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Human Polyclonal SCO1 Primary Antibody for IHC, ELISA - ABIN1003126
Glerum, Shtanko, Tzagoloff: SCO1 and SCO2 act as high copy suppressors of a mitochondrial copper recruitment defect in Saccharomyces cerevisiae. in The Journal of biological chemistry 1996
Show all 4 Pubmed References
Human Polyclonal SCO1 Primary Antibody for ICC, IF - ABIN4352258
Rolland, Motori, Memar, Hench, Frank, Winklhofer, Conradt: Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion. in Proceedings of the National Academy of Sciences of the United States of America 2013
C-kit (show KIT Antibodies)-positive hematopoietic stem/progenitor cells expressed significantly higher of Nox1 (show NOX1 Antibodies) and catalase (show CAT Antibodies), but less of lactoperoxidase (show LPO Antibodies) than in matured mononuclear cells.
c-KIT (show KIT Antibodies) signaling regulates self-renewal capacity and prevents neurodifferentiation in culture.
These findings identify functional redundancy among Kit-dependent hematopoietic lineages and establish an unanticipated capacity of megakaryocytes to mediate IL-1 (show IL1A Antibodies)-driven systemic inflammatory disease.
WNT (show WNT2 Antibodies) signaling at an early stage (E12 (show ELSPBP1 Antibodies)-E15) of submandibular salivary gland (SMG (show SNRPG Antibodies)) development inhibits end bud morphogenesis and differentiation into proacini by suppressing Kit expression.
c-kit (show KIT Antibodies) can reduce inflammation, positively modulate airway remodeling, and improve function in a mouse model of airway hyperresponsiveness
Kit inactivation within oocytes also led to premature ovarian failure, albeit via a contrasting phenotype. Despite normal initial complements of primordial follicles, oocytes remained dormant with arrested oocyte maturation. Foxo3 (show FOXO3 Antibodies) protein localization in the nucleus versus cytoplasm explained both mutant phenotypes.
sca-1 (show Ly6a Antibodies) antibody reduces both CD34 (show CD34 Antibodies)+/c-kit (show KIT Antibodies)+ progenitor cell surge and vascular restenosis after endoluminal vascular injury in a murine model.
These findings indicate the SCF (show KITLG Antibodies)/Kit signaling insufficiency may contribute to the underdevelopment of ICCs and intestinal motility dysfunction upon hypoxia exposure.
we identified important roles for the GATA-2 C-ZnF in bone marrow hematopoiesis via control of c-Kit expression and HSC/HSPC survival.
IMC-G4 cells had an additional novel c-kit (show KIT Antibodies) gene mutation of KIT-Tyr421Cys which is considered to induce neoplastic transformation of mouse mast cells
Results find that COA6 associates with COX2 (show COX2 Antibodies) and is crucial for its maturation and complex IV biogenesis. Also, COA6 interacts with the copper chaperone SCO1 which indicates that COA6 is intrinsically involved in the copper delivery process for COX2 (show COX2 Antibodies).
Sco1 is a metallochaperone that selectively transfers Cu(I) ions based on loop recognition, whereas Sco2 is a copper-dependent thiol reductase of the cysteine ligands in the oxidase.
COX20 cooperates with SCO1 and SCO2 (show SCO2 Antibodies) to mature COX2 (show COX2 Antibodies) and promote the assembly of cytochrome c (show CYCS Antibodies) oxidase.
COX19 (show COX19 Antibodies) is necessary for the transduction of a SCO1-dependent mitochondrial redox signal that regulates ATP7A (show ATP7A Antibodies)-mediated cellular copper efflux.
Results describe the tissue distribution of SCO1 and SCO2 in mouse and human tissues.
SCO1 facilitates the transfer of copper from SCO2 (show SCO2 Antibodies) to the CuA site at an early stage of COX (show COX8A Antibodies) assembly in mitochondria.
data suggest that both Cu(I) and Cu(II) binding are critical for normal Sco (show SNAI1 Antibodies) function.
Cox17-mediated copper metallation of Sco1, as well as the subsequent failure of Cu(A) site maturation, is the basis for the inefficient assembly of the cytochrome c oxidase complex in SCO1 patients
Sco1 has evolved to bind a metal atom via the di-Cys (show DNAJC5 Antibodies) motif to act as a copper chaperone, the oxidized form of the nickel-bound protein suggests that it may also maintain the thioredoxin (show TXN Antibodies) function.
These results suggest a mitochondrial pathway for the regulation of cellular copper content that involves signaling through SCO1 and SCO2, perhaps by their thiol redox or metal-binding state.
Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene.
Dominant white spotting
, Steel Factor Receptor
, c-kit proto-oncogene protein
, dominant spotting
, mast/stem cell growth factor receptor Kit
, proto-oncogene c-Kit
, proto-oncogene tyrosine-protein kinase Kit
, spotted sterile male
, tyrosine-protein kinase Kit
, protein SCO1 homolog, mitochondrial
, SCO cytochrome oxidase deficient homolog 1