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anti-Human LRP1 Antibodies:
anti-Mouse (Murine) LRP1 Antibodies:
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Human Polyclonal LRP1 Primary Antibody for IHC, WB - ABIN2787740
Hentschke, Poli-de-Figueiredo, da Costa, Kurlak, Williams, Mistry: Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype. in Journal of lipid research 2013
Show all 3 Pubmed References
Human Monoclonal LRP1 Primary Antibody for FACS - ABIN2472830
Moestrup, Gliemann, Pallesen: Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. in Cell and tissue research 1992
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Human Monoclonal LRP1 Primary Antibody for ELISA, FACS - ABIN2472827
Moestrup, Hokland: Surface expression of the alpha 2-macroglobulin receptor on human malignant blood cells. in Leukemia research 1992
Show all 4 Pubmed References
Poor LRP1 expression in T cells depends on shedding. Integrin ligands and CXCL12 (show CXCL12 Antibodies) antagonize shedding through a TSP-1 (show THBS1 Antibodies)-dependent pathway and ligation of CD28 (show CD28 Antibodies) antagonizes shedding independent of TSP-1 (show THBS1 Antibodies).
Altered Met receptor phosphorylation and LRP1-mediated uptake in cells lacking carbohydrate-dependent lysosomal targeting
LRP1 single-nucleotide polymorphism is associated with migraine.
Electrostatic potential calculations suggested a competition between negatively charged GAGs and highly negatively charged complement-like domains of LRP-1 for the binding to a positively charged area of TIMP-3 (show TIMP3 Antibodies) as an underlying mechanism.
findings revealed a pH-dependent release of the ligand associated with a conformational change of the receptor. In summary, this investigation of the complete LRP1 ectodomain significantly advances our understanding of this important receptor and provides the basis for further elucidating the mechanism of action of LRP1 in a whole and integrated system.
although fVIII (show F8 Antibodies) bound avidly to soluble forms of clusters II and IV from LRP1, only soluble cluster IV competed with the binding of fVIII (show F8 Antibodies) to full-length LRP1, revealing that cluster IV represents the major fVIII (show F8 Antibodies) binding site in LRP1.
LRP1 protein expression in human abdominal aortic aneurysm tissues may be down-regulated by miR (show MLXIP Antibodies)-205 through translational inhibition, resulting in a reduced clearance of pericellular MMP-9 (show MMP9 Antibodies), promoting aneurysm formation.
data also reveal that D1D2 is able to bind to a second distinct site on LRP1 to form a monovalent complex. The studies confirm the canonical model for ligand recognition by this class of receptors, which is initiated by pairs of lysine residues that dock into acidic pockets on the receptor
results indicate that genetic variations in LRP1 and ULK4 contribute to risk for presenting with an acute aortic dissection
Considering that LRP-1, by mediating the clearance of matrix metalloproteinases, is involved in the regulation of extracellular matrix remodeling and cell migration, we conclude that a decreased expression of LRP-1 could be involved with the increasing activity of MMPs shown in cancers.
Therefore, we concluded that the beneficial effects of LF might be due to an increase of autophagy activity via AMPK (show PRKAA1 Antibodies) signaling through the LRP1 receptor. These findings provide a novel insight into the physiological role of LF for the maintenance of cellular and tissue homeostasis.
This study demonstrated that LRP1 suppresses microglial activation by modulating JNK (show MAPK8 Antibodies) and NF-kappaB (show NFKB1 Antibodies) signaling pathways. Down-regulation of LRP1 levels and the increased pro-inflammatory signaling may result in a vicious cycle, in which the two events synergistically promote microglial activation
ApoC-III (show APOC3 Antibodies) inhibits turnover of TG-rich lipoproteins primarily through a hepatic clearance mechanism mediated by the LDLR (show LDLR Antibodies)/LRP1 axis
These results provide evidence supporting a key role for the p38 MAPK (show MAPK14 Antibodies) signaling pathway which is involved in the regulation of Abeta1-42 internalization in the parietal cortex and hippocampus of mouse through LRP1 in vivo.
BMPER (show BMPER Antibodies)/low-density lipoprotein receptor-related protein 1 axis plays a pivotal role in pulmonary inflammatory response.
report that LRP1 expression is rapidly lost as oligodendrocyte progenitor cells differentiate, and is absent from all oligodendrocytes, including newborn oligodendrocytes
Results show evidence of low-density lipoprotein receptor-related protein 1 ( (LRP1) expression and activity modulation by Intravenous immunoglobulin (IVIg), and support the role of LRP1 as a partner of IVIg in the execution of its neuroprotective effects.
LRP1 deficiency in mature adipocytes promotes diet-induced inflammation and atherosclerosis.
TNF-alpha (show TNF Antibodies) blockade exerts antiatherosclerotic effects that are dependent on the presence of macrophage LRP1.
these results documented that LRP1 deficiency in hepatocytes promotes lipid accumulation and lipotoxicity through lysosomal-mitochondrial permeabilization and ER stress that ultimately result in cell death. Hence, LRP1 dysfunction may be a major risk factor in fatty liver disease progression.
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
low density lipoprotein receptor-related protein 1
, prolow-density lipoprotein receptor-related protein 1-like
, TbetaR-V/LRP-1/IGFBP-3 receptor
, alpha-2-macroglobulin receptor
, apolipoprotein E receptor
, prolow-density lipoprotein receptor-related protein 1
, type V tgf-beta receptor
, alpha 2-macroglobulin receptor
, lipoprotein receptor-related protein
, low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
, low-density lipoprotein receptor-related protein/alpha-2 macroglobulin receptor
, low-density lipoprotein receptor-related protein 1