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Browse our VEGFR2 Proteins (KDR)

Full name:
Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) Proteins (KDR)
On www.antibodies-online.com are 54 Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) Proteins from 17 different suppliers available. Additionally we are shipping VEGFR2 Antibodies (654) and VEGFR2 Kits (81) and many more products for this protein. A total of 814 VEGFR2 products are currently listed.
Synonyms:
6130401C07, CD309, fk52c05, flk, flk-1, FLK/KDR, flk1, flk1b, kdr, kdra, kdrb, Krd-1, Ly73, si:busm1-205d10.1, si:ch211-254j6.1, si:ch211-278f21.4, sVEGFR-2, VEGFR, Vegfr-2, vegfr2, vegfr4, vegr2, wu:fc31a09, wu:fk52c05
list all proteins Gene Name GeneID UniProt
KDR 16542  
KDR 25589 O08775
KDR 3791 P35968

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VEGFR2 Proteins (KDR) by Origin

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Top referenced VEGFR2 Proteins

  1. Human VEGFR2 Protein expressed in HEK-293 - ABIN2666871 : Albuquerque, Hayashi, Cho, Kleinman, Dridi, Takeda, Baffi, Yamada, Kaneko, Green, Chappell, Wilting, Weich, Yamagami, Amano, Mizuki, Alexander, Peterson, Brekken, Hirashima, Capoor, Usui, Ambati et al.: Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. ... in Nature medicine 2009 (PubMed)
    Show all 7 references for ABIN2666871

  2. Mouse (Murine) VEGFR2 Protein expressed in CHO Cells - ABIN2666873 : DiSalvo, Bayne, Conn, Kwok, Trivedi, Soderman, Palisi, Sullivan, Thomas: Purification and characterization of a naturally occurring vascular endothelial growth factor.placenta growth factor heterodimer. in The Journal of biological chemistry 1995 (PubMed)
    Show all 7 references for ABIN2666873

  3. Rat (Rattus) VEGFR2 Protein expressed in Human Cells - ABIN2009185 : McTigue, Wickersham, Pinko, Showalter, Parast, Tempczyk-Russell, Gehring, Mroczkowski, Kan, Villafranca, Appelt: Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis. in Structure (London, England : 1993) 1999 (PubMed)
    Show all 4 references for ABIN2009185

  4. Human VEGFR2 Protein expressed in Baculovirus infected Insect Cells - ABIN2001898 : Terman, Dougher-Vermazen, Carrion, Dimitrov, Armellino, Gospodarowicz, Böhlen: Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. in Biochemical and biophysical research communications 1992 (PubMed)
    Show all 4 references for ABIN2001898

  5. Mouse (Murine) VEGFR2 Protein expressed in Human Cells - ABIN2008496 : Patterson, Perrella, Hsieh, Yoshizumi, Lee, Haber: Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor. in The Journal of biological chemistry 1995 (PubMed)
    Show all 4 references for ABIN2008496

  6. Mouse (Murine) VEGFR2 Protein expressed in Human Cells - ABIN2008494 : Holmqvist, Cross, Rolny, Hägerkvist, Rahimi, Matsumoto, Claesson-Welsh, Welsh: The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration. in The Journal of biological chemistry 2004 (PubMed)
    Show all 4 references for ABIN2008494

  7. Human VEGFR2 Protein expressed in Insect Cells - ABIN809790 : Hiley, Chard, Gangeswaran, Tysome, Briat, Lemoine, Wang: Vascular endothelial growth factor A promotes vaccinia virus entry into host cells via activation of the Akt pathway. in Journal of virology 2013 (PubMed)

More Proteins for VEGFR2 Interaction Partners

Mouse (Murine) Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) interaction partners

  1. Data suggest that expression of Notch-1 (show NOTCH1 Proteins) receptor in endothelial progenitor cells (EPC (show TCF21 Proteins)) in bone marrow is up-regulated in diabetic angiopathy (DA); signaling in EPC (show TCF21 Proteins) via Notch-1 (show NOTCH1 Proteins) receptor and VEGFA (show VEGFA Proteins)/VEGFR2 appears to be altered in DA.

  2. Collectively, these data suggest that VEGF (show VEGFA Proteins)/VEGFR2 signaling regulates germ cell proliferation and promotes testicular regeneration via direct action on germ cells and the enhancement of vascularization.

  3. administration of 0.3 IU/mL FSH (show BRD2 Proteins) during ovarian cryopreservation by vitrification can maintain ovarian survival during ovarian vitrification and increases the blood supply with avascular transplantation via upregulation of Cx43 (show GJA1 Proteins), Cx37 (show GJA4 Proteins), and VEGF (show VEGFA Proteins)/VEGFR2

  4. The data provide new insights for the chaperone function of PDCL3 (show PDCL3 Proteins) in angiogenesis and the roles of hypoxia and N-terminal methionine acetylation in PDCL3 (show PDCL3 Proteins) expression and its effect on VEGFR-2.

  5. VEGFA (show VEGFA Proteins)-induced vascular leakage depends on signaling initiated via the VEGFR2 phosphosite Y949. Abolished Y949 signaling in the mutant Vegfr2(Y949F/Y949F) leads to VEGFA (show VEGFA Proteins)-resistant endothelial adherens junctions.

  6. These findings together demonstrate the essential role of KDM4A (show KDM4A Proteins) and KDM4C (show KDM4C Proteins) in orchestrating mESC differentiation to endothelial cells through the activation of Flk1 and VE-cadherin (show CDH5 Proteins) promoters, respectively

  7. VEGFA (show VEGFA Proteins)/VEGFR2 signaling may be essential for podocytes in a normal state.

  8. Thus, (131)I-anti-VEGFR2 cFab (show CFB Proteins) has the potential to be used for molecularly targeted treatment of hepatocellular carcinoma overexpressing VEGFR2.

  9. tumors in stressed animals demonstrated markedly enhanced expression of VEGFR-2 and L1CAM (show L1CAM Proteins) mRNA as well as pERK (show EIF2AK3 Proteins), MMP-2 (show MMP2 Proteins) and MMP-9 (show MMP9 Proteins) protein expression.

  10. These results suggest that VEGFR2-mediated Muller cell survival is required for the viability of retinal neurons in diabetes.

Human Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) interaction partners

  1. VEGFR2, the main target of VEGFA (show VEGFA Proteins)-induced angiogenesis, was underexpressed in BA, and VEGFA (show VEGFA Proteins) was decreased in most BA patients.

  2. High expression of VEGFR2 is associated with astrocytomas.

  3. High VEGFR2 expression is associated with Gastric Adenocarcinoma.

  4. Sorafenib controls the growth of endometriotic lesions in vitro and in vivo by inhibiting MAPK (show MAPK1 Proteins)/VEGFR signaling.

  5. Negative for VEGF (show VEGFA Proteins)/VEGFR2.

  6. inhibitory effect of RSV on the HIF-1alpha (show HIF1A Proteins)/VEGF (show VEGFA Proteins)/VEGFR2 signaling axis is mediated, at least in part, through SIRT1 (show SIRT1 Proteins)

  7. High expression of VEGFR2 (KDR) is significantly associated with decreased patients' survival

  8. IL-8 (show IL8 Proteins) rs4073 and VEGFR-2 rs2071559 genotypes may represent important molecular determinants to modulate final outcomes in neovascular age-related macular degeneration patients.

  9. Report KDR genetic alterations in angiosarcomas.

  10. The properties of VEGFR2 and c-telopeptide collagen observed in this study inform the design of future combination antiangiogenic therapy trials.

Pig (Porcine) Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) interaction partners

  1. Here we demonstrate that VEGF (show VEGFA Proteins)-165 mediates MSC (show MSC Proteins) differentiation into ECs via VEGFR-2-dependent induction of Sox18 (show SOX18 Proteins), which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype

  2. NOS stimulation via PI3K, calpain proteases, and SIRT1 (show SIRT1 Proteins)-dependent deacetylation downstream from VEGFR2 activation contributes to these vasodilator responses.

  3. we analyzed the expression and cellular distribution of Flt-1(VEGFR-1 (show FLT1 Proteins)) and Flk-1 (KDR/VEGFR-2)in newborn piglet brain

  4. expression of FLK1, CD146 (show MCAM Proteins) and microvessel density of angiogenesis at the first week of reperfused acute myocardial infarction.

  5. VEGF (show VEGFA Proteins) supplementation at the late embryonic developmental stage might improve the developmental potential of both IVF (show SCN5A Proteins) and somatic nuclear transfer preimplantation porcine embryos through its receptors.

  6. The VEGFR2 mRNA was only upregulated in early glomerulogenesis, suggesting that VEGFR2 is important for the vascular growth.

  7. increased placental expression of the VEGF receptor (show FLT1 Proteins) system is associated with increased placental vascular density observed with the advancement of gestation in the pig

  8. VEGF ligand-receptor system may play an important role in the development and maintenance of the corpus luteum in pigs.

  9. VEGF (show VEGFA Proteins)/Flk-1/Flt-1 (show FLT1 Proteins) system is activated during myocardial ischemia reperfusion injury.

  10. Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (show VEGFA Proteins), pro-MMP-9 (show MMP9 Proteins), MMP-2 (show MMP2 Proteins), VEGFR-1 (show FLT1 Proteins), VEGFR-2, and TIMP-1 (show TIMP1 Proteins), which may contribute to the development of venous stenosis.

Cow (Bovine) Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) interaction partners

  1. Data suggest that galectin-1 (show LGALS1 Proteins) and VEGFR-2 are expressed at mid-luteal stages in luteal cells of corpus luteum; galectin-1 (show LGALS1 Proteins) binds directly to asparagine-linked glycans (N-glycans) on VEGFR-2 in luteal cells.

  2. MMP-1 (show MMP1 Proteins) promotes VEGFR2 expression and proliferation of endothelial cells through stimulation of PAR-1 (show F2R Proteins) and activation of NF-kappaB (show NFKB1 Proteins)

  3. Vascular endothelial growth factor receptor-2 activates ADP-ribosylation factor 1 (show ARF1 Proteins) to promote endothelial nitric-oxide synthase (show NOS3 Proteins) activation and nitric oxide release from endothelial cells

  4. VEGFR2 mRNA expression was higher at the mid and late luteal stages than at the early I and early II luteal stages, and VEGFR2 protein was higher at the mid and late luteal stages than at estrus (P<0.05)

  5. Alterations in the expression of VEGF-A (show VEGFA Proteins) and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

  6. involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt (show AKT1 Proteins) and endothelial nitric-oxide synthase (eNOS (show NOS3 Proteins))

  7. Placenta growth factor (show PGF Proteins) expression is regulated by both VEGF (show VEGFA Proteins) and hyperglycaemia via VEGFR-2.

  8. ROS (show ROS1 Proteins) induce expression not only of VEGF (show VEGFA Proteins) but also of VEGFR2. VEGFR2 increase by ROS (show ROS1 Proteins) is mainly driven through a NF-kappaB (show NFKB1 Proteins)-dependent pathway.

  9. By regulating VEGFR2 expression and activation, PKC-epsilon (show PRKCE Proteins) expression is critical for activation of Akt (show AKT1 Proteins) and eNOS (show NOS3 Proteins) by VEGF (show VEGFA Proteins) and contributes to VEGF (show VEGFA Proteins)-stimulated Erk (show MAPK1 Proteins) activation, whereas PKC-alpha (show PKCa Proteins) has opposite effects.

Rabbit Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) interaction partners

  1. Antenatal intratracheal VEGF (show VEGFA Proteins) administration was associated with an increase in Flk-1 immunoreactivity.

Zebrafish Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) interaction partners

  1. Ca(2 (show CA2 Proteins)+) oscillations depended upon VEGF receptor-2 (Vegfr2) and Vegfr3 (show FLT4 Proteins) in endothelial cells budding from the dorsal aorta (DA) and posterior cardinal (show CARD8 Proteins) vein, respectively.

  2. Methylglyoxal acts on smaller blood vessels in zebrafish via the VEGF receptor (show FLT1 Proteins) signaling cascade, thereby describing a new mechanism that can explain vascular complications under hyperglycemia and elevated MG concentrations.

  3. methylation of Lys (show LYZ Proteins)(1041) promotes the activation of VEGFR-2 and that similar posttranslational modification could also regulate the activity of other receptor tyrosine kinases.

  4. Perturbation of the HSP70 (show HSPA1A Proteins)-HSP90 (show HSP90 Proteins) heat-shock protein axis stimulates degradation of endothelial VEGFR2.

  5. Data indicate that the increase in FLT1/sFLT1 (show FLT1 Proteins) protein levels upon miR-10 (show LILRB2 Proteins) knockdown inhibited the angiogenic behavior of endothelial cells largely by antagonizing vascular endothelial growth factor receptor 2 signaling: [miR10 (show LILRB2 Proteins)]

  6. Early Flk1 expression may be induced by cooperative interactions between Gata (show GATA4 Proteins), Tcf (show HNF4A Proteins)/Lef, Cdx (show CDX1 Proteins) and ER71/Etv2 (show ETV2 Proteins) under the control of Bmp, Wnt (show WNT2 Proteins) and Fgf signaling.

  7. Using 2 distinct pharmacologic VEGFR2 inhibitors the study shows that rap1b (show RAP1A Proteins) and VEGFR2 act additively to control angiogenesis in vivo.

  8. Data show that flk1 is not required for proper vasculogenesis and hematopoiesis in zebrafish embryos; however, the disruption of flk1 impairs the formation or function of vessels generated by sprouting angiogenesis

  9. flk1 is a direct target of FoxH1 (show FOXH1 Proteins); FoxH1 (show FOXH1 Proteins) is involved in vessel formation in zebrafish.

  10. In the zebrafish, duplicated VegfA (show VEGFA Proteins) and multiple type III RTKs mediate vascular development.

VEGFR2 (KDR) Protein Profile

Protein Summary

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.

Alternative names and synonyms associated with VEGFR2 (KDR)

  • vascular endothelial growth factor receptor 2 (vegfr-2)
  • kinase insert domain protein receptor (Kdr)
  • kinase insert domain receptor (Kdr)
  • kinase insert domain receptor (a type III receptor tyrosine kinase) (KDR)
  • kinase insert domain receptor (a type III receptor tyrosine kinase) (Kdr)
  • kinase insert domain receptor (a type III receptor tyrosine kinase) (kdr)
  • kinase insert domain receptor like (kdrl)
  • vascular endothelial growth factor receptor-2 (KDR)
  • 6130401C07 protein
  • CD309 protein
  • fk52c05 protein
  • flk protein
  • flk-1 protein
  • FLK/KDR protein
  • flk1 protein
  • flk1b protein
  • kdr protein
  • kdra protein
  • kdrb protein
  • Krd-1 protein
  • Ly73 protein
  • si:busm1-205d10.1 protein
  • si:ch211-254j6.1 protein
  • si:ch211-278f21.4 protein
  • sVEGFR-2 protein
  • VEGFR protein
  • Vegfr-2 protein
  • vegfr2 protein
  • vegfr4 protein
  • vegr2 protein
  • wu:fc31a09 protein
  • wu:fk52c05 protein

Protein level used designations for KDR

vascular endothelial growth factor receptor 2 , VEGF receptor-2 , fetal liver kinase 1 , kinase NYK , protein-tyrosine kinase receptor flk-1 , soluble vascular endothelial growth factor receptor 2 , vascular endothelial growth factor receptor- 2 , vascular endothelial growth factor receptor-2 , vascular endothelial growth factor receptor-3 , FLK-1 , FLK1 kinase insert domain receptor (VEGF receptor 2) , FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2) , kinase insert domain protein receptor , fetal liver kinase-1 , protein-tyrosine kinase receptor Flk-1 , soluble VEGFR2 , tyrosine kinase growth factor receptor , flk-1 type VEGF receptor , VEGFR2 , flk-1 receptor , protein-tyrosine kinase , tyrosine kinase receptor , VEGF receptor-2/Flk-1 , FLK-1b , VEGFR-2 homolog B , fetal liver kinase 1b , kinase insert domain receptor (a type III receptor tyrosine kinase), b , kinase insert domain receptor-B , protein-tyrosine kinase receptor flk-1b , vascular endothelial growth factor receptor 2 homolog B , VEGFR-4 , kinase insert domain receptor-A , kinase insert domain receptor-like , vascular endothelial growth factor receptor 4 , vascular endothelial growth factor receptor kdr-like , vascular endothelial growth factor receptor type 2

GENE ID SPECIES
100136647 Oncorhynchus mykiss
16542 Mus musculus
25589 Rattus norvegicus
3791 Homo sapiens
397311 Sus scrofa
482154 Canis lupus familiaris
395323 Gallus gallus
407170 Bos taurus
100726761 Cavia porcellus
100008607 Oryctolagus cuniculus
554230 Danio rerio
796537 Danio rerio
443087 Ovis aries
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