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Multiple genetic models identified 1 significant locus, GRM7, for 2 hypertension-derived traits.
Study represents a genetic association test towards single variant and multi-markers interaction of GRM7 and GRM8 genes in both schizophrenia and major depressive disorders in Han Chinese population
Glutamate (show GRIN1 Proteins) system genes have been associated with disease risk in recent analyses from the Psychiatric Genomics Consortium.
results indicate that the GRM7 SNPs rs13353402 and rs1531939 might be associated with schizophrenia in Chinese Han population.
results reported here do not support a role for GRM7 in ADHD
Copy number variants at GRM7 may have a role in the etiology of bipolar disorder.
For neither PCLO nor GRM7 we found a more associated variant. For SLC6A4 (show SLC6A4 Proteins), we found a new SNP that showed a lower P-value than in the GAIN-MDD GWAS
in an elderly male Han Chinese population, GRM7 SNP rs11928865 (TT) occurs more frequently in age-related hearing impairment patients with SL and AL phenotype patterns.
These results provide preliminary evidence of an association between the GRM7 rs37952452 polymorphism and selective attention deficit and anxiety found within the Korean ADHD population
Mixed modeling analyses explored the relationship of GRM7 haplotype and SNP genotypes with measures of auditory perception. GRM7 alleles are associated primarily with peripheral measures of hearing loss, and with speech detection in older adults.
This study provides evidence for mGlu7 receptor-mediated tonic modulation of a physiological function in vivo preventing synchronous and potentially pathological oscillations.
Analysis of mGluR7 (show GRM2 Proteins) KO mice, c-Fos expression, and cerebral MMPIP microinjection indicate that inhibition of mGluR7 (show GRM2 Proteins) impairs intermale aggression owing to information processing dysfunction within the bed nucleus of the stria terminalis
muscle does not appear to require high levels of SMN (show STMN1 Proteins) above what is produced by two copies of SMN2 (show SMN1 Proteins)
SAM68 (show KHDRBS1 Proteins) is a physiological regulator of SMN2 (show SMN1 Proteins) splicing in a spinal muscular atrophy mouse model.
Hyperoxia treatment increased the inclusion of SMN2 (show SMN1 Proteins) exon 7 in skeletal muscles and resulted in improved motor function.
Elfn1 (show ELFN1 Proteins) recruits mGluR7 (show GRM2 Proteins) to synaptic sites.A trans interaction of Elfn1 (show ELFN1 Proteins) and mGluR7 (show GRM2 Proteins) controls targeted interneuron synapse development.
GRM7 regulates the phosphorylation of CREB (show CREB1 Proteins) protein and the expression of Yes-associated protein (YAP (show YAP1 Proteins)) by directly interacting with CaM (show Calm2 Proteins), which subsequently regulates the expression of CyclinD1 and ultimately affects early cortical development.
Modeling the selective interaction between XAP044 and mGlu7's Venus flytrap domain, whose three-dimensional structure is already known, will facilitate future drug development supported by computer-assisted drug design
The data of this study revealed very different roles for mGlu7 in amygdala synaptic transmission, fear learning and its expression
These data suggest targeting mGlu7 receptors with selective antagonist drugs may be an effective and safe strategy for the treatment of anxiety disorders.
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.
metabotropic glutamate receptor 7
, G protein-coupled receptor GRM7
, G protein-coupled receptor, family C, group 1, member G
, mGlu7a receptor
, metabotropic glutamate receptor mGluR7
, metabotropic glutamate receptor subtype 7b