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Our study shows that palmitoylation of CaVbeta2a is necessary for CaValpha1 trafficking to the plasma membrane. However, excessive number of palmitoylated CaVbeta2a leads to Ca(2 (show CA2 Proteins)+) overload and beta cell death.
Study showed that CACNB2 is a possible candidate hypertrophy-modifying gene contributing to disease variability of MYBPC3 (show MYBPC3 Proteins)-associated familial hypertrophic cardiomyopathy
Five serious mental disorders and three major cardiovascular diseases have recently been linked to the CACNB2 gene coding for the Cavbeta2 subunits
ADM (show ADM Proteins) genotype AA was associated with the highest values of systolic and diastolic blood pressure (BP), while CACNB2 genotype CC carriers had the highest values of diastolic BP in childhood.
In the gene-based analysis, CACNB2 and CTCF (show CTCF Proteins) showed the strongest evidence for association with schizophrenia in both the present samples and in those of the Psychiatric Genetics Consortium datasets.
Chronic atrial fibrillation increases miR (show MLXIP Proteins)-21 expression in human atrial myocytes and decreases I(Ca,L) density by downregulating CACNA1C (show CACNA1C Proteins)/CACNB2 expression.
Three rare missense mutations of CACNB2 (G167S, S197F, and F240L) found in Autism Spectrum Disorders (ASD (show ARSD Proteins))-affected families, are reported.
High prevalence of CACNA2D1 (show CACNA2D1 Proteins), SCN5A (show SCN5A Proteins), and CACNB2 genetic variants in the Danish population previously associated with Brugada syndrome has been found in new exome data.
Association of the SNP rs2932538 in MOV10 and SNP rs4373814 in CACNB2 with an increased risk of hypertension in a Chinese Han population.
Genetic variations in CYP17A1, CACNB2 and PLEKHA7 were related to blood pressure traits and/or hypertension in Chinese She population.
Membrane Interaction of the beta2e Subunit of Voltage-Gated Ca(2 (show CA2 Proteins)+) Channels
Dynamic phospholipid interaction of beta2e subunit regulates the gating of voltage-gated Ca2 (show CA2 Proteins)+ channels.
a model in which CaVbeta promotes anterograde trafficking of the L-type channels by anchoring them to actin filaments in their itinerary to the plasma membrane.
We conclude that phosphorylation of the C-terminal sites in Ca(v)beta(2), Ser (show SIGLEC1 Proteins)(1928), Ser (show SIGLEC1 Proteins)(1512), and Ser (show SIGLEC1 Proteins)(1570) of the Ca(v)1.2 (show CACNA1C Proteins) protein is functionally not involved in the adrenergic regulation of the murine cardiac Ca(v)1.2 (show CACNA1C Proteins) channel.
phosphorylation event is one mechanism underlying ahnak1 (show AHNAK Proteins)'s modulator function on Cav1.2 (show CACNA1C Proteins) channel activity.
Mice with cardiac-specific sequestration of the beta-subunit (show POLG Proteins) of the L-type calcium channel
preferential binding between Cacna1c (show CACNA1C Proteins) and Cacnb2 in the heart
Ca(V)beta(2) has an essential role in regulating the abundance and properties of Ca(V)1.3 (show CACNA1D Proteins) channels in IHCs and, thereby, is critical for IHC development and synaptic encoding of sound.
expression of various CaVbeta2 proteins may be used to adapt the properties of LTCCs to changing myocardial requirements during development
This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described.
calcium channel, voltage-dependent, beta 2 subunit
, L-type calcium channel beta subunit
, voltage-dependent L-type calcium channel subunit beta-2
, voltage-dependent L-type calcium channel subunit beta-2-like
, calcium channel voltage-dependent subunit beta 2
, lambert-Eaton myasthenic syndrome antigen B
, myasthenic (Lambert-Eaton) syndrome antigen B
, cardiac calcium channel beta subunit
, cardiac calcium channel beta-subunit