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These data suggest that, without infection, inactivated-H5N1 induces mRNA expression of IL-6 (show IL6 ELISA Kits) and CXCL8 (show IL8 ELISA Kits) by a mechanism, or mechanisms, requiring interaction between viral hemagglutinin (show HA ELISA Kits) and alpha-2,3 sialic acid receptors at the cell membrane of host cells, and involves activation of P2Y6 purinergic receptors.
Rescuing miR (show MLXIP ELISA Kits)-185 expression to inhibit P2Y6 may represent a therapeutic strategy against human aortic vascular smooth muscle cells dysfunction and hypertension.
data demonstrate that HNP-1 (show DEFA1 ELISA Kits) induces IL-8 (show IL8 ELISA Kits) production not only through P2Y6, but also through additional P2 receptors via an ERK1/2 (show MAPK1/3 ELISA Kits)-dependent mechanism in intestinal epithelial cells.
nucleotides released during the airway inflammatory processes will activate P2Y6 receptors, which will lead to further release of inflammatory cytokines.
high millimolar concentrations of ATP increased IL-8 (show IL8 ELISA Kits) and MCP-1 (show CCL2 ELISA Kits) release by the glioma cells stimulated with suboptimal LPS (show IRF6 ELISA Kits) concentration which were blocked by P2X7 (show P2RX7 ELISA Kits) and P2Y6 antagonists
Data indicate that after P2Y6 receptor stimulation both phospholipase D (PLD (show PLD ELISA Kits)) and DGKzeta (show DGKZ ELISA Kits) enzymes are responsible for producing phosphatidic acid (PA).
Using rat P2Y6 recombinant protein expressed in human astrocytoma cells, the authors found that the P2Y6 receptor is highly selective for UDP over UTP.
Results indicate involvement of P2Y purinoceptors P2Y(1) and P2Y(6) receptors in ADP- and UDP-stimulated proliferation.
no obvious correlation was found between the expression of P2Y6 and breast cancer cell proliferation
Report role of ecto (show TRIM33 ELISA Kits)-NTPDases on UDP-sensitive P2Y (show P2RY1 ELISA Kits)(6) receptor activation during osteogenic differentiation of primary bone marrow stromal cells from postmenopausal women.
these findings suggest that the P2Y6 receptor plays a critical role in mediating microglial phagocytosis in radiation-induced brain injury.
P2Y6 UDP receptor, the most expressed P2Y (show P2RY1 ELISA Kits) receptor in mouse resistance arteries, is required for maintaining proper arterial tone.
The present study identifies mouse P2Y6 receptor as a regulator of cardiac development and cardiomyocyte function. P2Y6 receptor could constitute a therapeutic target to regulate cardiac hypertrophy.
These results suggest that increased formation of AT1R (show AGTRAP ELISA Kits)-P2Y6R heterodimers with age may increase the likelihood of hypertension induced by Ang II (show AGT ELISA Kits).
Study demonstrates that AgRP (show AGRP ELISA Kits) neurons express the purinergic receptor (show P2RX7 ELISA Kits) 6 (P2Y6), which is activated by uridine-diphosphate (UDP). In vivo, UDP induces ERK (show EPHB2 ELISA Kits) phosphorylation and cFos expression in AgRP (show AGRP ELISA Kits) neurons and promotes action potential firing of these neurons in brain slice recordings.
P2Y (show P2RY1 ELISA Kits)(6) receptor augments pro-inflammatory responses in macrophages
The results demonstrate the important role of P2Y6 as a danger signal in antiviral immune responses.
these data outline a novel role for the P2Y6 receptor in the induction of CXCL8/IL-8 (show IL8 ELISA Kits) production and barrier dysfunction in response to C. difficile toxin exposure and may provide a new therapeutic target for the treatment of CDI.
P2Y6 deficiency limits atherosclerosis and plaque inflammation in mice.
P2Y (show P2RY1 ELISA Kits)(6) receptor signaling pathway may be a potential therapeutic target for MSU (show BCKDHA ELISA Kits)-associated inflammatory diseases, such as tophaceous gout.
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
G-coupled nucleotide receptor
, P2 purinoceptor
, P2Y purinoceptor 6
, P2Y6 receptor
, P2Y ATP receptor 6
, G protein-coupled P2 receptor
, P2Y purinoceptor 3
, nucleoside diphosphate receptor
, P2Y6 nucleotide receptor
, pyrimidinergic receptor P2Y6