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Browse our POU Domain, Class 3, Transcription Factor 4 Proteins (POU3F4)

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POU Domain, Class 3, Transcription Factor 4 Proteins (POU3F4)
On www.antibodies-online.com are 8 POU Domain, Class 3, Transcription Factor 4 (POU3F4) Proteins from 4 different suppliers available. Additionally we are shipping POU Domain, Class 3, Transcription Factor 4 Antibodies (6) and POU Domain, Class 3, Transcription Factor 4 Kits (3) and many more products for this protein. A total of 19 POU Domain, Class 3, Transcription Factor 4 products are currently listed.
Synonyms:
Brain-4, Brn-4, Brn4, DFN3, DFNX2, oct-9, OTF-9, Otf9, pou2, POU 2, pou3f4-a, RHS2, Slf, XlPOU-2, XlPOU2
list all proteins Gene Name GeneID UniProt
POU3F4 5456 P49335
POU3F4 29589 P62516
POU3F4 18994 P62515

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POU Domain, Class 3, Transcription Factor 4 Proteins (POU3F4) by Origin

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More Proteins for POU Domain, Class 3, Transcription Factor 4 Interaction Partners

Human POU Domain, Class 3, Transcription Factor 4 (POU3F4) interaction partners

  1. A nonsense mutation is identified in a family displaying the pedigree consistent with X-linked recessive pattern in POU3F4 gene.

  2. POU3F4 mutation in profoundly deaf patients may have poorer prognosis after cochlear implantation, than other types.

  3. findings may greatly contribute to the elucidation of the roles of the Oct (show Plxna2 Proteins) and Myc (show MYC Proteins) proteins in osteoblast direct reprogramming. The results may also lead to establishment of novel regenerative therapy for various bone resorption diseases

  4. Audiological, medical, and family histories were collected and family members interviewed to compare hearing thresholds and case histories between cases with mutations in SMPX (show SMPX Proteins) versus POU3F4.

  5. Our data suggest that different POU3F4 mutations might show different recurrence rate in siblings of the incomplete partition type III anomaly especially in East Asian population

  6. POU3F4 mutations are associated with X-linked deafness

  7. We concluded that the probable presence of the third window effect is not limited to the particular type of POU3F4 mutation.

  8. Results show three novel mutations in the POU3F4 gene resulting in profound hearing loss in both humans and mice.

  9. Frameshift truncation and extension mutations in the C-terminus of POU3F4 lead to cytoplasmic localization and subsequent proteosomal degradation due to structural aberrations, which cause transcriptional inactivity and thus nonsyndromic hearing loss.

  10. Study found no mutations in GJB6 (show GJB6 Proteins) or POU3F4 in nonsyndromic Tibetan Chinese patients with hearing impairment.

Xenopus laevis POU Domain, Class 3, Transcription Factor 4 (POU3F4) interaction partners

  1. pou3f4 expression in inner ear might be under the control of distinct regulatory elements that fine-tune the spatio-temporal activity of this gene

Mouse (Murine) POU Domain, Class 3, Transcription Factor 4 (POU3F4) interaction partners

  1. Brn4 substantially contributes to cochlear gap junction properties to maintain the proper EP in cochleae, similar to connexin-related deafness.

  2. Efnb2 (show EFNB2 Proteins) expression was attenuated in Pou3f4 hemizygous null mutants relative to control.

  3. Results show three novel mutations in the POU3F4 gene resulting in profound hearing loss in both humans and mice.

  4. This study indicated a model whereby Pou3f4 in the otic mesenchyme establishes an Eph/ephrin-mediated fasciculation signal that promotes inner radial bundle formation.

  5. pou3f4 expression in inner ear might be under the control of distinct regulatory elements that fine-tune the spatio-temporal activity of this gene

  6. The effects of Brn-4 on the neuronal differentiation and development of neural stem cells, were investigated.

  7. a transcription factor targeted to the early mouse pancreas induces ectopic glucagon (show GCG Proteins) gene expression

  8. late-onset effect of Brn-4 deficiency on the hearing organ of the mouse. About one third of heterozygous female mice revealed late-onset profound deafness at the age of 1 year.

  9. lack of role in regulating Pax6 (show PAX6 Proteins) and Nkx2.2 (show Nkx2-2 Proteins)

  10. Tbx1 (show TBX1 Proteins) and Brn4 function in signaling from the periotic mesenchyme to the otic vesicle to direct proper coiling of the cochlear duct.

POU Domain, Class 3, Transcription Factor 4 (POU3F4) Protein Profile

Protein Summary

This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness.

Alternative names and synonyms associated with POU Domain, Class 3, Transcription Factor 4 (POU3F4)

  • POU class 3 homeobox 4 (POU3F4)
  • POU class 3 homeobox 4 (pou3f4)
  • POU class 3 homeobox 4 (Pou3f4)
  • POU domain, class 3, transcription factor 4 (Pou3f4)
  • Brain-4 protein
  • Brn-4 protein
  • Brn4 protein
  • DFN3 protein
  • DFNX2 protein
  • oct-9 protein
  • OTF-9 protein
  • Otf9 protein
  • pou2 protein
  • POU 2 protein
  • pou3f4-a protein
  • RHS2 protein
  • Slf protein
  • XlPOU-2 protein
  • XlPOU2 protein

Protein level used designations for POU3F4

POU domain, class 3, transcription factor 4 , POU class 3 homeobox 4 , POU domain, class 3, transcription factor 4-like , brain-specific homeobox/POU domain protein 4 , octamer-binding transcription factor 9 , POU 2 transcription factor , POU domain, class 3, transcription factor 4-A , Transcription factor POU2 , XLPOU 2 , xlPOU2 , OTF-9 , RHS2 class III POU protein , brain-4 , brn-4 , oct-9 , octamer-binding protein 9 , Brain-specific homeobox/POU domain protein 4 , POU homeodomain protein , brain-4 class III POU-domain protein , sex linked fidget

GENE ID SPECIES
539732 Bos taurus
100152446 Sus scrofa
100036711 Xenopus (Silurana) tropicalis
100472065 Ailuropoda melanoleuca
5456 Homo sapiens
397929 Xenopus laevis
491988 Canis lupus familiaris
29589 Rattus norvegicus
101829289 Mesocricetus auratus
18994 Mus musculus
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