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Gene expression level of NRD1 is significantly higher in AD patients when compared to normal controls.
MRNA expression of NRD1 was upregulated in 56% of ESCC tissue samples.
This study demonistrated that alcohol-dependent reduction of nardilysin in cell culture and nervous tissue points to an implication of the enzyme in the pathophysiology of alcoholism.
possible roles of nardilysin in Alzheimer disease, Down syndrome, schizophrenia, mood disorders, alcohol abuse, heroin addiction and cancer; show that nardilysin is a Janus-faced enzyme with regard to brain pathology-- probably neuropathogenic in some diseases, but neuroprotective in others [review]
SH-SY5Y cells, stably transfected with green fluorescent protein-tagged-p42 (show EPB42 ELISA Kits)(IP4) show enhanced NRD (show PRDM1 ELISA Kits) protein expression already at an earlier time point after retinoic acid stimulation.
NRD1 interacts with p53 (show TP53 ELISA Kits) mutant R273H
These results demonstrate that gastric cancer cell growth is maintained by autonomous TNF-alpha (show TNF ELISA Kits)-NF-kappaB (show NFKB1 ELISA Kits) and IL-6 (show IL6 ELISA Kits)-STAT3 (show STAT3 ELISA Kits) signalling, and that NRDc and ADAM proteases turn on these signalling cascades by stimulating ectodomain shedding of TNF-alpha (show TNF ELISA Kits).
Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation.
Several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample for KIAA0040, NRD1 and THSD7B, respectively.
Tubulin (show TUBB ELISA Kits) potentiates the interaction of the metalloendopeptidase (show THOP1 ELISA Kits) nardilysin with the neuronal scaffold protein (show HOMER1 ELISA Kits) p42IP4 (show ADAP1 ELISA Kits)/centaurin-alpha1 (ADAP1 (show ADAP1 ELISA Kits)).
Nardilysin Is Required for Maintaining Pancreatic beta-Cell Function
deletion of nardilysin prevents the development of diet-induced steatohepatitis and liver fibrogenesis
The use of proteolysis to study the structure of nardilysin.
Studies extend the range of potential substrates for nardilysin and further substantiate that nardilysin is a true peptidase.
miniglucagon-generating endopeptidase is composed of NRDc and aminopeptidase B (show RNPEP ELISA Kits) acting sequentially
role for nardilysin in oocyte meiosis through its dynamic translocation from cytosol to nucleus, and then to the spindle apparatus
NRDc regulates axonal maturation and myelination in the nervous system, in part, through the modulation of NRG1 (show NRG1 ELISA Kits) shedding
The acidic stretch of nardilysin, expressed as a fusion protein with glutathione S-transferase (show GSTa2 ELISA Kits) and compared to the native enzyme with respect to spermine binding, functions as an autonomous domain.
This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene.
, N-arginine dibasic convertase 1
, nardilysin 1 (N-arginine dibasic convertase)
, nardilysin, N-arginine dibasic convertase 1
, nardilysin, N-arginine dibasic convertase, NRD convertase 1
, N-arginine dibasic convertase
, nardilysin (N-arginine dibasic convertase)
, Nardilysin-like protein