Browse our WASL Proteins (WASL)

Full name:
Wiskott-Aldrich Syndrome-Like Proteins (WASL)
On are 0 Wiskott-Aldrich Syndrome-Like (WASL) Proteins from different suppliers available. A total of 0 WASL products are currently listed.
2900021I12Rik, 3110031I02Rik, IMD2, N-WASP, NWASP, SCNX, THC, THC1, TRS4, U42471, WASL, Wasp, zgc:55478, zgc:77237
list all proteins Gene Name GeneID UniProt
Human WASL WASL 7454 P42768
Rat WASL WASL 317371  
Mouse WASL WASL 22376 P70315

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More Proteins for WASL Interaction Partners

Human Wiskott-Aldrich Syndrome-Like (WASL) interaction partners

  1. Authors show that knock-down of WASp or expression of Y102F mutant of WASp decreases colony formation and in vivo tumor growth. Results show that WASp is a novel substrate of ALK and has a critical role in regulating invasiveness and oncogenesis of ALCL.

  2. this study describes an Iranian boy with Wiskott-Aldrich syndrome with a novel WASP mutation

  3. The inducible recruitment of WASp to the TCR-CD3 (show CD3 Proteins) complex is partially dependent of tyrosine phosphorylation of Cd3e (show CD3E Proteins).

  4. This suggests that TOCA1 binding to Cdc42 is an early step in the Cdc42-dependent pathways that govern actin dynamics, and the differential binding affinities of the effectors facilitate a handover from TOCA1 to N-WASP, which can then drive recruitment of the actin-modifying machinery.

  5. the Cdc42 (show CDC42 Proteins)/Nwasp/stress fibers/YAP (show YAP1 Proteins) signal pathway may potentially play an important role in regulating podocyte apoptosis. Maintaining necessary Cdc42 (show CDC42 Proteins) would be one potent way to prevent proteinuria kidney diseases.

  6. Low GAS7C increases cancer cell motility by promoting N-WASP/FAK (show PTK2 Proteins)/F-actin cytoskeleton dynamics. It also enhances beta-catenin (show CTNNB1 Proteins) stability via hnRNP U (show HNRNPU Proteins)/beta-TrCP (show BTRC Proteins) complex formation.

  7. retrospectively investigated the outcome of hematopoietic stem cell transplantation in a cohort of 24 patients with the X-linked thrombocytopenia phenotype and mutations in the WAS gene

  8. This suggests that N-WASP's failure to compensate for WASP in rescuing chemotaxis could be due to the absence of this I30 region.

  9. N-WASP is downregulated in clear cell renal cell carcinoma (show MOK Proteins)

  10. Studies indicate that mutations in the Wiskott-Aldrich syndrome protein (WASp) gene cause a continuum of clinical symptoms ranging from intermittent X-linked thrombocytopenia to full classical Wiskott-Aldrich syndrome (WAS).

Mouse (Murine) Wiskott-Aldrich Syndrome-Like (WASL) interaction partners

  1. N-WASP expression in B lymphocytes is required for the development of autoimmunity of WAS (Wiskott-Aldrich syndrome) and may represent a novel therapeutic target in WAS.

  2. Data (including data from studies in knockout mice) suggest that Cnr1 (cannabinoid receptor 1 (show CNR1 Proteins)) activation impacts actin cytoskeleton polymerization/stability via Wasl in growth cones of developing neurons and in synaptic spines of mature neurons.

  3. Platelet actin nodule formation is dependent on WASp and the ARP2 (show AICDA Proteins)/3 complex. WASp(-/-) mouse blood displays impaired platelet aggregate formation at arteriolar shear rates.

  4. Our data suggests that the N-WASP-Arp2/3 actin polymerization machinery generates branched-actin arrays at an advanced stage of blood-testis barrier remodeling.

  5. Findings suggest that Wiskott-Aldrich syndrome protein (WASp) plays a crucial role in B10 cell development and that WASp-deficient B10 cells may contribute to autoimmunity in Wiskott-Aldrich syndrome.

  6. N-terminus of Cas (show CTNND1 Proteins) associates with the FAK (show PTK2 Proteins)-N-WASP complex at the protrusive edge of the cell and that the C-terminus of Cas (show CTNND1 Proteins) associates with the immobilized integrin-SFK cluster.

  7. These results strongly suggest that the association between the WASP N-terminal domain and Btk plays an important role in the TLR2-signaling pathway in macrophages.

  8. Toca-1 (show FNBP1L Proteins)(knockdown) cells have defects in formation of myotubes probably due to reduced activity of actin cytoskeleton regulators such as N-WASP.

  9. In the absence of Wiskott-Aldrich syndrome protein, effective hematopoietic stem cell mobilization is achieved.

  10. N-WASP plays a unique role in the down-regulation of BCR (show BCR Proteins) signaling at the cell surface.

Cow (Bovine) Wiskott-Aldrich Syndrome-Like (WASL) interaction partners

  1. N-WASP WWCA domains can processively attach to growing barbed-end bundles and increase their diffusion-limited elongation rate.

WASL Protein Profile

Protein Summary

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.

Alternative names and synonyms associated with WASL

  • Wiskott-Aldrich syndrome-like b (waslb)
  • Wiskott-Aldrich syndrome-like (wasl)
  • Wiskott-Aldrich syndrome-like (WASL)
  • Wiskott-Aldrich syndrome (WAS)
  • Wiskott-Aldrich syndrome (Was)
  • Wiskott-Aldrich syndrome homolog (human) (Was)
  • Wiskott-Aldrich syndrome-like (Wasl)
  • Wiskott-Aldrich syndrome-like (human) (Wasl)
  • 2900021I12Rik protein
  • 3110031I02Rik protein
  • IMD2 protein
  • N-WASP protein
  • NWASP protein
  • SCNX protein
  • THC protein
  • THC1 protein
  • TRS4 protein
  • U42471 protein
  • WASL protein
  • Wasp protein
  • zgc:55478 protein
  • zgc:77237 protein

Protein level used designations for WASL

Wiskott-Aldrich syndrome-like , Wiskott-Aldrich syndrome, like , neural Wiskott-Aldrich syndrome protein , Wiskott-Aldrich syndrome gene-like protein , eczema-thrombocytopenia , thrombocytopenia 1 (X-linked) , wiskott-Aldrich syndrome protein , Wiskott-Aldrich syndrome homolog , wiskott-Aldrich syndrome protein homolog , N-WASP

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