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Sphingosine-1-Phosphate Receptor 1 Proteins (S1PR1)
On www.antibodies-online.com are 5 Sphingosine-1-Phosphate Receptor 1 (S1PR1) Proteins from 2 different suppliers available. Additionally we are shipping S1PR1 Antibodies (195) and S1PR1 Kits (24) and many more products for this protein. A total of 238 S1PR1 products are currently listed.
Synonyms:
AI849002, CD363, CHEDG1, D1S3362, ECGF1, EDG-1, Edg1, fd11a07, Lpb1, S1p, S1p1, wu:fd11a07, zgc:92296
list all proteins Gene Name GeneID UniProt
S1PR1 1901 P21453
S1PR1 13609 O08530
Rat S1PR1 S1PR1 29733 P48303

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S1PR1 Proteins (S1PR1) by Origin

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Human Sphingosine-1-Phosphate Receptor 1 (S1PR1) interaction partners

  1. Model recombinant HDL (show HSD11B1 Proteins) (rHDL) particles formed in vitro with S1P (show MBTPS1 Proteins) incorporated into the particle initiated the internalization of S1PR1, whereas rHDL without supplemented S1P (show MBTPS1 Proteins) did not, suggesting that S1P (show MBTPS1 Proteins) transported in HDL (show HSD11B1 Proteins) can selectively activate S1PR1.

  2. Blocking of S1PR activity and inhibition of S1P (show MBTPS1 Proteins) synthesis led to decreased expression of fibrosis and tissue remodeling-related proteins in primary cultures of orbital fibroblasts derived from patients with GO.

  3. a lipid molecule repeatedly entered the receptor between the extracellular ends of TM1 (show TPM2 Proteins) and TM7, providing important insights into the pathway of ligand entry into the S1PR1 .

  4. Mature human thymocytes rely on S1P (show MBTPS1 Proteins)-R1 to migrate toward S1P (show MBTPS1 Proteins). Taken in the context of murine work demonstrating that S1P (show MBTPS1 Proteins) is required for thymocyte egress to the periphery.

  5. ApoM (show APOM Proteins)-bound sphingosine-1-phosphate regulates adhesion molecule (show NCAM1 Proteins) abundance, leukocyte-endothelial adhesion, and endothelial barrier function via sphingosine-1-phosphate receptor1.

  6. The S1P1,3 activation results in Akt (show AKT1 Proteins) phosphorylation and subsequent activation of eNOS (show NOS3 Proteins) via phosphorylation at serine(1177) and dephosphorylation at threonine(495).

  7. HDL (show HSD11B1 Proteins)-associated ApoM (show APOM Proteins) is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 and S1P3 (show S1PR3 Proteins) receptors on vascular endothelium.

  8. The present high prevalence of S1PR1 overexpression warrants the consideration of testicular diffuse large B-cell lymphoma as a distinct disease subtype and suggests the potential of the S1P/S1PR1 axis as a therapeutic target.

  9. S1PR1 inhibits the apoptosis of human myeloid leukemia (show BCL11A Proteins) cells and promotes their proliferation.

  10. These results suggest that S1P (show MBTPS1 Proteins) signaling plays a role in cell proliferation and drug resistance in multiple myeloma, and targeting this pathway will provide a new therapeutic direction for multiple myelomamanagement.

Mouse (Murine) Sphingosine-1-Phosphate Receptor 1 (S1PR1) interaction partners

  1. The study suggests that vascular leakage of albumin (show ALB Proteins)-sized particles in ApoM (show APOM Proteins) deficiency is S1P- and S1P1-dependent and this dependency exacerbates the response to inflammatory stimuli.

  2. The present results suggest that Fas (show FAS Proteins)/S1P1 signaling via activation of NF-kappaB (show NFKB1 Proteins) in osteoclast precursor cells is a key factor in the pathogenesis of rheumatoid arthritis in the temporomandibular joint.

  3. Activation of the S1P1 receptor in cardiac mast cells confers cardio-protection during cardiac mast cell degranulation.

  4. this study shows that S1P1 downregulation mirrors the strength and persistence of the TCR stimulation, limiting egress of high affinity T cells from lymph nodes

  5. After axonal damage, S1PR1 expression was decreased in retinal neurons

  6. These results indicate a role for S1P signaling in Bordetella pertussis-mediated pathology.

  7. These results suggest that S1P signaling via S1P1 in cardiomyocytes plays a previously unknown and necessary role in heart development in mice in expansion of cardiomyocyte number and ventricular compaction.

  8. Profound depletion of S1p renders both erythrocyte and platelet pools necessary for recovery during anaphylactic shock.

  9. S1P induced chemotaxis in M1 macrophages and changed cytokine production in M2 macrophages. Phagocytosis was not affected by S1P-signalling.

  10. Data indicate that forkhead box F1 (Foxf1 (show FOXF1 Proteins)) deletion from endothelial cells decreases the abundance of sphingosine 1-phosphate receptor 1 (S1PR1).

Cow (Bovine) Sphingosine-1-Phosphate Receptor 1 (S1PR1) interaction partners

  1. Polymorphisms in promoter regions of PDHB (show PDHB Proteins), SORBS1 (show SORBS1 Proteins), and EDG1 genes showing marbling-associated expression changes.

  2. we detected 2 novel SNPs, referred to as g.1475435G>A and g.1471620G>T, in the 5' flanking region of the EDG1 between low-marbled and high-marbled steer groups

  3. EDG1 SNPs, although they may not be regarded as a causal mutation, may be useful for effective marker-assisted selection to increase the levels of marbling in Japanese Black beef cattle.

S1PR1 Protein Profile

Protein Summary

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion.

Alternative names and synonyms associated with S1PR1

  • sphingosine-1-phosphate receptor 5a (s1pr5a)
  • sphingosine-1-phosphate receptor 1 (S1PR1)
  • sphingosine-1-phosphate receptor 1 (S1pr1)
  • AI849002 protein
  • CD363 protein
  • CHEDG1 protein
  • D1S3362 protein
  • ECGF1 protein
  • EDG-1 protein
  • Edg1 protein
  • fd11a07 protein
  • Lpb1 protein
  • S1p protein
  • S1p1 protein
  • wu:fd11a07 protein
  • zgc:92296 protein

Protein level used designations for S1PR1

sphingosine-1-phosphate receptor 1 , sphingosine 1-phosphate receptor 1 , endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 , S1P receptor 1 , S1P receptor Edg-1 , endothelial differentiation G-protein coupled receptor 1 , sphingosine 1-phosphate receptor EDG1 , sphingosine 1-phosphate receptor Edg-1 , endothelial differentiation sphingolipid G-protein-coupled receptor 1 , lysophospholipid receptor B1 , EDG1 (Edg1) , S1P1

GENE ID SPECIES
492350 Danio rerio
100174622 Pongo abelii
424462 Gallus gallus
457063 Pan troglodytes
490138 Canis lupus familiaris
716813 Macaca mulatta
100050049 Equus caballus
1901 Homo sapiens
13609 Mus musculus
29733 Rattus norvegicus
281135 Bos taurus
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