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Human VEGFC ELISA Kit for Sandwich ELISA - ABIN411382
Zhao, Sun, Li: Expression and clinical significance of STAT3, P-STAT3, and VEGF-C in small cell lung cancer. in Asian Pacific journal of cancer prevention : APJCP 2012
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Human VEGFC ELISA Kit for Sandwich ELISA - ABIN625369
Yue, Xu, Zhu, Zhang, Liu: Over-expression of nerve growth factor-β in human cholangiocarcinoma QBC939 cells promote tumor progression. in PLoS ONE 2013
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Human VEGFC ELISA Kit for Sandwich ELISA - ABIN414935
You, Bei, Cheng, Cheng: Expression of COX-2 and VEGF-C in cholangiocarcinomas at different clinical and pathological stages. in Genetics and molecular research : GMR 2015
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Mouse (Murine) VEGFC ELISA Kit for Sandwich ELISA - ABIN415601
Zhang, Wang, Gao, Guo, Chen, Wang, Gao, Rao, Chen: Alternatively activated RAW264.7 macrophages enhance tumor lymphangiogenesis in mouse lung adenocarcinoma. in Journal of cellular biochemistry 2009
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Mouse (Murine) VEGFC ELISA Kit for Sandwich ELISA - ABIN365459
Shimizu, Shibata, Shintani, Ishii, Murohara: Therapeutic lymphangiogenesis with implantation of adipose-derived regenerative cells. in Journal of the American Heart Association 2012
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Human VEGFC ELISA Kit for Sandwich ELISA - ABIN365328
Tang, Jiang, Guo, Si, Jiao: Expression and significance of vascular endothelial growth factor A and C in leukemia central nervous system metastasis. in Leukemia research 2013
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Vegfc acts through ERK (show MAPK1 ELISA Kits) to induce sprouting and differentiation of trunk lymphatic progenitors.
data not only reveal a non-canonical function of Mt2 (show MT2 ELISA Kits) in angiogenesis, but also propose Mt2 (show MT2 ELISA Kits) as a novel regulator of vegfc expression.
Vegfc signaling increases mafba (show MAFB ELISA Kits) expression to control downstream transcription
Vegfc is dispensable for facial lymphatic sprouting but not for the complete development of the facial lymphatic network.
In the embryo, phenotypes driven by increased Vegfc are suppressed in the absence of Ccbe1 (show CCBE1 ELISA Kits), and Vegfc-driven sprouting is enhanced by local Ccbe1 (show CCBE1 ELISA Kits) overexpression. Moreover, Vegfc- and Vegfr3 (show FLT4 ELISA Kits)-dependent Erk (show MAPK1 ELISA Kits) signaling is impaired in the absence of Ccbe1 (show CCBE1 ELISA Kits).
Vegfc has an essential role in lymphangiogenesis [review]
The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 (show FLT4 ELISA Kits) signaling in zebrafish.
Vegfc acts in two distinct modes during development: as a paracrine factor secreted from arteries to guide closely associated lymphatic vasculature and as an autocrine factor to drive migratory persistence during angiogenesis.
Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.
Here, we show that vascular endothelial growth factor C (Vegfc), an angiogenic as well as a lymphangiogenic factor, is unexpectedly involved in this process in zebrafish.
VEGF-C and VEGF-C156S genes have roles in the pro-lymphangiogenic growth factor therapy of lymphedema
Transcription of the vascular endothelial growth factor C gene (VEGF-C) and translation of the corresponding protein were significantly up-regulated in swine umbilical vein endothelial cells with classical swine fever virus acute infection.
No difference in bioactivity was detected between porcine relaxin-1 (show RLN1 ELISA Kits) and recombinant human relaxin-2 (show RLN1 ELISA Kits) in either mice or rats.
During progressive ischemia, functional and metabolic benefits of intramyocardial VEGF-C gene transfer were apparent. VEGF-C-induced collateral formation occurred at the site of gene transfer
In multivariate analysis, only serum VEGF-A (show VEGFA ELISA Kits) correlated to diabetes duration, whereas VEGF-C only correlated to HbA1c and fasting blood glucose.
This study reports that human dendritic cells produce VEGF-C, a cytokine with potent pro-lymphangiogenic activity when stimulated with IFN-gamma (show IFNG ELISA Kits)
Association of coexpressed high levels of VEGF-C and active MMP-9 (show MMP9 ELISA Kits) with lymphatic spreading and local invasiveness of Papillary thyroid carcinoma (PTC (show F9 ELISA Kits)) suggests their potential usefulness as predictive biomarkers of aggressive PTC (show F9 ELISA Kits) behavior.
Data show that VEGF-C, VEGF-D (show Figf ELISA Kits), and VEGFR-3 (show FLT4 ELISA Kits) were expressed in a substantial percentage of breast carcinomas.
By treating LECs with VEGF (show VEGFA ELISA Kits)-C156S and analyzing subsequent changes in gene expression, we identified several 'immediate early (show JUN ELISA Kits)' transcription factors that showed a rapid transient upregulation VEGFR-3 (show FLT4 ELISA Kits) stimulation. these results reveal an important and unanticipated role of HOXD10 (show HOXD10 ELISA Kits) in the regulation of VEGFR-3 (show FLT4 ELISA Kits) signaling in lymphatic endothelial cells, and in the control of lymphangiogenesis and permeability.
In colon cancer samples, there was a positive correlation between the expression of integrin alpha4 and VEGF-C. Integrin alpha4 and VEGF-C were significantly associated with the clinicopathological parameters (LMVD, Duke's stage, and lymph node metastasis). patients with high integrin alpha4 or VEGF-C expression had significantly shorter overall survival and tumor-free survival time.
High VEGFC expression is associated with angiogenesis and lymphangiogenesis.
Adiponectin (show ADIPOQ ELISA Kits) promoted VEGF-C expression and secretion in human chondrosarcoma cells.
HuR (show ELAVL1 ELISA Kits) plays important roles in determining malignant aggressiveness and outcome in prostate cancer (PCa (show FLVCR1 ELISA Kits)), especially in androgen-independent PCa (show FLVCR1 ELISA Kits) cells, via the regulation of cell proliferation, migration, and expression of VEGF-A (show VEGFA ELISA Kits), -C, and COX-2 (show COX2 ELISA Kits).
Study showed that VEGF-C levels are high in hypervolemic and low in euvolemic (and hypovolemic) chronic kidney disease patients; serum VEGF-C levels were significantly correlated with bioimpedance spectroscopy measurements
lymphangiogenesis is regulated by two distinct proteolytic mechanisms of ligand activation: one in which VEGFC activation by ADAMTS3 (show Adamts2 ELISA Kits) and CCBE1 (show CCBE1 ELISA Kits) spatially and temporally patterns developing lymphatics, and one in which VEGFD (show Figf ELISA Kits) activation by a distinct proteolytic mechanism may be stimulated during inflammatory lymphatic growth
These results reveal an unexpected role for VEGF-C, a major lymphangiogenic growth factor, in the transition to fetal liver erythropoiesis.
Results suggest that interleukin-6 (IL-6 (show IL6 ELISA Kits)) increases VEGF-C induction and lymphangiogenesis may involve, at least in part, Src (show SRC ELISA Kits)-FAK (show PTK2 ELISA Kits)-STAT3 (show STAT3 ELISA Kits) cascade in lymphatic endothelial cells (LECs).
Data show that heparanase-1 (HPA-1 (show HPSE ELISA Kits)) induced shedding of heparan sulfate chain from syndecan-1 (SDC-1 (show SDC1 ELISA Kits)) facilitated the release of vascular endothelial growth factor C (VEGF-C) from SDC-1 (show SDC1 ELISA Kits)/VEGF-C complex into the medium of hepatocarcinoma cell.
Data show that in the MCF-7 breast cancer cell line, only MT1X metallothioneins (MTs (show NEU2 ELISA Kits)) positively correlated with vascular endothelial growth factor C (VEGFC).
The findings in this study strongly suggest the following: i) that VEGF-C promotes the proliferative activity and migratory ability of mesenchymal stem cell ; and ii) VEGF-C and Tgfb (show TGFB1 ELISA Kits) reciprocally regulate mesenchymal stem cell commitment to differentiation into lymphatic endothelial or osteoblastic phenotypes, respectively.
The authors show that VEGF-C is necessary for perinatal lymphangiogenesis, but required for adult lymphatic vessel maintenance only in the intestine.
MT1-MMP (show MMP14 ELISA Kits) directly cleaves LYVE-1 (show LYVE1 ELISA Kits) on lymphatic endothelial cells to inhibit LYVE-1 (show LYVE1 ELISA Kits)-mediated lymphangiogenic responses and restrains the production of VEGF-C.
HA increases lymphangiogenesis in renal fibrosis model and also stimulates vascular endothelial cell growth factor (show FGF1 ELISA Kits)-C production from macrophages through Toll-like receptor 4 (show TLR4 ELISA Kits)-dependent signal pathway
Results showed that the VEGF-C/VEGFR-3 (show FLT4 ELISA Kits) system underlies the protective effect of ischemic preconditioning against forebrain ischemia in the mouse hippocampus
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.
vascular endothelial growth factor C
, vascular endothelial growth factor c
, FLT4 ligand DHM
, vascular endothelial growth factor-related protein
, flt4 ligand
, vascular endothelial growth factor C isoform 129
, vascular endothelial growth factor C isoform 184