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Human VEGFR2 Protein expressed in Insect Cells - ABIN809790
Hiley, Chard, Gangeswaran, Tysome, Briat, Lemoine, Wang: Vascular endothelial growth factor A promotes vaccinia virus entry into host cells via activation of the Akt pathway. in Journal of virology 2013
These results indicate that VEGF-C (show VEGFC Proteins)-induced MSC (show MSC Proteins) osteogenesis is mediated through VEGFR2 and VEGFR3 (show FLT4 Proteins), and followed the activation of the ERK (show MAPK1 Proteins)/RUNX2 (show RUNX2 Proteins) signaling pathway.
These results revealed that vascular sprouting and permeability are both controlled through the VEGFR2-TSAd-c-Src signaling pathway in a subset of tissues, which may be useful in developing strategies to control tissue-specific pathological angiogenesis.
Data show that editing of genomic VEGFR2 locus using rAAV1-mediated CRISPR/Cas9 abrogates angiogenesis in the mouse models of oxygen-induced retinopathy and laser-induced choroid neovascularization.
Our study demonstrates that Prox1 (show C16orf35 Proteins)-GFP/Flk1::myr-mCherry mice are a useful model for studying coordinated hemangiogenic and lymphangiogenic responses
Endoglin (show ENG Proteins) prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling
CLEC14A (show CLEC14A Proteins) acts in vascular homeostasis by fine-tuning VEGFR-2 and VEGFR-3 (show FLT4 Proteins) signaling in endothelial cells
The elevated soluble VEGFR-2 that was found in the aortas of apoE (show APOE Proteins)(-/-) mice with atherosclerosis binds to and diminishes the activity of VEGF-C (show VEGFC Proteins).
Data show that Leishmania major infection initiates enhanced vascular endothelial growth factor-A (show VEGFA Proteins)/VEGFR-2 signaling and suggest that VEGFR-2-dependent lymphangiogenesis is a mechanism that restricts tissue inflammation in leishmaniasis.
VEGFR3 (show FLT4 Proteins) limits VEGFR2 expression and VEGF (show VEGFA Proteins)/VEGFR2 pathway activity in quiescent and angiogenic blood vascular endothelial cells, thereby preventing excessive vascular permeability.
fetal mouse lung mesenchymal cells express Vegfr2 and respond to VEGF-A (show VEGFA Proteins) stimulation.
Deletion of microRNA miR (show MLXIP Proteins)-150 increased the retinal pathological angiogenesis in high-fat-diet (HFD) induced type 2 diabetic mice, which was in part through vascular endothelial growth factor receptor 2 (VEGFR2).
this study found no difference in VEGFR2 expression in infantile hemangiomas from the study and control group
MiRNA199a-3p suppresses tumor growth, migration, invasion and angiogenesis in hepatocellular carcinoma by targeting VEGFA (show VEGFA Proteins), VEGFR1 (show FLT1 Proteins), VEGFR2, HGF (show HGF Proteins) and MMP2 (show MMP2 Proteins)
Leptin (show LEP Proteins)-induced transphosphorylation of vascular endothelial growth factor receptor (show RYK Proteins) increases Notch (show NOTCH1 Proteins) and stimulates endothelial cell angiogenic transformation
The study aimed to assess the usefulness of the determination of cytokines: IL-8 (show IL8 Proteins), VEGF (show VEGFA Proteins) and its soluble receptors: VEGF (show VEGFA Proteins)-R1, VEGF (show VEGFA Proteins)-R2 in patients with endometrial cancer. The concentrations of IL-8 (show IL8 Proteins) were an independent prognostic factor in the assessment of overall survival in patients with type I endometrial cancer, while the concentrations of VEGFR2 in those with type II.
High VEGFR expression is associated with melanoma.
OGN (show OGN Proteins) plays a critical role in negatively regulating ischaemia-induced angiogenesis by inhibiting VEGF (show VEGFA Proteins)-VEGFR2 signalling and thereby attenuating endothelial cells tube formation, proliferation, and migration.
Cryptotanshinone potently inhibits VEGF-induced angiogenesis by suppressing VEGFR2 activation and its downstream Src/FAK and ERK1/2 signaling pathways in HUVECs.
The model showed agreement at several key nodes, involving scaffolding proteins Gab1, Gab2 (show GAB2 Proteins) and their complexes with Shp2 (show PTPN11 Proteins). VEGFR2 recruitment of Gab1 is greater in magnitude, slower, and more sustained than that of Gab2 (show GAB2 Proteins). As Gab2 (show GAB2 Proteins) binds VEGFR2 complexes more transiently than Gab1, VEGFR2 complexes can recycle and continue to participate in other signaling pathways.
TRIM28 (show TRIM28 Proteins) acts as a central factor in controlling endothelial inflammatory responses and angiogenic activities by retaining expression of TNFR-1 (show TNFRSF1A Proteins) and -2 and VEGF receptor 2 in endothelial cells
The results suggest that Necl-4 (show CADM4 Proteins) enhances VEGF (show VEGFA Proteins)-induced activation of PLCgamma-c-Raf (show RAF1 Proteins)-MEK (show MAP2K1 Proteins)-ERK (show EPHB2 Proteins) pathway without affecting the phosphorylation and internalization of VEGFR2.
Here we demonstrate that VEGF (show VEGFA Proteins)-165 mediates MSC (show MSC Proteins) differentiation into ECs via VEGFR-2-dependent induction of Sox18 (show SOX18 Proteins), which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype
NOS stimulation via PI3K, calpain proteases, and SIRT1 (show SIRT1 Proteins)-dependent deacetylation downstream from VEGFR2 activation contributes to these vasodilator responses.
we analyzed the expression and cellular distribution of Flt-1(VEGFR-1 (show FLT1 Proteins)) and Flk-1 (KDR/VEGFR-2)in newborn piglet brain
expression of FLK1, CD146 (show MCAM Proteins) and microvessel density of angiogenesis at the first week of reperfused acute myocardial infarction.
VEGF (show VEGFA Proteins) supplementation at the late embryonic developmental stage might improve the developmental potential of both IVF (show SCN5A Proteins) and somatic nuclear transfer preimplantation porcine embryos through its receptors.
The VEGFR2 mRNA was only upregulated in early glomerulogenesis, suggesting that VEGFR2 is important for the vascular growth.
increased placental expression of the VEGF receptor (show FLT1 Proteins) system is associated with increased placental vascular density observed with the advancement of gestation in the pig
VEGF ligand-receptor system may play an important role in the development and maintenance of the corpus luteum in pigs.
VEGF (show VEGFA Proteins)/Flk-1/Flt-1 (show FLT1 Proteins) system is activated during myocardial ischemia reperfusion injury.
Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (show VEGFA Proteins), pro-MMP-9 (show MMP9 Proteins), MMP-2 (show MMP2 Proteins), VEGFR-1 (show FLT1 Proteins), VEGFR-2, and TIMP-1 (show TIMP1 Proteins), which may contribute to the development of venous stenosis.
data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.
endothelial cells exposed to TGF-beta1 (show TGFB1 Proteins) lose both tip and stalk cell identity, possibly mediated by loss of VEGFR2 signaling.
These results suggest that non-dominant follicles maintain a greater concentration of the mRNA expression of both membrane and soluble VEGF receptors; but follicular dominance is related to a reduction in the mRNA expression of sVEGFR1 and sVEGFR2.
Data suggest that galectin-1 (show LGALS1 Proteins) and VEGFR-2 are expressed at mid-luteal stages in luteal cells of corpus luteum; galectin-1 (show LGALS1 Proteins) binds directly to asparagine-linked glycans (N-glycans) on VEGFR-2 in luteal cells.
MMP-1 (show MMP1 Proteins) promotes VEGFR2 expression and proliferation of endothelial cells through stimulation of PAR-1 (show F2R Proteins) and activation of NF-kappaB (show NFKB1 Proteins)
Vascular endothelial growth factor receptor-2 activates ADP-ribosylation factor 1 (show ARF1 Proteins) to promote endothelial nitric-oxide synthase (show NOS3 Proteins) activation and nitric oxide release from endothelial cells
VEGFR2 mRNA expression was higher at the mid and late luteal stages than at the early I and early II luteal stages, and VEGFR2 protein was higher at the mid and late luteal stages than at estrus (P<0.05)
Alterations in the expression of VEGF-A (show VEGFA Proteins) and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt (show AKT1 Proteins) and endothelial nitric-oxide synthase (eNOS (show NOS3 Proteins))
Placenta growth factor (show PGF Proteins) expression is regulated by both VEGF (show VEGFA Proteins) and hyperglycaemia via VEGFR-2.
Antenatal intratracheal VEGF (show VEGFA Proteins) administration was associated with an increase in Flk-1 immunoreactivity.
Intronic Flk1 genetic enhancer element directs arterial-specific expression via RBPJ (show RBPJ Proteins)-mediated venous repression.
Ca(2 (show CA2 Proteins)+) oscillations depended upon VEGF receptor-2 (Vegfr2) and Vegfr3 (show FLT4 Proteins) in endothelial cells budding from the dorsal aorta (DA) and posterior cardinal (show CARD8 Proteins) vein, respectively.
Methylglyoxal acts on smaller blood vessels in zebrafish via the VEGF receptor (show FLT1 Proteins) signaling cascade, thereby describing a new mechanism that can explain vascular complications under hyperglycemia and elevated MG concentrations.
methylation of Lys (show LYZ Proteins)(1041) promotes the activation of VEGFR-2 and that similar posttranslational modification could also regulate the activity of other receptor tyrosine kinases.
Perturbation of the HSP70 (show HSPA1A Proteins)-HSP90 (show HSP90 Proteins) heat-shock protein axis stimulates degradation of endothelial VEGFR2.
Data indicate that the increase in FLT1/sFLT1 (show FLT1 Proteins) protein levels upon miR-10 (show LILRB2 Proteins) knockdown inhibited the angiogenic behavior of endothelial cells largely by antagonizing vascular endothelial growth factor receptor 2 signaling: [miR10 (show LILRB2 Proteins)]
Early Flk1 expression may be induced by cooperative interactions between Gata (show GATA4 Proteins), Tcf (show HNF4A Proteins)/Lef, Cdx (show CDX1 Proteins) and ER71/Etv2 (show ETV2 Proteins) under the control of Bmp, Wnt (show WNT2 Proteins) and Fgf signaling.
Using 2 distinct pharmacologic VEGFR2 inhibitors the study shows that rap1b (show RAP1A Proteins) and VEGFR2 act additively to control angiogenesis in vivo.
Data show that flk1 is not required for proper vasculogenesis and hematopoiesis in zebrafish embryos; however, the disruption of flk1 impairs the formation or function of vessels generated by sprouting angiogenesis
flk1 is a direct target of FoxH1 (show FOXH1 Proteins); FoxH1 (show FOXH1 Proteins) is involved in vessel formation in zebrafish.
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
vascular endothelial growth factor receptor 2
, VEGF receptor-2
, fetal liver kinase 1
, kinase NYK
, protein-tyrosine kinase receptor flk-1
, soluble vascular endothelial growth factor receptor 2
, vascular endothelial growth factor receptor- 2
, vascular endothelial growth factor receptor-2
, vascular endothelial growth factor receptor-3
, FLK1 kinase insert domain receptor (VEGF receptor 2)
, FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2)
, kinase insert domain protein receptor
, fetal liver kinase-1
, protein-tyrosine kinase receptor Flk-1
, soluble VEGFR2
, tyrosine kinase growth factor receptor
, flk-1 type VEGF receptor
, flk-1 receptor
, protein-tyrosine kinase
, tyrosine kinase receptor
, VEGF receptor-2/Flk-1
, VEGFR-2 homolog B
, fetal liver kinase 1b
, kinase insert domain receptor (a type III receptor tyrosine kinase), b
, kinase insert domain receptor-B
, protein-tyrosine kinase receptor flk-1b
, vascular endothelial growth factor receptor 2 homolog B
, kinase insert domain receptor-A
, kinase insert domain receptor-like
, vascular endothelial growth factor receptor 4
, vascular endothelial growth factor receptor kdr-like
, vascular endothelial growth factor receptor type 2