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Browse our DIAPH1 Proteins (DIAPH1)

Full name:
Diaphanous Homolog 1 (Drosophila) Proteins (DIAPH1)
On are 5 Diaphanous Homolog 1 (Drosophila) (DIAPH1) Proteins from 3 different suppliers available. Additionally we are shipping DIAPH1 Antibodies (65) and DIAPH1 Kits (2) and many more products for this protein. A total of 77 DIAPH1 products are currently listed.
D18Wsu154e, DFNA1, DIA1, Diap1, Diaph1, DIAPH2, DRF1, hDIA1, LFHL1, mKIAA4062, p140mDia
list all proteins Gene Name GeneID UniProt
Rat DIAPH1 DIAPH1 307483  
DIAPH1 13367 O08808
DIAPH1 1729 O60610

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DIAPH1 Proteins (DIAPH1) by Origin

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More Proteins for DIAPH1 Interaction Partners

Mouse (Murine) Diaphanous Homolog 1 (Drosophila) (DIAPH1) interaction partners

  1. Small Molecule Inhibition of Ligand-Stimulated RAGE (show AGER Proteins)-DIAPH1 Signal Transduction.

  2. Diaphanous-related formin (show DIAPH3 Proteins) signaling plays a role in heart and vascular development and the maintenance of SMC (show DYM Proteins) phenotype.

  3. Liprin-alpha3 (show PPFIA3 Proteins) uses an alpha-helical region to bind to mDia1, counteracting mouse Dia1 (show CYB5R3 Proteins) activation by RhoA (show RHOA Proteins).

  4. Depleting FMNL1 (show FMNL1 Proteins), another Formin (show FMN1 Proteins) family member, resulted in reduced mDia1 expression, while RhoA (show RHOA Proteins) inhibition did not alter mDia1 expression, which indicated that there was a FMNL1 (show FMNL1 Proteins)-mDia1-Profilin1 (show PFN1 Proteins) signaling pathway in mouse oocytes.

  5. Mechanistically, mDia1 deficiency led to a downregulation of membrane-associated genes and a specific upregulation of CD14 (show CD14 Proteins) messenger RNA in granulocytes, but not in other lineages.

  6. Mammalian diaphanous-related formin 1 regulates GSK3beta-dependent microtubule dynamics required for T cell migratory polarization.

  7. mDia1 can efficiently put actin filaments under mechanical tension.

  8. The active form of mDia1 localized to the apical membrane in exocrine pancreas cells; introduction of an active form of mDia1 leads to a marked increase in actin bundle density along the secretory vesicle lumen perimeter.

  9. Dia1 and Dia2 are dynamic components of meiotic spindle and pole complex during meiotic maturation of oocytes.

  10. Actin-capping protein is a novel regulator of microtubule stability that functions by antagonizing mDia1 activity toward actin filaments.

Human Diaphanous Homolog 1 (Drosophila) (DIAPH1) interaction partners

  1. mDia1 is an important regulator of breast cancer cell invasion and that its effects may be mediated by MMP-2 (show MMP2 Proteins) activity.

  2. Findings suggest that regulation of cellular trafficking and microtubule-mediated localization of MT1-MMP (show MMP14 Proteins) by mDia1 is likely important in breast cancer invasion through the expression of cancer stem cell genes.

  3. Loss-of-function variants in DIAPH1 is associated with syndromic microcephaly, blindness, and early onset seizures.

  4. functional complementation experiments and optogenetics to show that mDia1 cooperates with the Arp2 (show ACTR2 Proteins)/3 complex in initiating lamellipodia and ruffles.

  5. Capping protein and dia1 (show CYB5R3 Proteins) functionally coregulate filament barbed-end assembly.

  6. mDia1 displaced from the barbed end by CapZ Actin Capping Protein can randomly slide along the actin filament and later return.

  7. Data indicate that diaphanous homolog 1 (Drosophila) protein (DIAPH1) stabilizes microtubules and reduces microtubule dynamics.

  8. Patients with a homozygous nonsense DIAPH1 alteration (p.Gln778*) have MCP (show CD46 Proteins) as well as reduced height and weight.

  9. the RhoA (show RHOA Proteins)-regulated formin (show FMN1 Proteins) Dia1 (show CYB5R3 Proteins) is involved in entosis downstream of LPAR2 (show LPAR2 Proteins)

  10. DIAPH1 has a critical role in generating F-actin structures and assisting the microtubule stabilization underlying proplatelet formation and platelet production

DIAPH1 Protein Profile

Protein Summary

This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Alternative names and synonyms associated with DIAPH1

  • diaphanous homolog 1 (Drosophila) (DIAPH1)
  • diaphanous-related formin 1 (DIAPH1)
  • diaphanous-related formin 1 (diaph1)
  • diaphanous-related formin 1 (Diaph1)
  • diaphanous homolog 1 (Drosophila) (diaph1)
  • diaphanous homolog 1 (Drosophila) (Diap1)
  • D18Wsu154e protein
  • DFNA1 protein
  • DIA1 protein
  • Diap1 protein
  • Diaph1 protein
  • DIAPH2 protein
  • DRF1 protein
  • hDIA1 protein
  • LFHL1 protein
  • mKIAA4062 protein
  • p140mDia protein

Protein level used designations for DIAPH1

diaphanous homolog 1 (Drosophila) , diaphanous homolog 1 , diaphanous homolog 2 , protein diaphanous homolog 1 , protein diaphanous homolog 1-like , diaphanous-related formin-1 , mDIA1

100684883 Canis lupus familiaris
700918 Macaca mulatta
786565 Bos taurus
733754 Xenopus (Silurana) tropicalis
100072186 Equus caballus
374040 Gallus gallus
307483 Rattus norvegicus
100457442 Pongo abelii
100478130 Ailuropoda melanoleuca
100562222 Anolis carolinensis
13367 Mus musculus
1729 Homo sapiens
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