Browse our Mitofusin 2 (MFN2) ELISA Kits

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Mitofusin 2 ELISA Kits (MFN2)
On www.antibodies-online.com are 7 Mitofusin 2 (MFN2) ELISA Kits from 5 different suppliers available. Additionally we are shipping Mitofusin 2 Antibodies (172) and Mitofusin 2 Proteins (10) and many more products for this protein. A total of 199 Mitofusin 2 products are currently listed.
Synonyms:
anon-WO0125274.3, CG3869, CMT2A, CMT2A2, CPRP1, D630023P19Rik, Dmel\\CG3869, dmfn, Fzo, HSG, marf, Marf-1, mfn, MFN2, mg:cb01g09, si:dkeyp-104h9.2, wu:fb79a11
list all ELISA KIts Gene Name GeneID UniProt
MFN2 9927 O95140
MFN2 170731 Q80U63
MFN2 64476  

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Mitofusin 2 (MFN2) ELISA Kits by Reactivity

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More ELISA Kits for Mitofusin 2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Mitofusin 2 (MFN2) interaction partners

  1. Clu (show CLU ELISA Kits) is upstream of and binds to VCP (show vcp ELISA Kits) in vivo and promotes VCP (show vcp ELISA Kits)-dependent Marf degradation in vitro Marf accumulates in whole muscle lysates of clu (show CLU ELISA Kits)-deficient flies and is destabilized upon Clu (show CLU ELISA Kits) overexpression. Thus, Clu (show CLU ELISA Kits) is essential for mitochondrial homeostasis and functions in concert with Parkin (show PARK2 ELISA Kits) and VCP (show vcp ELISA Kits) for Marf degradation to promote damaged mitochondrial clearance.

  2. lack of ChChd3 leads to inactivation of Hippo activity under normal development, which is also dependent on the transcriptional coactivator Yorkie (Yki (show YAP1 ELISA Kits)). Furthermore, loss of ChChd3 induces oxidative stress and activates the JNK (show MAPK8 ELISA Kits) pathway. In addition, depletion of other mitochondrial fusion components, Opa1 (show OPA1 ELISA Kits) or Marf, inactivates the Hippo pathway as well.

  3. Marf is required for mitochondrial fusion and transport in long axons.

  4. Expression of Mfn2 and endoplasmic reticulum (ER) stress reduction in flies lacking Marf corrected ER shape, attenuating the developmental and motor defects.

  5. Parkin (show PARK2 ELISA Kits) deficiency and resulting mitophagic disruption produces cardiomyopathy which can be contained by suppressing mitofusin.

  6. mfn2 mutations alter mitochondrial dynamics and induce retinal and cardiac pathology

  7. Data report here that Drosophila Reaper can induce mitochondrial fragmentation by binding to and inhibiting the pro-fusion protein MFN2 and its Drosophila counterpart dMFN/Marf.

  8. MARF and Opa1 (show OPA1 ELISA Kits) control mitochondrial and cardiac function in Drosophila.

  9. The PINK1/Parkin (show PARK2 ELISA Kits) pathway affects mitochondrial fission/fusion as suggested by previous genetic interaction studies.

  10. Dmfn-mRNA was widely expressed during embryogenesis accumulating in the mesoderm and endoderm during gut (show GUSB ELISA Kits) development, during oogenesis with transcripts maternally deposited into the early embryo and in the male germ line.

Human Mitofusin 2 (MFN2) interaction partners

  1. Smad2 (show SMAD2 ELISA Kits) is a key scaffold, allowing RIN1 (show RIN1 ELISA Kits) to act as a GTP (show AK3 ELISA Kits) exchange factor for MFN2-GTPase (show RACGAP1 ELISA Kits) activation to promote mitochondrial ATP synthesis and suppress superoxide production during mitochondrial fusion.

  2. our results suggest that KAP1 (show CDKN3 ELISA Kits) Ser473 phosphorylation acts through MFN2 reduction to restrict mitochondrial hyperfusion, thereby contributing to cancer cell survival under conditions of sustained metabolic stress

  3. Mfn2 downregulation or the exogenous expression of normal Parkin (show PARK2 ELISA Kits) restored cytosolic Ca(2 (show CA2 ELISA Kits)+) transients in fibroblasts from patients with PARK2 (show PARK2 ELISA Kits) mutations, a catalytically inactive Parkinson's disease (PD)-related Parkin (show PARK2 ELISA Kits) variant had no effect. Parkin (show PARK2 ELISA Kits) is directly involved in regulating ER-mitochondria contacts and provide new insight into the role of the loss of Parkin (show PARK2 ELISA Kits) function in PD development

  4. siRNA knockdown of mitofusin-2 (Mfn2), a protein that is involved in the tethering of endoplasmic reticulum and mitochondria, leads to increased contact between the two organelles.

  5. Taken together, these data suggest that the striking reduction in mitochondria in MNs (show FLNA ELISA Kits) expressing mutant MFN2 is not the result of impaired biogenesis, but more likely the consequence of enhanced mitophagy.

  6. our findings indicate miR (show MLXIP ELISA Kits)-106a as an important factor to promote hypertrophic progress and suggest miR (show MLXIP ELISA Kits)-106a as a new molecular target for the treatment of pathological hypertrophy. The present study also uncovered a novel relationship between miR (show MLXIP ELISA Kits)-106a and Mfn2, with Mfn2 as a downstream signaling mediator of miR (show MLXIP ELISA Kits)-106a.

  7. The results of the present study demonstrated that Resveratrol may protect bronchial epithelial cells from cigarette smoke -induced apoptosis in vitro by preventing mitochondrial dysfunction, and MFN2 may be associated with the anti-apoptotic functions of RSV in HBE (show HBe1 ELISA Kits) cells.

  8. Low MFN2 expression in hepatocellular carcinoma indicated a worse overall survival.

  9. Low expression of MFN2 is associated with lung adenocarcinoma.

  10. Between 1999 and 2012, the genetic diagnosis of MFN2 mutation was made in 11 children who were treated in our department for different neurological symptoms. We found 5 different mutations in the MFN2 gene in 6 unrelated families

Mouse (Murine) Mitofusin 2 (MFN2) interaction partners

  1. Study demonstrated that deregulation of mfn2 played a critical role in the mitochondrial disorder during the progression of Alzheimer's disease, and its decreased expression was regulated at least in part by miR (show MLXIP ELISA Kits)-195. Therefore, upregulation of mfn2 expression by decreasing the level of miR (show MLXIP ELISA Kits)-195 might be a potential new therapeutic strategy for treatment of Alzheimer's disease.

  2. Mfn2 downregulation or the exogenous expression of normal Parkin (show PARK2 ELISA Kits) restored cytosolic Ca(2 (show CA2 ELISA Kits)+) transients in fibroblasts from patients with PARK2 (show PARK2 ELISA Kits) mutations, a catalytically inactive Parkinson's disease (PD)-related Parkin (show PARK2 ELISA Kits) variant had no effect. Parkin (show PARK2 ELISA Kits) is directly involved in regulating ER-mitochondria contacts and provide new insight into the role of the loss of Parkin (show PARK2 ELISA Kits) function in PD development.

  3. Altogether, these results demonstrate that Mfn2 is a mediator of mitochondria to lipid droplet interactions, influencing lipolytic processes and whole-body energy homeostasis.

  4. we demonstrated that by modulating mitochondrial energy metabolism through Mfn2 and mitochondrial Ca2 (show CA2 ELISA Kits)+, PPAR-b (show PPARD ELISA Kits) took an important role in neuronal differentiation induced by flavonoid compound 4a

  5. Furthermore, analysis of muscle Mfn2-deficient mice revealed that aging-induced Mfn2 decrease underlies the age-related alterations in metabolic homeostasis and sarcopenia.

  6. Mice hemizygous for a pathogenic Mfn2 allele exhibit hind limb/foot gait deficits and phenotypic perturbations in nerve and muscle.

  7. We found that mouse embryonic fibroblasts lacking Mfn2 have altered lipid droplet morphology. However, triacylglycerol biosynthesis was not dependent on ER-mitochondrial tethering mediated by mitofusins. Lastly, Mfn2 does not have a role in adipocyte differentiation.

  8. knockdown of Mfn2 in adipo and osteogenesis and the overexpression of a dominant negative form of Drp1 (show CRMP1 ELISA Kits) during chondrogenesis resulted in a loss of differentiation ability

  9. SIRT1 (show SIRT1 ELISA Kits) overexpression substantially increased autophagy in wild-type cells, but not in MFN2-deficient cells.

  10. mitofusin 2 overexpression may attenuate hypoxia-induced apoptosis.

Zebrafish Mitofusin 2 (MFN2) interaction partners

  1. These results highlight the essential role of mitofusin 2 in the motor axon development and demonstrate the potential of zebrafish as a suitable and complementary platform for dissecting pathogenetic mechanisms of MFN2 mutations in vivo.

Cow (Bovine) Mitofusin 2 (MFN2) interaction partners

  1. A highly unusual splicing defect, where an exonic single base exchange leads to the retention of the preceding intron, was identified in MFN2 (show MFN1 ELISA Kits).

Mitofusin 2 (MFN2) Antigen Profile

Antigen Summary

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

Alternative names and synonyms associated with Mitofusin 2 (MFN2)

  • mitofusin 2 (MFN2) Elisa Kit
  • Mitochondrial assembly regulatory factor (Marf) Elisa Kit
  • mitofusin 2 (mfn2) Elisa Kit
  • mitofusin 2 (Mfn2) Elisa Kit
  • mitofusin 2 (LOC100350119) Elisa Kit
  • anon-WO0125274.3 Elisa Kit
  • CG3869 Elisa Kit
  • CMT2A Elisa Kit
  • CMT2A2 Elisa Kit
  • CPRP1 Elisa Kit
  • D630023P19Rik Elisa Kit
  • Dmel\\CG3869 Elisa Kit
  • dmfn Elisa Kit
  • Fzo Elisa Kit
  • HSG Elisa Kit
  • marf Elisa Kit
  • Marf-1 Elisa Kit
  • mfn Elisa Kit
  • MFN2 Elisa Kit
  • mg:cb01g09 Elisa Kit
  • si:dkeyp-104h9.2 Elisa Kit
  • wu:fb79a11 Elisa Kit

Protein level used designations for Mitofusin 2 (MFN2) ELISA Kits

CG3869-PA , CG3869-PB , CG3869-PC , Marf-PA , Marf-PB , Marf-PC , drosophila mitofusin , mitochondrial assembly regulatory factor , mitofusin , mitofusin 2 , mitofusin-2 , mitofusin-2-like , hyperplasia suppressor , transmembrane GTPase MFN2 , HSG protein , hypertension related protein 1 , hypertension-related protein 1 , hypertension-related protein , mitochondrial transmembrane GTPase FZO1A

GENE ID SPECIES
100055966 Equus caballus
31581 Drosophila melanogaster
457958 Pan troglodytes
549268 Xenopus (Silurana) tropicalis
100172672 Pongo abelii
100186475 Ciona intestinalis
100427191 Macaca mulatta
100470367 Ailuropoda melanoleuca
100599174 Nomascus leucogenys
9927 Homo sapiens
170731 Mus musculus
64476 Rattus norvegicus
567448 Danio rerio
431918 Xenopus laevis
419484 Gallus gallus
487439 Canis lupus familiaris
534574 Bos taurus
100350119 Oryctolagus cuniculus
100512172 Sus scrofa
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