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anti-Rat (Rattus) DIAPH1 Antibodies:
anti-Mouse (Murine) DIAPH1 Antibodies:
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Human Polyclonal DIAPH1 Primary Antibody for WB - ABIN153169
Minin, Kulik, Gyoeva, Li, Goshima, Gelfand: Regulation of mitochondria distribution by RhoA and formins. in Journal of cell science 2006
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Dog (Canine) Monoclonal DIAPH1 Primary Antibody for IF, IP - ABIN968212
Li, Higgs: The mouse Formin mDia1 is a potent actin nucleation factor regulated by autoinhibition. in Current biology : CB 2003
Show all 3 Pubmed References
Dog (Canine) Monoclonal DIAPH1 Primary Antibody for IF, IP - ABIN968213
Pennisi: The architecture of hearing. in Science (New York, N.Y.) 1997
Show all 3 Pubmed References
Human Polyclonal DIAPH1 Primary Antibody for ICC, IF - ABIN153170
Jewett, Fischer, Mead, Hackstadt: Chlamydial TARP is a bacterial nucleator of actin. in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 2 Pubmed References
Human Polyclonal DIAPH1 Primary Antibody for IHC, IHC (p) - ABIN4305203
Goel, Sienkiewicz, Picciani, Lee, Bhattacharya: Cochlin induced TREK-1 co-expression and annexin A2 secretion: role in trabecular meshwork cell elongation and motility. in PLoS ONE 2011
these results uncover a novel role for mDia1 in Abeta (show APP Antibodies)-mediated synaptotoxicity and demonstrate that inhibition of MT dynamics and accumulation of PTMs (show PTMS Antibodies) are driving factors for the induction of tau-mediated neuronal damage.
Small Molecule Inhibition of Ligand-Stimulated RAGE (show AGER Antibodies)-DIAPH1 Signal Transduction.
Diaphanous-related formin (show DIAPH3 Antibodies) signaling plays a role in heart and vascular development and the maintenance of SMC (show DYM Antibodies) phenotype.
Liprin-alpha3 (show PPFIA3 Antibodies) uses an alpha-helical region to bind to mDia1, counteracting mouse Dia1 (show CYB5R3 Antibodies) activation by RhoA (show RHOA Antibodies).
Depleting FMNL1 (show FMNL1 Antibodies), another Formin (show FMN1 Antibodies) family member, resulted in reduced mDia1 expression, while RhoA (show RHOA Antibodies) inhibition did not alter mDia1 expression, which indicated that there was a FMNL1 (show FMNL1 Antibodies)-mDia1-Profilin1 (show PFN1 Antibodies) signaling pathway in mouse oocytes.
Mechanistically, mDia1 deficiency led to a downregulation of membrane-associated genes and a specific upregulation of CD14 (show CD14 Antibodies) messenger RNA in granulocytes, but not in other lineages.
Mammalian diaphanous-related formin 1 regulates GSK3beta (show GSK3b Antibodies)-dependent microtubule dynamics required for T cell migratory polarization.
mDia1 can efficiently put actin filaments under mechanical tension.
The active form of mDia1 localized to the apical membrane in exocrine pancreas cells; introduction of an active form of mDia1 leads to a marked increase in actin bundle density along the secretory vesicle lumen perimeter.
Dia1 (show CYB5R3 Antibodies) and Dia2 (show DIAPH3 Antibodies) are dynamic components of meiotic spindle and pole complex during meiotic maturation of oocytes.
DIAPH1 interaction with the RAGE (show AGER Antibodies) cytoplasmic domain. [review]
Ligand-induced association of RAGE (show AGER Antibodies) homodimers on the cell surface increases the molecular dimension of the receptor, recruiting DIAPH1 and activating signaling pathways.
The authors describe a novel patient-derived DIAPH1 mutation (c.3610C>T) in two unrelated families, which results in early termination prior to a basic amino acid motif (RRKR(1204-1207)) at the DAD C-terminus. The mutant DIA1 (show CYB5R3 Antibodies)(R1204X) disrupted the autoinhibitory DID-DAD interaction and was constitutively active.
The description of a novel disorder of platelet formation and hearing loss extends the repertoire of DIAPH1-related disease, and provides new insight into the autoregulation of DIAPH1 activity.
Studies indicate that diaphanous related formin 1 (DIAPH1) is essentially involved in microtubules (MTs (show TIMM8A Antibodies))-dependent early adhesion of colon cancer cells.
A 51-year-old patient in a Korean family with ADNSHL was examined by pure-tone audiometry, and genetic analysis of DIAPH1 was performed. A novel variant, p.I530S (c.1589T > G), was identified in the DIAPH1 gene, and the mutation was located in the highly conserved coiled-coil domain of the DIA1 (show CYB5R3 Antibodies) protein.
mDia1 is an important regulator of breast cancer cell invasion and that its effects may be mediated by MMP-2 (show MMP2 Antibodies) activity.
Findings suggest that regulation of cellular trafficking and microtubule-mediated localization of MT1-MMP (show MMP14 Antibodies) by mDia1 is likely important in breast cancer invasion through the expression of cancer stem cell genes.
Loss-of-function variants in DIAPH1 is associated with syndromic microcephaly, blindness, and early onset seizures.
functional complementation experiments and optogenetics to show that mDia1 cooperates with the Arp2 (show ACTR2 Antibodies)/3 complex in initiating lamellipodia and ruffles.
This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
diaphanous homolog 1 (Drosophila)
, diaphanous homolog 1
, diaphanous homolog 2
, protein diaphanous homolog 1
, protein diaphanous homolog 1-like
, diaphanous-related formin-1