You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our SLC12A2 Proteins (SLC12A2)

Full name:
Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 2 Proteins (SLC12A2)
On are 9 Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 2 (SLC12A2) Proteins from 2 different suppliers available. Additionally we are shipping SLC12A2 Antibodies (89) and SLC12A2 Kits (2) and many more products for this protein. A total of 105 SLC12A2 products are currently listed.
9330166H04Rik, BSC, bsc2, mBSC2, Nkcc1, sy-ns
list all proteins Gene Name GeneID UniProt
SLC12A2 6558 P55011
Rat SLC12A2 SLC12A2 83629  
SLC12A2 20496 P55012

Show all synonyms

SLC12A2 Proteins (SLC12A2) by Origin

Select your origin of interest

More Proteins for SLC12A2 Interaction Partners

Human Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 2 (SLC12A2) interaction partners

  1. NKCC1 high expression predicted a bad clinical outcome for lung adenocarcinoma patients and EGFR (show EGFR Proteins)-mutated subgroup. Therefore, NKCC1 may play a role in lung adenocarcinoma and novel therapeutic tactics could be developed by targeting NKCC1 protein.

  2. Study describes a functional missense variant in SLC12A2 in human schizophrenia, and suggest that genetically encoded dysregulation of NKCC1 may be a risk factor for, or contribute to the pathogenesis of, schizophrenia

  3. The NKCC-1 is a Na(+)- dependent Cl(-) transporter that mediates the movement of Na(+), K(+), and Cl(-) ions across the plasma membrane and maintains cell volume and intracellular K(+) and Cl(-) homeostasis.

  4. NKCC1 labeling was seen only in the basolateral membrane of the secretory coils.

  5. Suggest that the expression of NKCC1 in esophageal squamous cell carcinoma may affect the G2/M checkpoint and may be related to the degree of histological differentiation of SCCs.

  6. Functional expression of human NKCC1 from a synthetic cassette-based cDNA: introduction of extracellular epitope tags and removal of cysteines.

  7. our data show a novel role for the WNK1 (show WNK1 Proteins)/OSR1 (show OXSR1 Proteins)/NKCC1 pathway in glioma migration

  8. Reduced KCC2 (show SLC12A5 Proteins)/NKCC1 ratio in the cerebrospinal fluid of Rett Syndrome patients suggests a disturbed process of GABAergic neuronal maturation and open up a new therapeutic perspective.

  9. The hormone aldosterone was found to upregulate NKCC1 by increasing protein stability.

  10. Altered hippocampal area function and coupling in DISC1 (show DISC1 Proteins) and SLC12A2 minor allele carriers.

Mouse (Murine) Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 2 (SLC12A2) interaction partners

  1. NKCC1 inhibition protects neurons from traumatic brain injury via regulation of the ERK (show EPHB2 Proteins) signal pathway.

  2. We conclude that TRPV2 (show TRPV2 Proteins) is involved in osmosensation in skeletal muscle fibres, acting in concert with P-SPAK (show STK39 Proteins)-activated NKCC1

  3. KCC2 (show SLC12A5 Proteins) expression supersedes NKCC1 in mature fiber cells in mouse and rabbit lenses.

  4. GnRH (show GNRH1 Proteins) neurons were immunopositive for NKCC1 and AE2 (show SLC4A2 Proteins).

  5. NKCC1 may have a role in periventricular leukomalacia, as shown by bumetanide protection against white matter injury in a rodent model

  6. our results suggest that NKCCs are involved in insulin (show INS Proteins) secretion and that a single Slc12a2 allele may protect beta-cells from failure due to increased homeostatic expression of Slc12a1 (show SLC12A1 Proteins).

  7. Repeated stress decreased KCC2 (show SLC12A5 Proteins) expression and increased NKCC1 expression in membranes of granular and pyramidal cells in the hippocampus.

  8. Data indicate that ion transporter NKCC1 is involved in chloride accumulation but also reveals an impact in neurogenesis.

  9. NKCC1 appeared down regulated in age related hearing loss.

  10. The FAK (show PTK2 Proteins) inhibitor PF-573,228 augmented shrinkage-induced Src (show SRC Proteins) phosphorylation, and inhibited shrinkage-induced NKCC1 activity.

SLC12A2 Protein Profile

Protein Summary

The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with SLC12A2

  • solute carrier family 12 (sodium/potassium/chloride transporters), member 2 (SLC12A2)
  • solute carrier family 12 (sodium/potassium/chloride transporter), member 2 (SLC12A2)
  • solute carrier family 12 (sodium/potassium/chloride transporter), member 2 (Slc12a2)
  • solute carrier family 12, member 2 (Slc12a2)
  • 9330166H04Rik protein
  • BSC protein
  • bsc2 protein
  • mBSC2 protein
  • Nkcc1 protein
  • sy-ns protein

Protein level used designations for SLC12A2

solute carrier family 12 (sodium/potassium/chloride transporters), member 2 , solute carrier family 12 member 2-like , basolateral Na-K-Cl symporter , bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1 , solute carrier family 12 member 2 , solute carrier family 12, member 2 , basolateral NaK(2Cl) cotransporter , sodium/potassium/chloride cotransporters , sodium/potassium/chloride transporters

100464321 Ailuropoda melanoleuca
6558 Homo sapiens
83629 Rattus norvegicus
286845 Bos taurus
481490 Canis lupus familiaris
20496 Mus musculus
Selected quality suppliers for SLC12A2 Proteins (SLC12A2)
Did you look for something else?