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Comparative mapping of Y1 and Y5 receptor (show NPY5R ELISA Kits) subtypes within cell bodies and nerve fibers in the brain. Together with physiological and electrophysiological studies, provides better understanding of NPY (show NPY ELISA Kits) neural circuitries.
Thus, in contrast to connexin32 (show GJB1 ELISA Kits) and connexin47, which are also expressed in myelinating cells, Cx29 does not contribute to the function of myelin in adult mice.
Homomeric interactions of Cx29 and Cx32 (show GJB1 ELISA Kits) require other domains: the N-terminus, transmembrane domains, and extracellular loops. Substituting the intracellular loop and/or tail of Cx32 (show GJB1 ELISA Kits) with those of Cx29 prevents Cx32 (show GJB1 ELISA Kits) from forming functional gap junctions.
Cx23 seems to share functional properties with pannexin (hemi) channels rather than gap junction channels of other connexins.
Based on these findings, we suggest that p.W77S mutant has a dominant negative effect on the formation and function of the gap junction. These results give a novel molecular elucidation for the mutation of GJC3 in the development of hearing loss.
Although p.R15G and p.L23H mutants do not decrease the trafficking of CX proteins, mutations in GJC3 genes result in a loss of hemichannel function of CX30.2/CX31.3 protein, possibly causing hearing loss.
Cx31.3 is localized to the gray matter along small myelinated fibers and is co-expressed with Cx32 (show GJB1 ELISA Kits) in oligodendrocytes.
This gene encodes a gap junction protein. The encoded protein, also known as a connexin, plays a role in formation of gap junctions, which provide direct connections between neighboring cells. Mutations in this gene have been reported to be associated with nonsyndromic hearing loss.
gap junction protein, gamma 3, 30.2kDa
, connexin 29
, gap junction epsilon-1 protein
, gap junction gamma-3 protein
, gap junction membrane channel protein epsilon 1