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Browse our anti-Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) (COCH) Antibodies

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anti-Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) Antibodies (COCH)
On www.antibodies-online.com are 59 Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) (COCH) Antibodies from 12 different suppliers available. Additionally we are shipping Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) Proteins (5) and Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) Kits (2) and many more products for this protein. A total of 79 Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) products are currently listed.
Synonyms:
AW122937, COCH-5B2, COCH5B2, D12H14S564E, DFNA9
list all antibodies Gene Name GeneID UniProt
COCH 362735  
COCH 12810 Q62507
COCH 1690 O43405

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Most Popular Reactivities for anti-Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) (COCH) Antibodies

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All available anti-Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) Antibodies

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Top referenced anti-Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) Antibodies

  1. Human Polyclonal COCH Primary Antibody for EIA, FACS - ABIN951612 : Ikezono, Sugizaki, Shindo, Sekiguchi, Pawankar, Baba, Yagi: CTP (Cochlin-tomoprotein) detection in the profuse fluid leakage (gusher) from cochleostomy. in Acta oto-laryngologica 2010 (PubMed)
    Show all 5 references for ABIN951612

  2. Human Polyclonal COCH Primary Antibody for EIA, WB - ABIN951613 : Yao, Py, Zhu, Bao, Yuan: Role of protein misfolding in DFNA9 hearing loss. in The Journal of biological chemistry 2010 (PubMed)
    Show all 5 references for ABIN951613

  3. Human Polyclonal COCH Primary Antibody for WB - ABIN611208 : Anfosso, Bardin, Francès, Vivier, Camoin-Jau, Sampol, Dignat-George: Activation of human endothelial cells via S-endo-1 antigen (CD146) stimulates the tyrosine phosphorylation of focal adhesion kinase p125(FAK). in The Journal of biological chemistry 1998 (PubMed)
    Show all 4 references for ABIN611208

More Antibodies against Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) Interaction Partners

Mouse (Murine) Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) (COCH) interaction partners

  1. accumulation of acellular deposits in the incudomalleal and incudostapedi (show EPRS Antibodies)al joints in Coch (G88E/G88E) mice similar to those found in human DFNA9-affected temporal bones

  2. study reports that cochlin is expressed by follicular dendritic cells (FDCs) and selectively localized in the fine extracellular network of conduits in the spleen and lymph nodes; by producing cochlin, FDCs contribute to the innate immune response in defense against bacteria

  3. COCH is a part of the downstream target network of BMP4 (show BMP4 Antibodies) signaling and serves as another important effector to fine-tune mouse embryonic stem cell fates.

  4. Loss of Cochlin is associated with reduced intraocular pressure and mechanosensing.

  5. In Coch knock-in/knockout mouse models of sensorineural hearing loss and vestibular dysfunction vestibular function is compromised before cochlear function.

  6. Up-regulation of cochlin is an important etiologic factor leading to Usher syndrome type 1F.

  7. Areas that express COCH mRNA as determined by in situ hybridization, and to the regions of the inner ear which show histological abnormalities in autosomal dominant sensorineural deafness and vestibular disorder, DFNA9.

  8. Cochlin was found in the trabecular meshwork of very young mice, prior to elevated intraocular pressure, suggesting that over time the protein may contribute to the events leading to increased IOP and optic nerve damage--{REVIEW}

  9. introduced the G88E mutation by gene targeting into the mouse and have created a Coch(G88E/G88E) mouse model for the study of DFNA9 pathogenesis and cochlin function

Guinea Pig Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) (COCH) interaction partners

  1. The full-length 1991 bp Coch cDNA that encodes a 553 amino acid protein was isolated; the sequence had significant homology with other mammals.

Human Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) (COCH) interaction partners

  1. COCH expression is significantly downregulated in human masticatory mucosa during wound healing

  2. Distinct vestibular phenotypes depending on the location of COCH mutations were demonstrated, and this study correlates a genotype of p.G38D in COCH to the phenotype of bilateral total vestibular loss, therefore expanding the vestibular phenotypic spectrum of DFNA9 to range from bilateral vestibular loss without episodic vertigo to MD-like features with devastating episodic vertigo

  3. This study showed that Mendelian sensorineural hearing loss exhibits vestibular dysfunction, including DFNA9, DFNA11 (show MYO7A Antibodies), DFNA15 (show POU4F3 Antibodies) and DFNA28 (show GRHL2 Antibodies).

  4. the impaired post-translational cleavage of cochlin mutants may be associated with pathological mechanisms underlying DFNA9-related sensorineural hearing loss.

  5. This family is the first case of a truncating COCH variant and supports the hypothesis that COCH haploinsufficiency is not the cause of hearing loss in humans.

  6. Targeted exon resequencing of selected genes using next-generation sequencing identified 3 COCH (one known, two novel) mutations in a cohort of hearing loss patients in Japan.

  7. This is the first report showing failure of mutant cochlin transport through the secretory pathway, abolishment of cochlin secretion, and formation and retention of dimers and large multimeric intracellular aggregates

  8. prominent in the incudomalleal joint, incudostapedial joint, and the pars (show EPRS Antibodies) tensa of the tympanic membrane

  9. A new phenotypic and characteristic radiologic feature of DFNA9 has been discovered.

  10. new variants in genes such as COCH is associated with nonsyndromic deafness and vestibular dysfunction.

Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) (COCH) Antigen Profile

Antigen Summary

The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.

Alternative names and synonyms associated with Coagulation Factor C Homolog, Cochlin (Limulus Polyphemus) (COCH)

  • cochlin (Coch) antibody
  • coagulation factor C homolog (Limulus polyphemus) (Coch) antibody
  • coagulation factor C homolog, cochlin (Limulus polyphemus) (COCH) antibody
  • cochlin (COCH) antibody
  • AW122937 antibody
  • COCH-5B2 antibody
  • COCH5B2 antibody
  • D12H14S564E antibody
  • DFNA9 antibody

Protein level used designations for COCH

coagulation factor C homolog (Limulus polyphemus) , coagulation factor C homolog, cochlin (Limulus polyphemus) , cochlin , Coch-5B2

GENE ID SPECIES
362735 Rattus norvegicus
12810 Mus musculus
100174920 Cavia porcellus
504316 Bos taurus
395779 Gallus gallus
1690 Homo sapiens
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