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Human Polyclonal SIX1 Primary Antibody for ICC, IF - ABIN4353939
Wan, Miao, Quraishi, Kennedy, Creek, Pirisi: Gene expression changes during HPV-mediated carcinogenesis: a comparison between an in vitro cell model and cervical cancer. in International journal of cancer 2008
Show all 15 Pubmed References
Human Polyclonal SIX1 Primary Antibody for ELISA - ABIN562881
Gordon, Delgado Díaz, White, Carson, Kostek: Six1 and Six1 cofactor expression is altered during early skeletal muscle overload in mice. in The journal of physiological sciences : JPS 2012
Show all 2 Pubmed References
Cow (Bovine) Polyclonal SIX1 Primary Antibody for IHC, WB - ABIN2779599
Lee, Kim, Ryu, Lee, Yang, Jeong, Kim, Lee, Kim, Hajjar, Park: Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy. in Journal of molecular and cellular cardiology 2012
Show all 2 Pubmed References
our analyses uncover essential roles of Six1 in hair cell differentiation and formation of the organ of Corti in the mammalian cochlea
SIX1 regulates dorsal arch development not only by inducing dorsal Jag1 (show JAG1 Antibodies) expression but also by inhibiting endothelin 1 (Edn1 (show EDN1 Antibodies)) expression in the pharyngeal endoderm of the dorsal arch, thus preventing dorsal EDNRA (show EDNRA Antibodies) signaling.
significant co-localization of binding sites for MyoD (show MYOD1 Antibodies) and Six proteins on over a thousand mouse genomic DNA regions, were found.
we show that SIX1 binds to adipogenic and brown marker genes and interacts with C/EBPa (show CEBPA Antibodies), C/EBPb (show CEBPB Antibodies) and EBF2 (show EBF2 Antibodies), suggesting their functional cooperation during adipogenesis.
Studies strongly suggest that Six1 overexpression promotes CRC (show SCRIB Antibodies) growth and metastasis and remodels tumor stroma by stimulating angiogenesis and recruiting TAM (show CCNA1 Antibodies). MAPK (show MAPK1 Antibodies) activation may be a pivotal event in Six1-associated tumor progression.
Downregulation of Six1 effectively inhibited airway inflammation and reversed airway remodeling, which suggest that Six1 represents a promising therapeutic strategy for human allergic asthma.
results suggest that SIX1 is a key proliferation regulator in mouse DFCs and human PDLCs, which provides novel insight into Six family gene function in mammals.
Our findings imply that SIX1 may play a role as an important regulator to orchestrate the dynamic of uterine endometrium in response to estrogen level during the estrous cycle.
Activation of Six1 Expression in Vertebrate Sensory Neurons.
Six1 knockdown caused a fast-to-slow shift in myosin heavy chain isoform
SIX1 oncoprotein is aberrantly expressed in the endometrium following developmental exposure to estrogenic chemicals, correlates with uterine cancer, and is a biomarker in human endometrial cancers
SIX homeobox 1 (SIX1) regulates cellular senescence by a p16INK4A (p16 (show CDKN2A Antibodies))-dependent mechanism.
PTH2R (show PTH2R Antibodies) and its ligand TIP39 (show TFIP11 Antibodies) regulate intracellular calcium and influence keratinocyte differentiation
Studies strongly suggest that Six1 overexpression promotes CRC (show CALR Antibodies) growth and metastasis and remodels tumor stroma by stimulating angiogenesis and recruiting TAM (show CCNA1 Antibodies). MAPK (show MAPK1 Antibodies) activation may be a pivotal event in Six1-associated tumor progression.
Restoration of SIX1 was sufficient to abolish proliferation, migration and invasion induced by miR (show MLXIP Antibodies)-362 overexpression in cervical cancer cells. The newly identified miR (show MLXIP Antibodies)-362/SIX1 pathway provides insight into cervical cancer progression, and may represent a novel therapeutic target.
study replicated the association of POAG with two SNPs at the SIX1-SIX6 (show SIX6 Antibodies) locus and demonstrated that SNPs, rs10483727 and rs33912345, are significantly associated with POAG, especially with NTG (show OPA1 Antibodies) in patients aged above 40 years
miR (show MLXIP Antibodies)-188 suppresses proliferation and invasion by targeting SIX1 in oral squamous cell carcinoma cells.
Pro-survival effects by NF-kappaB (show NFKB1 Antibodies), Akt (show AKT1 Antibodies) and ERK(1 (show MAPK3 Antibodies)/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4 (show HLADRB4 Antibodies)/5 pathway in ovarian cancer, which may explain why up-regulated DR4 (show HLADRB4 Antibodies) and DR5 (show TNFRSF10B Antibodies) in ovarian cancer are associated with poor prognosis and low survival ratio of the patients.
Upregulation of Six1 could downregulate miR (show MLXIP Antibodies)-204-5p expression.
The HD domain is important for the nuclear localization of porcine Six1 protein.
these findings establish an interaction between Pa2G4 (show PA2G4 Antibodies) and Six1, and demonstrate that it has an important role in the development of tissues affected in Branchiootorenal Spectrum disorder.
Microarray identification of novel genes downstream of Six1, a critical factor in cranial placode, somite, and kidney development.
The results indicated the critical role of Six1 in transition of Rohon-Beard cells to dorsal root ganglia (DRG) neurons during Xenopus development and establishment of exclusive DRG system of mice.
Eya1 (show EYA1 Antibodies) and Six1 are required for both the regulation of placodal neuronal progenitor proliferation, through their effects on SoxB1 expression, and subsequent neuronal differentiation.
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3).
homeobox protein SIX1
, sine oculis homeobox homolog 1
, sine oculis-related homeobox 1 homolog
, Sine oculis homeobox homolog 1
, homeobox protein six1