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Browse our SCN8A (SCN8A) ELISA Kits

Full name:
Sodium Channel, Voltage-Gated, Type VIII, alpha ELISA Kits (SCN8A)
On www.antibodies-online.com are 1 Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A) ELISA Kits from 1 different suppliers available. Additionally we are shipping SCN8A Antibodies (52) and SCN8A Proteins (11) and many more products for this protein. A total of 70 SCN8A products are currently listed.
Synonyms:
AI853486, C630029C19Rik, CERIII, CIAT, dmu, EIEE13, med, mnd-2, mnd2, NaCh6, Nav1.6, nmf2, nmf58, nmf335, nur14, PN4, seal
list all ELISA KIts Gene Name GeneID UniProt
SCN8A 6334 Q9UQD0
Rat SCN8A SCN8A 29710 O88420
Mouse SCN8A SCN8A 20273 Q9WTU3

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SCN8A (SCN8A) ELISA Kits by Reactivity

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More ELISA Kits for SCN8A Interaction Partners

Human Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A) interaction partners

  1. Either the FGF14 (show FGF14 ELISA Kits)(V160A) or the FGF14 (show FGF14 ELISA Kits)(K74A/I76A) mutation was sufficient to abolish the FGF14 (show FGF14 ELISA Kits)-dependent regulation of peak transient Na(+) currents and the voltage-dependent activation and steady-state inactivation of Nav1.6; but only V160A with a concomitant alanine mutation at Tyr (show TYR ELISA Kits)-158 could impede FGF14 (show FGF14 ELISA Kits)-dependent modulation of the channel fast inactivation.

  2. we report an infant and his father with early onset focal epileptic seizures but without cognitive or neurological impairment in whom next generation sequence analysis identified a heterozygous mutation (c.5630A > G, p. (Asn1877Ser)) in the SCN8A gene

  3. the calpain-dependent cleavage of Nav1.6 channels expressed in human embryonic kidney (HEK) 293 cells caused the upregulation of I(NaP)

  4. Our study establishes SCN8A as a novel gene in which a recurrent mutation causes BFIS/ICCA, expanding the clinical-genetic spectrum of combined epileptic and dyskinetic syndromes.

  5. Human Nav1.6 channels generate larger resurgent currents than human Nav1.1 (show SCN1A ELISA Kits) channels, but the SCN4B (show SCN4B ELISA Kits)-derived Navbeta4 (show SCN4B ELISA Kits) peptide does not protect either isoform from use-dependent reduction.

  6. These data strengthen previous findings linking gain-of-function mutations of SCN8A with EIEE and demonstrate the importance of functional testing in establishing the pathogenicity of de novo mutations.

  7. Expression profiling of SCN8A and NDUFC2 (show NDUFC2 ELISA Kits) genes in colorectal carcinoma is reported. There was no NDUFC2 (show NDUFC2 ELISA Kits) differential expression in colorectal carcinoma.

  8. Epileptic encephalopathy related to mutations in the SCN8A genes.

  9. SCN8A encephalopathy presents in infancy with multiple seizure types.

  10. The results of this study suggested that SCN8A mutation cause early onset epilepsy and intellectual disability.

Mouse (Murine) Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A) interaction partners

  1. The clinical phenotype of the severe hypomorphic sodium channel gene SCN8A mutant expands the spectrum of Scn8a disease to include a recessively inherited, chronic and progressive movement disorder.

  2. the presences of Nav1.1 (show SCN1A ELISA Kits), Nav1.6, Navbeta1 and Navbeta3 mRNA and their reduced levels in rat SAN during aging.

  3. This study demonstrates that Nav channel expression in lumbar motoneurons is altered after SCI, and it shows a tight relationship between the calpain-dependent proteolysis of Nav1.6 channels, the upregulation of I(NaP (show CTNNBL1 ELISA Kits)) and spastici

  4. the role of Nav1.6 in general anesthesia using two mouse mutants with reduced activity of Nav1.6, was examined.

  5. observed increased hippocampal pyramidal cell excitability in heterozygous and homozygous Scn8a-R1627H mutants, and decreased interneuron excitability in heterozygous Scn8a-R1627H mutants.

  6. The data support a model where ankyrinG (show ANK3 ELISA Kits)-binding is required for preferential Nav1.6 insertion into the axon initial segment plasma membrane during development.

  7. the degenerating muscle mutation is a loss of function mutation of scn8a

  8. N1768D mutation of SCN8A is sufficient to induce seizures and SUDEP in knock-in mice.

  9. APP (show APP ELISA Kits) enhances Nav1.6 sodium channel cell surface expression through a Go-coupled JNK (show MAPK8 ELISA Kits) pathway

  10. This study provided evidence for a direct link between sodium channel activity and modulation of Rac1 and ERK1/2 (show MAPK1/3 ELISA Kits) activation in ATP-stimulated microglia, possibly by regulating Ca(2 (show CA2 ELISA Kits)+) transients

SCN8A Antigen Profile

Antigen Summary

This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with SCN8A

  • sodium channel, voltage gated, type VIII, alpha subunit (SCN8A) Elisa Kit
  • sodium channel, voltage gated, type VIII, alpha subunit (Scn8a) Elisa Kit
  • sodium channel, voltage-gated, type VIII, alpha (Scn8a) Elisa Kit
  • AI853486 Elisa Kit
  • C630029C19Rik Elisa Kit
  • CERIII Elisa Kit
  • CIAT Elisa Kit
  • dmu Elisa Kit
  • EIEE13 Elisa Kit
  • med Elisa Kit
  • mnd-2 Elisa Kit
  • mnd2 Elisa Kit
  • NaCh6 Elisa Kit
  • Nav1.6 Elisa Kit
  • nmf2 Elisa Kit
  • nmf58 Elisa Kit
  • nmf335 Elisa Kit
  • nur14 Elisa Kit
  • PN4 Elisa Kit
  • seal Elisa Kit

Protein level used designations for SCN8A

hNa6/Scn8a voltage-gated sodium channel , sodium channel protein type 8 subunit alpha , voltage-gated sodium channel subunit alpha Nav1.6 , Na+ channel , PN4 , naCh6 , peripheral nerve protein type 4 , sodium channel 6 , sodium channel protein type VIII subunit alpha , sodium channel voltage-gated type VIII alpha polypeptide , sodium channel, voltage-gated, type 8, alpha polypeptide , sodium channel, voltage-gated, type 8, alpha subunit , sodium channel, voltage-gated, type VIII, alpha polypeptide , ataxia 3

GENE ID SPECIES
6334 Homo sapiens
477604 Canis lupus familiaris
29710 Rattus norvegicus
537277 Bos taurus
20273 Mus musculus
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