Application Details Handling Images back to top
Shrivastava-Ranjan, Rollin, Spiropoulou: "Andes virus disrupts the endothelial cell barrier by induction of vascular endothelial growth factor and downregulation of VE-cadherin." in: Journal of virology, Vol. 84, Issue 21, pp. 11227-34, 2010 (PubMed).
Yang, Andresen, Yang et al.: "Association of vascular endothelial growth factor -634C/G polymorphism and diabetic retinopathy in type 2 diabetic Han Chinese." in: Experimental biology and medicine (Maywood, N.J.), Vol. 235, Issue 10, pp. 1204-11, 2010 (PubMed).
Kim, Kim, Park et al.: "VEGF polymorphisms in early cervical cancer susceptibility, angiogenesis, and survival." in: Gynecologic oncology, Vol. 119, Issue 2, pp. 232-6, 2010 (PubMed).
Huez, Bornes, Bresson et al.: "New vascular endothelial growth factor isoform generated by internal ribosome entry site-driven CUG translation initiation." in: Molecular endocrinology (Baltimore, Md.), Vol. 15, Issue 12, pp. 2197-210, 2001 (PubMed).
Tee, Jaffe: "A precursor form of vascular endothelial growth factor arises by initiation from an upstream in-frame CUG codon." in: The Biochemical journal, Vol. 359, Issue Pt 1, pp. 219-26, 2001 (PubMed).
ImagesProduct Details anti-VEGF Antibody Target Details VEGF Application Details Handling References for anti-VEGF Antibody (ABIN955508) back to top