Browse our SLC12A2 Proteins (SLC12A2)

Full name:
Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 2 Proteins (SLC12A2)
On are 9 Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 2 (SLC12A2) Proteins from 2 different suppliers available. Additionally we are shipping SLC12A2 Antibodies (97) and SLC12A2 Kits (2) and many more products for this protein. A total of 114 SLC12A2 products are currently listed.
9330166H04Rik, BSC, bsc2, mBSC2, Nkcc1, sy-ns
list all proteins Gene Name GeneID UniProt
SLC12A2 6558 P55011
Rat SLC12A2 SLC12A2 83629  
SLC12A2 20496 P55012

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SLC12A2 Proteins (SLC12A2) by Origin

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More Proteins for SLC12A2 Interaction Partners

Human Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 2 (SLC12A2) interaction partners

  1. we introduce the molecular mechanism by which flavonoids, specifically quercetin, act through elevation of [Cl(-) ]c via activation of NKCC1 on important factors controlling various body and cellular functions, such as (1) antihypertensive actions controlling blood volume dependent on the amounts of renal Na(+) reabsorption via expression of the epithelial Na(+) channel

  2. NKCC1 and KCCs are coordinately regulated by L-WNK1 (show WNK1 Proteins) isoforms.

  3. We also discovered and replicated three genome-wide significant variants in previously unreported loci for RDW (SLC12A2 rs17764730, PSMB5 (show PSMB5 Proteins) rs941718), and hematocrit (PROX1 (show PROX1 Proteins) rs3754140) and an upstream anti-sense long-noncoding RNA, LINC01184, as the likely causal variant

  4. NKCC1 high expression predicted a bad clinical outcome for lung adenocarcinoma patients and EGFR (show EGFR Proteins)-mutated subgroup. Therefore, NKCC1 may play a role in lung adenocarcinoma and novel therapeutic tactics could be developed by targeting NKCC1 protein.

  5. Study describes a functional missense variant in SLC12A2 in human schizophrenia, and suggest that genetically encoded dysregulation of NKCC1 may be a risk factor for, or contribute to the pathogenesis of, schizophrenia

  6. The NKCC-1 is a Na(+)- dependent Cl(-) transporter that mediates the movement of Na(+), K(+), and Cl(-) ions across the plasma membrane and maintains cell volume and intracellular K(+) and Cl(-) homeostasis.

  7. NKCC1 labeling was seen only in the basolateral membrane of the secretory coils.

  8. Suggest that the expression of NKCC1 in esophageal squamous cell carcinoma may affect the G2/M checkpoint and may be related to the degree of histological differentiation of SCCs.

  9. Functional expression of human NKCC1 from a synthetic cassette-based cDNA: introduction of extracellular epitope tags and removal of cysteines.

  10. our data show a novel role for the WNK1 (show WNK1 Proteins)/OSR1 (show OXSR1 Proteins)/NKCC1 pathway in glioma migration

Mouse (Murine) Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 2 (SLC12A2) interaction partners

  1. Study suggests that astaxanthin may exert neuroprotection following traumatic brain injury by ameliorating AQP4 (show AQP4 Proteins)/NKCC1-mediated cerebral edema, and NKCC1 inactivation inhibitions the upregulation of AQP4 (show AQP4 Proteins) after traumatic brain injury.

  2. GABAA (show GABRg1 Proteins) receptor (GABAAR (show GABRG2 Proteins)) and the Na(+)-K(+)-2Cl(-) cotransporter (show SLC12A1 Proteins) (NKCC1), but not the K(+)-Cl(-) cotransporter (show SLC12A4 Proteins) (KCC2 (show SLC12A5 Proteins)), were expressed in the terminals of the CRH (show CRH Proteins) neurons at the median eminence (ME). In contrast, CRH (show CRH Proteins) neuronal somata were enriched with KCC2 (show SLC12A5 Proteins) but not with NKCC1.

  3. These results identify NKCC1 as a novel target for Nedd4L (show NEDD4L Proteins)-mediated down-regulation in vivo, which modulates ion and fluid transport in the distal colon together with epithelial Na(+) channel (ENaC (show SCNN1A Proteins)).

  4. NKCC1 inhibition protects neurons from traumatic brain injury via regulation of the ERK (show EPHB2 Proteins) signal pathway.

  5. We conclude that TRPV2 (show TRPV2 Proteins) is involved in osmosensation in skeletal muscle fibres, acting in concert with P-SPAK (show STK39 Proteins)-activated NKCC1

  6. KCC2 (show SLC12A5 Proteins) expression supersedes NKCC1 in mature fiber cells in mouse and rabbit lenses.

  7. GnRH (show GNRH1 Proteins) neurons were immunopositive for NKCC1 and AE2 (show SLC4A2 Proteins).

  8. NKCC1 may have a role in periventricular leukomalacia, as shown by bumetanide protection against white matter injury in a rodent model

  9. our results suggest that NKCCs are involved in insulin (show INS Proteins) secretion and that a single Slc12a2 allele may protect beta-cells from failure due to increased homeostatic expression of Slc12a1 (show SLC12A1 Proteins).

  10. Repeated stress decreased KCC2 (show SLC12A5 Proteins) expression and increased NKCC1 expression in membranes of granular and pyramidal cells in the hippocampus.

SLC12A2 Protein Profile

Protein Summary

The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with SLC12A2

  • solute carrier family 12 (sodium/potassium/chloride transporters), member 2 (SLC12A2)
  • solute carrier family 12 (sodium/potassium/chloride transporter), member 2 (SLC12A2)
  • solute carrier family 12 (sodium/potassium/chloride transporter), member 2 (Slc12a2)
  • solute carrier family 12, member 2 (Slc12a2)
  • 9330166H04Rik protein
  • BSC protein
  • bsc2 protein
  • mBSC2 protein
  • Nkcc1 protein
  • sy-ns protein

Protein level used designations for SLC12A2

solute carrier family 12 (sodium/potassium/chloride transporters), member 2 , solute carrier family 12 member 2-like , basolateral Na-K-Cl symporter , bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1 , solute carrier family 12 member 2 , solute carrier family 12, member 2 , basolateral NaK(2Cl) cotransporter , sodium/potassium/chloride cotransporters , sodium/potassium/chloride transporters

100464321 Ailuropoda melanoleuca
6558 Homo sapiens
83629 Rattus norvegicus
286845 Bos taurus
481490 Canis lupus familiaris
20496 Mus musculus
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