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Lpd (show ACSBG1 Proteins) regulates mesenchymal neu (show AKT1 Proteins)ral crest cell migration cell autonomously in Xeno (show ACSBG1 Proteins)pus laevis via the Scar/WAVE complex.
this sudy identifies Wave1 as a maternal reprogramming factor that also has a necessary role in gene activation in development.
The rapid growth of roots in the light requires a functional ARP2/3-SCAR complex. Light is essential for stabilizing the SCAR complex in the plasma membrane, which is necessary for maintaining longitudinally organized F-actin to sustain rapid root growth.
we propose that WASF1 status defines a subtype of androgen deprivation therapy -resistant prostate cancer patients
a role for ARF6 in linking EGF-receptor signaling to Rac1 recruitment and activation at the plasma membrane to promote breast cancer cell directed migration
A decrease in amounts of WASF1 mRNA was also observed in human Alzheimer's disease brains, suggesting clinical relevance of the negative feedback circuit involved in homeostatic regulation of Abeta (show APP Proteins) production
D620N mutation in VPS35 (show vps35 Proteins) restricts WASH complex recruitment to endosomes, and reveals a novel role for the WASH complex in autophagosome formation.
WAVE1 has unique activities independent of Arp2 (show ACTR2 Proteins)/3 complex that can govern both the growth rates and architectures of actin filament networks. Elongation inhibitory effects of WAVE1 were mapped to its WH2 ("V") domain.
The WAVE complex is the main activator of the Arp2/3 complex for actin filament nucleation and assembly in the lamellipodia of moving cells.
WAVE1 might promote the proliferative and invasive malignant behaviors through the activation of the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) and p38MAPK (show MAPK14 Proteins) signaling pathways in epithelial ovarian cancer.
Scar/WAVE regulatory complex and N-WASP (show WASL Proteins) play opposing roles in 3D epithelial cell migration
Study finds that WAVE1 overexpression is associated with an unfavorable prognosis. WAVE1 is an independent prognostic factor for EOC, which suggests that it is a novel and crucial predictor for EOC metastasis.
mDia1 and WAVE2 (show WASF2 Proteins) are important Src (show SRC Proteins) homology 3 domain partners of IRSp53 (show BAIAP2 Proteins) in forming filopodia.
Signaling through WAVE-1 plays a critical role in establishing normal synaptic architecture in the rodent hippocampus.
Lpd (show ACSBG1 Proteins) directly binds active Rac (show AKT1 Proteins), which regulates a direct interaction between Lpd (show ACSBG1 Proteins) and the Scar/WAVE complex
An unanticipated role for WAVE1 as a critical modulator of the innate immune response to severe bacterial infections.
Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex
In cell migration WAVE1 is essential in MMP-dependent migration in extracellular matrix and WAVE2 (show WASF2 Proteins) is for leading edge extension for directed migration in general.
Nap1 mutant phenotypes define the crucial roles of Nap1/WAVE-mediated actin regulation in tissue organization and establishment of the body plan of the mammalian embryo.
data suggest that phosphorylation/dephosphorylation of WAVE1 in neurons has an important role in the formation of the filamentous actin cytoskeleton, and thus in the regulation of dendritic spine morphology
NESH (Abi-3 (show ABI3 Proteins)), like Abi-1 (show ABI1 Proteins) and Abi-2, is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl (show ABL1 Proteins).
WAVE-1 signaling complexes control aspects of neuronal morphogenesis and synaptic plasticity.
Major role for Scar/WAVE-1 in mediating platelet cytoskeletal reorganization and aggregate formation downstream of activation by GPVI (show GP6 Proteins).
Data show that WAVE1 sequestration to the nucleus is required during fertilization, and is an actin-independent event that relies on dynamic microtubules but not nuclear pores.
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
WASP family protein member 1
, homology of dictyostelium scar 1
, protein WAVE-1
, verprolin homology domain-containing protein 1
, wiskott-Aldrich syndrome protein family member 1
, WASP family 1