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p63alpha protein up-regulates heat shock protein 70 (show HSP70 ELISA Kits) expression via E2F1 transcription factor (show E2F1 ELISA Kits) 1 (show HNF1A ELISA Kits), promoting Wasf3/Wave3/MMP9 (show MMP9 ELISA Kits) signaling and bladder cancer invasion
we show that WASF3 is present in the HER2 (show ERBB2 ELISA Kits) immunocomplex and suppression of WASF3 function leads to suppression of invasion even in the presence of HER2 (show ERBB2 ELISA Kits) expression.The engagement of WASF3 with the HER2 (show ERBB2 ELISA Kits)/HER3 (show ERBB3 ELISA Kits) complex facilitates its phospho-activation and transcriptional upregulation, which is facilitated by HER2 (show ERBB2 ELISA Kits)/HER3 (show ERBB3 ELISA Kits) activation of JAK (show JAK3 ELISA Kits)/STAT (show STAT1 ELISA Kits) signaling.
we show that stapled peptides targeting the interface between NCKAP1 (show NCKAP1 ELISA Kits) and CYFIP1 (show CYFIP1 ELISA Kits) destabilize the WASF3 complex... thereby suppressing invasion and metastasis of breast cancer cells.
It was concluded that WAVE3 may represent a new adverse prognostic factor for patients with ICC.
studies provide a deeper understanding of the critical role for WASF3 in facilitating increased invasion potential in cancer cells expressing mutant RAS and supports the idea that targeting WASF3 in metastatic cells overexpressing RAS may be used to suppress invasion and metastasis
Results implicate a contributory role of WAVE1 (show WASF1 ELISA Kits) and -3 to the metastatic phenotype of PC-3 (show PCSK1 ELISA Kits) cells through their interaction with the ARP2 (show ACTR2 ELISA Kits)/3 complex.
stabilization of WASF3 function occurs through its interaction with ATAD3A (show ATAD3A ELISA Kits) and GRP78 (show HSPA5 ELISA Kits), which may provide a bridge between the ER and mitochondria, allowing communication between the two organelles
We show that WAVE3-mediated modulation of NFkappaB (show NFKB1 ELISA Kits) is required for invadopodia formation as well as MMP9 (show MMP9 ELISA Kits) expression and activity that are needed for cancer cells to degrade the ECM (show MMRN1 ELISA Kits)
WAVE3 is pivotal in controlling oncogenic phenotypes of human hepatocellular carcinoma cells.
WAVE3 promotes epithelial-mesenchymal transition of gastric cancer through upregulation of Snail (show SNAI1 ELISA Kits).
WAVE3 transcript is mainly expressed in the nervous system and, like all the members of the WASP gene family, WAVE3 is a key element in actin polymerization and cytoskeleton organization.
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.
wiskott-Aldrich syndrome protein family member 3
, WASP family Verprolin-homologous protein 3
, WASP family protein member 3
, protein WAVE-3
, verprolin homology domain-containing protein 3