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Superoxide Dismutase 2, Mitochondrial Proteins (SOD2)
On are 47 Superoxide Dismutase 2, Mitochondrial (SOD2) Proteins from 13 different suppliers available. Additionally we are shipping Superoxide Dismutase 2, Mitochondrial Antibodies (277) and Superoxide Dismutase 2, Mitochondrial Kits (47) and many more products for this protein. A total of 380 Superoxide Dismutase 2, Mitochondrial products are currently listed.
cb463, CG8905, Dmel\\CG8905, dSOD2, GB14346, IPOB, LOC100101896, MGC88869, Mito SOD, mitSOD2, Mn-SOD, Mn-SOD2, mnSOD, Mn SOD, MnSODII, Mn[2+]SOD, MVCD6, SOD, Sod-2, SOD2, wu:fj33b01, zgc:73051
list all proteins Gene Name GeneID UniProt
SOD2 6648 P04179
SOD2 20656 P09671
SOD2 24787 P07895

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Superoxide Dismutase 2, Mitochondrial Proteins (SOD2) by Origin

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Top referenced Superoxide Dismutase 2, Mitochondrial Proteins

  1. Rat (Rattus) SOD2 Protein expressed in Escherichia coli (E. coli) - ABIN1686709 : Adachi, Ohta, Yamada, Futenma, Kato, Hirano: Quantitative analysis of extracellular-superoxide dismutase in serum and urine by ELISA with monoclonal antibody. in Clinica chimica acta; international journal of clinical chemistry 1993 (PubMed)
    Show all 2 references for ABIN1686709

  2. Human SOD2 Protein expressed in Escherichia coli (E. coli) - ABIN666966 : MacMillan-Crow, Thompson: Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite. in Archives of biochemistry and biophysics 1999 (PubMed)
    Show all 2 references for ABIN666966

  3. Human SOD2 Protein expressed in Escherichia coli (E. coli) - ABIN1686712 : Wispé, Clark, Burhans, Kropp, Korfhagen, Whitsett: Synthesis and processing of the precursor for human mangano-superoxide dismutase. in Biochimica et biophysica acta 1989 (PubMed)
    Show all 2 references for ABIN1686712

  4. Human SOD2 Protein expressed in Wheat germ - ABIN1320944 : Yang, Xiao, Zhang, Li, Zhang, Li, Chen, Zhu, Sun, Liu, Chen: Identification of tumor antigens in human lung squamous carcinoma by serological proteome analysis. in Journal of proteome research 2007 (PubMed)

More Proteins for Superoxide Dismutase 2, Mitochondrial Interaction Partners

Rabbit Superoxide Dismutase 2, Mitochondrial (SOD2) interaction partners

  1. Prion (show PRNP Proteins) propagation exacerbates an apoptotic pathway whereby mitochondrial dysfunction follows mislocalisation of SOD2 to cytosolic caspases permitting its degradation.

Fruit Fly (Drosophila melanogaster) Superoxide Dismutase 2, Mitochondrial (SOD2) interaction partners

  1. Depletion of superoxide dismutases promotes muscular and neuronal ROS (show ROS1 Proteins) accumulation which may have a significant effect on age-dependent impairment of the Drosophila adults.

  2. Paraquat exposure, but not Sod2 knockdown, resulted in increased carbonylated protein relative abundance.

  3. The functional SOD1 (show SOD1 Proteins) and SOD2 genes knockout and their overexpression in neurons and glial tissue increase the sensitivity of Drosophila melanogaster to oxidative stress conditions.

  4. ocytes lacking maternal SOD2 protein develop into adults just like normal SOD2-containing oocytes suggesting that maternal SOD2-mediated protection against mitochondrial ROS (show ROS1 Proteins) is not essential for oocyte viability

  5. Muscles appear to be more sensitive to superoxide attack relative to the neurons and such overt phenotypes observed in SOD2-deficient animals can be directly attributed to the muscle.

  6. Overexpression of Cu,ZnSOD (show SOD1 Proteins) and MnSOD in transgenic Drosophila.

  7. Ablation of mitochondrial SOD2 through expression of a GAL4 (show LGALS4 Proteins)-regulated, inverted-repeat Sod2 RNA-interference causes increased endogenous oxidative stress, loss of respiratory chain & TCA cycle components,& early-onset mortality in young adults.

  8. Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity.

  9. The chromosomal deficiency Df(2R)017 significantly up-regulated MnSOD mRNA by 1.7-fold. Deficiency in four other genomic intervals, Df(1)ct-J4, Df(2L)BSC4, Df(3L)66C-G28 and Df(3R)Scr, down-regulated MnSOD expression.

  10. SOD1 (show SOD1 Proteins) and SOD2 provide independent protection to compartment-specific protein iron-sulfur clusters against attack by superoxide generated under oxidative stress

Human Superoxide Dismutase 2, Mitochondrial (SOD2) interaction partners

  1. These results suggest SOD2 as a newly identified gene conferring susceptibility to leprosy.

  2. Results suggest that MnSOD Val(16)Ala single-nucleotide polymorphism may not contribute to lung cancer susceptibility.

  3. meta-analysis suggested that SOD2 C47T polymorphism is significantly associated with an increased risk of noise-induced hearing loss in the Chinese population.

  4. Study demonstrates that SOD2 rs4880, GPX1 (show GPX1 Proteins) rs1050450 and CAT rs1001179 are not associated with an increased susceptibility to epilepsy after neonatal hypoxic-ischemic encephalopathyor its drug resistance

  5. The antioxidative effects of the Mediterranean diet against breast cancer risk may be enhanced by the wild-type alleles of the MnSOD or CAT SNPs among Greek-Cypriot women.

  6. Lower SOD2 protein content in mononuclear cells Is associated with improved survival in chronic kidney disease patients undergoing hemodialysis therapy.

  7. we identify miR (show MLXIP Proteins)-146a as a potential tumor suppressor in patients with EOC. miR (show MLXIP Proteins)-146a downregulates the expression of SOD2 and enhances ROS (show ROS1 Proteins) generation, leading to increased apoptosis, inhibition of proliferation, and enhanced sensitivity to chemotherapy.

  8. Data show that antioxidant enzymes SOD2 and GPX1 (show GPX1 Proteins) expression and GPX1 (show GPX1 Proteins) and SOD1 (show SOD1 Proteins) activity were significantly higher in patients at diagnosis of bladder cancer (BC) in comparison to controls.

  9. The effects of hypericin and methoxyestradiol on the expression of SOD2 in MCF-7 cells and the sensitivity of these cells to photodynamic therapy are reported.

  10. Mn-SOD overexpression is a common event in colorectal cancer

Pig (Porcine) Superoxide Dismutase 2, Mitochondrial (SOD2) interaction partners

  1. show that ischemia markedly potentiated the expression of arginase-1 (show ARG1 Proteins), and also induced the SOD2 in the wound tissue.

Cow (Bovine) Superoxide Dismutase 2, Mitochondrial (SOD2) interaction partners

  1. Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2, GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1 (show NR3C1 Proteins). TNF (show TNF Proteins) and IL6 (show IL6 Proteins) levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.

  2. Data suggest that during ectogenesis of blastocysts infected with bovine Herpesvirus type 5, expression of SOD2 (Mn) remains high indicating intense mitochondrial activity; this effect may be involved in inhibition of apoptosis in infected embryos.

  3. expression profile of SOD2 in follicles: oocytes (SOD2 restricted to ooplasm); cumulus cells (expressed some SOD2); follicular fluid (small follicles show increased amounts of SOD2 in comparison with large follicles)

  4. Shear stress influences spatial variations in vascular Mn-SOD expression with implications for LDL nitration.

  5. The expression of SOD1 (show SOD1 Proteins) and SOD2 through the course of the estrous cycle is reported.

  6. Heart mitochondrial nucleoids contained SOD2, aortic endothelial cell mitochondrial nucleoids did not

Mouse (Murine) Superoxide Dismutase 2, Mitochondrial (SOD2) interaction partners

  1. Thus, a ROS (show ROS1 Proteins)-dependent epigenetic positive regulation of Sod2 gene expression likely represents a defense mechanism prolonging eNOS (show NOS3 Proteins) function in aging mouse femoral arteries.

  2. In this review, we will conglomerate the current aspects by which MnSOD can contribute to embryonic stem cells' and adult stem cells' functions and interpret the necessity of understanding MnSOD for further stem cell mediated applications

  3. The results indicated that the inconsistency between Mn SOD expression and its activity might contribute to the development of recognition dysfunction induced by chronic Al overload.

  4. Evidence for a tumor suppressive role of MnSOD in liver, where the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) and hypoxia pathway may be crucial elements.

  5. SOD2 overexpression in cardiomyocytes enhances mitochondrial function and metabolic vasodilation, leading to a phenotype of supernormal cardiac function.

  6. Pluripotency transcription factors Nanog (show NANOG Proteins) and Oct4 (show POU5F1 Proteins) positively modulate Sod2 gene transcription in induced pluripotent stem cells.

  7. Data show that mechanical overloading elevated mitochondrial superoxide generation and downregulated superoxide dismutase 2 (Sod2) expression in knee chondrocytes.

  8. Data show that tissue specific deletion of manganese superoxide dismutase (Sod2) caused elevated signs of oxidative stress, retinal pigment epithelium (RPE (show RPE Proteins)) dysfunction and showed some key features of age-related macular degeneration (AMD (show AMD1 Proteins)). .

  9. Mutated myocilin (show MYOC Proteins) and heterozygous Sod2 deficiency act synergistically in a mouse model of open-angle glaucoma

  10. Data indicate sirtuin 3 (Sirt3 (show SIRT3 Proteins))-manganese superoxide dismutase (MnSOD) axis as a negative component in nicotine-induced mitochondrial oxidative stress and mitochondrial DNA (mtDNA) damage.

Superoxide Dismutase 2, Mitochondrial (SOD2) Protein Profile

Protein Summary

This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with Superoxide Dismutase 2, Mitochondrial (SOD2)

  • MnSOD (BDBG_07234)
  • MnSOD (LOC100101896)
  • manganese superoxide dismutase (GSVIVT00029451001)
  • superoxide dismutase 2, mitochondrial (Sod2)
  • superoxide dismutase 2, mitochondrial (sod2)
  • Mn superoxide dismutase (Sod2)
  • Mn superoxide dismutase (LbMnSOD4)
  • superoxide dismutase 2, mitochondrial (SOD2)
  • superoxide dismutase 2 (LOC100282741)
  • manganese superoxide dismutase (SOD-2)
  • Superoxide dismutase 2 (Mn) (Sod2)
  • cb463 protein
  • CG8905 protein
  • Dmel\\CG8905 protein
  • dSOD2 protein
  • GB14346 protein
  • IPOB protein
  • LOC100101896 protein
  • MGC88869 protein
  • Mito SOD protein
  • mitSOD2 protein
  • Mn-SOD protein
  • Mn-SOD2 protein
  • mnSOD protein
  • Mn SOD protein
  • MnSODII protein
  • Mn[2+]SOD protein
  • MVCD6 protein
  • SOD protein
  • Sod-2 protein
  • SOD2 protein
  • wu:fj33b01 protein
  • zgc:73051 protein

Protein level used designations for SOD2

MnSOD , manganese superoxide dismutase , Mn Sod , Mn superoxide dismutase , superoxide dismutase 2, mitochondrial , superoxide dismutase [Mn], mitochondrial , GRMZM5G891739 , CG8905-PA , Mn-superoxide dismutase , Sod2-PA , manganese-SOD , mitochodnrial SOD , mitochondrial Mn-superoxide dismutase 2 , mitochondrial MnSOD , mitochondrial superoxide dismutase 2 , superoxide dismutase , superoxide dismutase 2 , superoxide dismutase 2 (Mn) , superoxide dismutase-2 , indophenoloxidase B , manganese-containing superoxide dismutase , mangano-superoxide dismutase , superoxide dismutase (Mn type) , manganous superoxide dismutase , manganese SOD , Superoxide dimutase 2, mitochondrial , Mn-SOD , sod(Mn)

8502558 Ajellomyces dermatitidis SLH14081
100101896 Glycine max
100233137 Vitis vinifera
410082 Apis mellifera
448200 Xenopus (Silurana) tropicalis
692736 Bombyx mori
6074587 Laccaria bicolor S238N-H82
100174061 Pongo abelii
100282741 Zea mays
100009336 Oryctolagus cuniculus
36878 Drosophila melanogaster
6648 Homo sapiens
399216 Xenopus laevis
374042 Gallus gallus
476258 Canis lupus familiaris
100154319 Sus scrofa
281496 Bos taurus
780457 Ovis aries
20656 Mus musculus
24787 Rattus norvegicus
100135623 Cavia porcellus
335799 Danio rerio
574097 Macaca mulatta
449634 Pan troglodytes
100410185 Callithrix jacchus
100034223 Equus caballus
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