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Data indicate that human T-box 18 (TBX18) gene induces rat adipose-derived stem cells (ADSCs) to differentiate into pacemaker-like cells in the cardiac microenvironment.
Mutations in TBX18 cause dominant urinary tract malformations via transcriptional dysregulation of ureter development.
The DNA sequence variants within the TBX18 gene promoter identified in ventricular septal defects (VSD) patients may be involved in the VSD etiology.
connexin43 (show GJA1 ELISA Kits) transcriptional suppression by TBX18 undermines cardiomyocyte cell-cell electrical coupling
Tbx18 interacts with Gata4 (show GATA4 ELISA Kits) and Nkx2-5 (show NKX2-5 ELISA Kits) and competes Tbx5 (show TBX5 ELISA Kits)-mediated activation of the cardiac Natriuretic peptide precursor type a-promoter. Tbx18 down-regulates Tbx6 (show TBX6 ELISA Kits)-activated Delta-like 1 (show DLL1 ELISA Kits) expression in the somitic mesoderm in vivo
Areas of strong tbx18 expression are found in the developing somitic and presomitic mesoderm, in the heart and in pectoral fin mesenchyme, as well as the ventral neuroectoderm and the developing palate
Tbx18 is essential to the differentiation and maintenance of the prostate periurethral mesenchyme; it indirectly regulates epithelial differentiation through control of stromal-epithelial signaling.
The temporal suppression of Tbx18 gene expression by the hypermethylation of its promoter seems to trigger the differentiation of mesenchymal cells into hypertrophic chondrocytes in the early stages of endochondral ossification.
A distant downstream enhancer directs essential expression of Tbx18 in urogenital tissues.
Tbx18 has a role in normal development of vasculature network and glomerular mesangium in the mammalian kidney
Tbx18, a T-box family member highly expressed in the proepicardium, controls critical early steps in coronary development.
Tbx18 is required to prepattern mouse ureteric mesenchyme
Tbx18 and Wt1 (show WT1 ELISA Kits) directly bound to the Slug (show SNAI2 ELISA Kits) promoter region and regulated Slug (show SNAI2 ELISA Kits) expression
Tbx18 is dispensable for epicardial development but that a transcriptional activator form of Tbx18 is sufficient to induce premature smooth muscle differentiation of epicardial cells.
Tbx18 is dispensable for normal dermal papilla function.
Data show that Tbx18- and Wt1 (show WT1 ELISA Kits)-deficient mice additionally exhibit partial pericardial absence.
This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors.
, T-box transcription factor TBX18-like
, t-box transcription factor TBX18-like
, T-box transcription factor TBX18
, transcription factor Tbx18
, T-box protein 18