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these observations suggest that M-LPH is involved in the maintenance of mtDNA and protects cells from mitochondrial dysfunction.
In mice, M-LPs (show TLR4 ELISA Kits) is expressed exclusively in kidneys after 6 weeks. Transfection with M-LPS (show TLR4 ELISA Kits) up-regulates SOD2 (show SOD2 ELISA Kits) and down-regulates cellular glutathione peroxidase (Gpx1 (show GPX1 ELISA Kits)) and plasma glutathione peroxidase (Gpx3 (show GPX3 ELISA Kits)) gene expression
identify Mpv17l as a unique interacting protein and regulator of HtrA2 (show HTRA2 ELISA Kits) protease mediating antioxidant and antiapoptotic function in mitochondria
Participates in reactive oxygen species metablism by up- or down-regulation of the genes of antioxidant enzymes (By similarity).
Mpv17 transgene, kidney disease mutant-like
, protein Mpv17
, mpv17-like protein
, MPV17 mitochondrial membrane protein-like
, M-LP homolog
, Mpv17-like protein type 1
, Mpv17-like protein type 2