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Browse our COL4a5 Proteins (COL4a5)

Full name:
Collagen, Type IV, alpha 5 Proteins (COL4a5)
On www.antibodies-online.com are 2 Collagen, Type IV, alpha 5 (COL4a5) Proteins from 2 different suppliers available. Additionally we are shipping COL4a5 Antibodies (44) and COL4a5 Kits (1) and many more products for this protein. A total of 50 COL4a5 products are currently listed.
Synonyms:
ASLN, ATS, CA54, col4a5, fj65e07, im:7157877, RGD1565499, si:ch211-174g17.1, wu:fj65e07
list all proteins Gene Name GeneID UniProt
COL4a5 1287 P29400
Mouse COL4a5 COL4a5 12830  
Rat COL4a5 COL4a5 363457  

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COL4a5 Proteins (COL4a5) by Origin

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Human Collagen, Type IV, alpha 5 (COL4a5) interaction partners

  1. Synonymous COL4A5 substitution responsible for X-linked Alport syndrome.

  2. Sanger sequencing of these regions identified a novel splicesite mutation in intron 9 (c.547-3C>A) of the COL4A5 gene. Subsequent cDNA analysis revealed that c.547- 3C>A led to skipping of exon 10, which resulted in an in-frame deletion of 21 amino acids from the a5 chain of type IV collagen (show COL4 Proteins). This is the first report of the novel c.547-3C>A splicing mutation in the collagen domain of COL4A5 gene.

  3. Coinheritance of COL4A5 and MYO1E (show MYO1E Proteins) mutations accentuate the severity of kidney disease.

  4. Case Report: subepidermal blistering disease with autoantibodies to multiple laminin subunits which developed autoantibodies to COL4A5 associated with membranous glomerulonephropathy.

  5. New COL4A5 mutations among Portuguese patients with collagen IV (show COL4 Proteins)-related nephropathies were identified in unrelated individuals.

  6. alpha5(IV), but not alpha1(IV), promotes lung cancer cell proliferation and tumor angiogenesis through non-integrin collagen receptor (show ITGA2 Proteins) DDR1 (show DDR1 Proteins)-mediated ERK (show EPHB2 Proteins) activation.

  7. we identified seven families with associated mutations in COL4A3 (show COL4a3 Proteins) and COL4A4 genes and four families with associated mutations in COL4A4 and COL4A5. We did not find kindreds with digenic inheritance attributable to mutations in COL4A3 (show COL4a3 Proteins) and COL4A5

  8. The expression of collagen type IV (show COL4 Proteins) and its alpha chains (alpha1-6) was investigated in different endothelial cell culture systems in vitro qualitatively and quantitatively.

  9. New deletion in COL4A6 (show COL4a6 Proteins)/COL4A5 related to diffuse esophageal leiomyomatosis associated with Alport syndrome in a Chinese family.

  10. We identified a nucleotide change 1226 G>A, causing amino acid substitutions of Gly to Asp (show ASIP Proteins) at position 409, in hemizygosis in the exon 20 of COL4A5 gene (proband 16 and the 13 in Alport syndrome pedigree

Mouse (Murine) Collagen, Type IV, alpha 5 (COL4a5) interaction partners

  1. Findings indicate a role for collagen alpha-5(IV) chain (Col4a5) in the regulation of macrophage responses to mycobacterial infection and identify Col4a5 as a potential target for the host-directed anti-mycobacterial therapy.

  2. alpha5(IV), but not alpha1(IV), promotes lung cancer cell proliferation and tumor angiogenesis through non-integrin collagen receptor (show ITGA2 Proteins) DDR1 (show DDR1 Proteins)-mediated ERK (show EPHB2 Proteins) activation.

  3. In murine embryos, collagen IV (show COL4 Proteins) subunits alpha1(IV), alpha2(IV), alpha5(IV) and alpha6(IV) were detected in the basement membrane surrounding the lens vesicle, and they persisted in the capsule until adulthood.

  4. In kidney, when expressed onto Col4a3 (show COL4a3 Proteins)(-/-) background, human alpha3(IV (show COL4a3 Proteins)) chain restored expression of and co-assembled with mouse alpha4 and alpha5(IV) chains at sites where human alpha3(IV (show COL4a3 Proteins)) was expressed. All three chains required for network assembly.

  5. Alpha3(IV (show COL4a3 Proteins)), alpha4(IV), and alpha5(IV) chains form a complex, which is a heterotrimer, and a defect in complex formation might be one of the molecular mechanisms underlying the pathogenesis of Alport syndrome.

  6. the proximal bifunctional promoter regulates the expression of the alpha5(IV) and alpha6(IV) genes in a cell-specific manner and demonstrates promoter plasticity in growth factor regulation of type IV collagen (show COL4 Proteins) genes in different tissues of the body.

COL4a5 Protein Profile

Protein Summary

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Alternatively spliced transcript variants have been identified for this gene.

Alternative names and synonyms associated with COL4a5

  • collagen, type IV, alpha 5 (COL4A5)
  • collagen, type IV, alpha 1 (col4a1)
  • collagen, type IV, alpha 5 (LOC100285389)
  • collagen, type IV, alpha 5 (Col4a5)
  • ASLN protein
  • ATS protein
  • CA54 protein
  • col4a5 protein
  • fj65e07 protein
  • im:7157877 protein
  • RGD1565499 protein
  • si:ch211-174g17.1 protein
  • wu:fj65e07 protein

Protein level used designations for COL4a5

collagen, type IV, alpha 5 , type IV collagen alpha 5-like , type IV collagen alpha 5 chain , collagen alpha-5(IV) chain-like , collagen IV, alpha-5 polypeptide , collagen alpha-5(IV) chain , collagen of basement membrane, alpha-5 chain , dA149D17.3 , dA24A23.1 , collagen type IV alpha5 chain , procollagen type IV alpha 5 , procollagen, type IV, alpha 5 , collagen, type IV, alpha 5 (Alport syndrome) , type IV collagen alpha 5

GENE ID SPECIES
511602 Bos taurus
554269 Danio rerio
703814 Macaca mulatta
100519180 Sus scrofa
465805 Pan troglodytes
100285389 Zea mays
1287 Homo sapiens
12830 Mus musculus
363457 Rattus norvegicus
403466 Canis lupus familiaris
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