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When HEK293T cells were co-transfected with IQGAP1 and VCP (show vcp ELISA Kits), an immunoprecipitation assay revealed that binding of IQGAP1 with disease-related mutant (R155H or A232E) VCP (show vcp ELISA Kits) was markedly reduced compared to wild-type VCP (show vcp ELISA Kits). This suggests that reduction of IQGAP1 and VCP (show vcp ELISA Kits) interaction may be associated with the pathophysiology of inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD (show vcp ELISA Kits)).
the results show that IQGAP1 is a novel regulator of type I IFN production, possibly via interacting with NLRC3 (show NLRC3 ELISA Kits) in human monocytic and epithelial cells
The structural basis for Cdc42 (show CDC42 ELISA Kits)-induced dimerization of IQGAP1 and IQGAP2 (show IQGAP2 ELISA Kits) has been uncovered.
The LGR5 primarily functions via the IQGAP1-Rac1 pathway to strengthen cell-cell adhesion in normal adult crypt stem cells and colon cancer cells.
findings suggest a novel role of IQGAP1 in insulin (show INS ELISA Kits)-regulated interaction between caveolae and cytoskeletal elements of the adipocyte, and that this is quelled in the diabetic state
Alterated IQGAP1/Rho GTPase (show RACGAP1 ELISA Kits) signaling in myeloproliferative neoplasm erythrocytes is dependent on JAK2 (show JAK2 ELISA Kits)/CALR (show CALR ELISA Kits) mutational status.
our data suggest that IQ-domain GTPase-activating protein (show RASA1 ELISA Kits) 1 may promote the malignant phenotype of invasive ductal carcinoma via canonical Wnt (show WNT2 ELISA Kits) signaling, and it could be used as a potential prognostic biomarker for breast cancer patients.
IQ domain of IQGAP1 is both necessary and sufficient for binding to ERK1 (show MAPK3 ELISA Kits) and ERK2 (show MAPK1 ELISA Kits), as well as to the MAPK (show MAPK1 ELISA Kits) kinases MEK1 (show MAP2K1 ELISA Kits) and MEK2 (show MAP2K2 ELISA Kits).
Data indicate that the IQGAP1 N-terminal fragment spanning residues 1-191 (CHDF) binds to both F-actin and Ca(2 (show CA2 ELISA Kits)+)/calmodulin (show CALM1 ELISA Kits).
These data were confirmed by phosphomimetic mutation of serine 1443 to glutamate within RGCT, which led to a significant reduction of IQGAP1 affinity for CDC42 and RAC1, clearly disclosing the critical role of RGCT for these interactions.
Data highlight a unique mechanism of formin (show FMN1 ELISA Kits) action in which mDia1 and INF2 (show INF2 ELISA Kits) function in series to stabilize MTs (show NEU2 ELISA Kits) and point to IQGAP1 as a scaffold that facilitates the activation of one formin (show FMN1 ELISA Kits) by another.
Hectd1 regulates the protein level of IQGAP1 through ubiquitination.
Loss of IQGAP1 results in impaired insulin (show INS ELISA Kits) signaling and glucose homeostasis in vivo.
These data reveal that IQGAP1 binds to YAP (show YAP1 ELISA Kits) and modulates its co-transcriptional function, suggesting that IQGAP1 participates in Hippo signaling.
IQGAP1 has a strong signaling relationship with Ras genes in induction of cancer and it is considered as a key gene for induction or suppression of the hepatocellular carcinoma.
IQGAP1 has the potential to modulate airway contraction severity in acute asthma.
we propose that IQGAP1 acts as a small GTPase (show RACGAP1 ELISA Kits) scaffolding platform within the small GTPase (show RACGAP1 ELISA Kits) network, and recruits and/or regulates small GTPases, small GTPase (show RACGAP1 ELISA Kits) regulators and effectors to orchestrate cell behavior
This finding has new implications for involvement of IQGAP1 in cell polarization and migration events and potentially in cell cycle-associated nuclear envelope assembly/disassembly.
IQGAP1 contributes to AngII-induced apoptosis of podocytes by interacting with the ERK1/2 (show MAPK1/3 ELISA Kits) signaling protein
RSPO (show RSPO1 ELISA Kits)-LGR4 (show LGR4 ELISA Kits) not only induces the clearance of RNF43 (show RNF43 ELISA Kits)/ZNRF3 to increase Wnt receptor levels but also recruits IQGAP1 into the Wnt (show WNT2 ELISA Kits) signaling complex.
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.
RasGAP-like with IQ motifs
, ras GTPase-activating-like protein IQGAP1
, Cdc42-Rac1 effector protein