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our data suggest that IQ-domain GTPase-activating protein (show RASA1 ELISA Kits) 1 may promote the malignant phenotype of invasive ductal carcinoma via canonical Wnt (show WNT2 ELISA Kits) signaling, and it could be used as a potential prognostic biomarker for breast cancer patients.
IQ domain of IQGAP1 is both necessary and sufficient for binding to ERK1 (show MAPK3 ELISA Kits) and ERK2 (show MAPK1 ELISA Kits), as well as to the MAPK (show MAPK1 ELISA Kits) kinases MEK1 (show MAP2K1 ELISA Kits) and MEK2 (show MAP2K2 ELISA Kits).
Data indicate that the IQGAP1 N-terminal fragment spanning residues 1-191 (CHDF) binds to both F-actin and Ca(2 (show CA2 ELISA Kits)+)/calmodulin (show CALM1 ELISA Kits).
These data were confirmed by phosphomimetic mutation of serine 1443 to glutamate within RGCT, which led to a significant reduction of IQGAP1 affinity for CDC42 and RAC1, clearly disclosing the critical role of RGCT for these interactions.
These data reveal that IQGAP1 binds to YAP (show YAP1 ELISA Kits) and modulates its co-transcriptional function, suggesting that IQGAP1 participates in Hippo signaling.
The results indicated that IQGAP1 was expressed at higher levels in glioma tissues compared with in normal brain tissues. IQGAP1siRNA significantly inhibited cell proliferation, and cell adhesion, migration and invasion.
IQGAP1 protein is involved in normal cell physiology as well as oncologic processes.
after AKT-mediated phosphorylation at serine 319, FOXO1 binds to IQGAP1, a hub for activation of the MAPK pathway, and impedes IQGAP1-dependent phosphorylation of ERK1/2 (pERK1/2).
High expression of IQGAP1 is associated with glioma.
High IQGAP1 expression is associated with hepatocellular carcinoma.
Hectd1 regulates the protein level of IQGAP1 through ubiquitination.
Loss of IQGAP1 results in impaired insulin (show INS ELISA Kits) signaling and glucose homeostasis in vivo.
IQGAP1 has a strong signaling relationship with Ras genes in induction of cancer and it is considered as a key gene for induction or suppression of the hepatocellular carcinoma.
IQGAP1 has the potential to modulate airway contraction severity in acute asthma.
we propose that IQGAP1 acts as a small GTPase (show RACGAP1 ELISA Kits) scaffolding platform within the small GTPase (show RACGAP1 ELISA Kits) network, and recruits and/or regulates small GTPases, small GTPase (show RACGAP1 ELISA Kits) regulators and effectors to orchestrate cell behavior
This finding has new implications for involvement of IQGAP1 in cell polarization and migration events and potentially in cell cycle-associated nuclear envelope assembly/disassembly.
IQGAP1 contributes to AngII-induced apoptosis of podocytes by interacting with the ERK1/2 (show MAPK1/3 ELISA Kits) signaling protein
RSPO (show RSPO1 ELISA Kits)-LGR4 (show LGR4 ELISA Kits) not only induces the clearance of RNF43 (show RNF43 ELISA Kits)/ZNRF3 to increase Wnt receptor levels but also recruits IQGAP1 into the Wnt (show WNT2 ELISA Kits) signaling complex.
IQGAP1 is upregulated in pre-existed sparing neurons of the CA1 (show CA1 ELISA Kits) layer undergoing morphological changes after excitoxicity-induced hippocampal CA3 (show CA3 ELISA Kits) neuronal death.
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.
RasGAP-like with IQ motifs
, ras GTPase-activating-like protein IQGAP1
, Cdc42-Rac1 effector protein