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BARX1 (show BARX1 Proteins) functions in intestinal rotation and stomach myogenesis occur through this small group of intermediary transcription factors.
Given the important role of Barhl1 in brain development, it was proposed that perturbations of thyroid hormone (show PTH Proteins) -mediated transcriptional control of Barhl1 may play a role in the impaired neurodevelopment induced by hypothyroidism.
expression of Barhl1 decelerates tumor growth both in human and in murine medulloblastomas.
Barx1 (show BARX1 Proteins) control of thoracic foregut specification and tracheo-esophageal septation is tightly associated with down-regulation of adjacent Wnt (show WNT2 Proteins) pathway activity
miR (show MLXIP Proteins)-7a and miR (show MLXIP Proteins)-203 control expression of the stomach homeotic regulator Barx1 (show BARX1 Proteins).
Data show that Barx1 (show BARX1 Proteins) antagonizes Wnt (show WNT2 Proteins) signaling, and Barx1 (show BARX1 Proteins) loss in the mesenchyme prevents stomach epithelial differentiation of overlying endoderm and induces intestine-specific genes instead.
Results describe the independent functions and mechanisms for homeobox (show PRRX1 Proteins) gene Barx1 (show BARX1 Proteins) in patterning mouse stomach and spleen.
Hoxa2 (show HOXA2 Proteins) also repressed the expression of its downstream targets Barx1 (show BARX1 Proteins) within the palate.
These results suggest that Barhl1 plays an essential role in the migration and survival of cerebellar granule cells and precerebellar neurons and functionally link Barhl1 to the NT-3 (show NTF3 Proteins) signaling pathway during cerebellar development
Barhl1 on the other hand was found to act as a transcriptional repressor with repressive activity not restricted to a particular domain of Barhl1.
Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity. Binds to a regulatory module of the NCAM promoter.
bar-class homeodomain protein MBH2
, barH-like 1 homeobox protein
, barH-related homeobox protein 1
, BarH-like 2
, homeobox protein BarH-like 1