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BARX1 (show BARX1 ELISA Kits) functions in intestinal rotation and stomach myogenesis occur through this small group of intermediary transcription factors.
Given the important role of Barhl1 in brain development, it was proposed that perturbations of thyroid hormone (show PTH ELISA Kits) -mediated transcriptional control of Barhl1 may play a role in the impaired neurodevelopment induced by hypothyroidism.
expression of Barhl1 decelerates tumor growth both in human and in murine medulloblastomas.
Barx1 (show BARX1 ELISA Kits) control of thoracic foregut specification and tracheo-esophageal septation is tightly associated with down-regulation of adjacent Wnt (show WNT2 ELISA Kits) pathway activity
miR (show MLXIP ELISA Kits)-7a and miR (show MLXIP ELISA Kits)-203 control expression of the stomach homeotic regulator Barx1 (show BARX1 ELISA Kits).
These results suggest that Barhl1 plays an essential role in the migration and survival of cerebellar granule cells and precerebellar neurons and functionally link Barhl1 to the NT-3 (show NTF3 ELISA Kits) signaling pathway during cerebellar development
Barhl1 on the other hand was found to act as a transcriptional repressor with repressive activity not restricted to a particular domain of Barhl1.
Result suggest that Barhl1 is exclusively transcribed in restricted CNS domains at differential transcription levels which suggest a highly regulated transcriptional mechanism.
Barhl1 is crucially required for the survival but not for the specification of zonal layer neurons in the superior colliculus
High-level, cell-specific Bargl1expression in the inner ear & CNS depends on both its 5' promoter & 3' enhancer sequences. 2 homeoprotein binding motifs can be occupied & activated by Barhl1.
Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity. Binds to a regulatory module of the NCAM promoter.
bar-class homeodomain protein MBH2
, barH-like 1 homeobox protein
, barH-related homeobox protein 1
, BarH-like 2
, homeobox protein BarH-like 1