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These data suggest that, without infection, inactivated-H5N1 induces mRNA expression of IL-6 (show IL6 Proteins) and CXCL8 (show IL8 Proteins) by a mechanism, or mechanisms, requiring interaction between viral hemagglutinin (show HA Proteins) and alpha-2,3 sialic acid receptors at the cell membrane of host cells, and involves activation of P2Y6 purinergic receptors.
Rescuing miR (show MLXIP Proteins)-185 expression to inhibit P2Y6 may represent a therapeutic strategy against human aortic vascular smooth muscle cells dysfunction and hypertension.
data demonstrate that HNP-1 induces IL-8 production not only through P2Y6, but also through additional P2 receptors via an ERK1/2-dependent mechanism in intestinal epithelial cells.
nucleotides released during the airway inflammatory processes will activate P2Y6 receptors, which will lead to further release of inflammatory cytokines.
high millimolar concentrations of ATP increased IL-8 (show IL8 Proteins) and MCP-1 (show CCL2 Proteins) release by the glioma cells stimulated with suboptimal LPS (show IRF6 Proteins) concentration which were blocked by P2X7 (show P2RX7 Proteins) and P2Y6 antagonists
Data indicate that after P2Y6 receptor stimulation both phospholipase D (PLD) and DGKzeta enzymes are responsible for producing phosphatidic acid (PA).
Using rat P2Y6 recombinant protein expressed in human astrocytoma cells, the authors found that the P2Y6 receptor is highly selective for UDP over UTP.
Results indicate involvement of P2Y purinoceptors P2Y(1) and P2Y(6) receptors in ADP- and UDP-stimulated proliferation.
no obvious correlation was found between the expression of P2Y6 and breast cancer cell proliferation
Report role of ecto (show TRIM33 Proteins)-NTPDases on UDP-sensitive P2Y (show P2RY1 Proteins)(6) receptor activation during osteogenic differentiation of primary bone marrow stromal cells from postmenopausal women.
P2Y6 UDP receptor, the most expressed P2Y (show P2RY1 Proteins) receptor in mouse resistance arteries, is required for maintaining proper arterial tone.
The present study identifies mouse P2Y6 receptor as a regulator of cardiac development and cardiomyocyte function. P2Y6 receptor could constitute a therapeutic target to regulate cardiac hypertrophy.
These results suggest that increased formation of AT1R (show AGTRAP Proteins)-P2Y6R heterodimers with age may increase the likelihood of hypertension induced by Ang II (show AGT Proteins).
Study demonstrates that AgRP (show AGRP Proteins) neurons express the purinergic receptor (show P2RX7 Proteins) 6 (P2Y6), which is activated by uridine-diphosphate (UDP). In vivo, UDP induces ERK (show EPHB2 Proteins) phosphorylation and cFos expression in AgRP (show AGRP Proteins) neurons and promotes action potential firing of these neurons in brain slice recordings.
P2Y (show P2RY1 Proteins)(6) receptor augments pro-inflammatory responses in macrophages
The results demonstrate the important role of P2Y6 as a danger signal in antiviral immune responses.
these data outline a novel role for the P2Y6 receptor in the induction of CXCL8/IL-8 (show IL8 Proteins) production and barrier dysfunction in response to C. difficile toxin exposure and may provide a new therapeutic target for the treatment of CDI.
P2Y6 deficiency limits atherosclerosis and plaque inflammation in mice.
P2Y (show P2RY1 Proteins)(6) receptor signaling pathway may be a potential therapeutic target for MSU (show BCKDHA Proteins)-associated inflammatory diseases, such as tophaceous gout.
P2Y (show P2RY1 Proteins)(6) receptor may play an important role in the regulation of bone cell function in vivo.
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
G-coupled nucleotide receptor
, P2 purinoceptor
, P2Y purinoceptor 6
, P2Y6 receptor
, P2Y ATP receptor 6
, G protein-coupled P2 receptor
, P2Y purinoceptor 3
, nucleoside diphosphate receptor
, P2Y6 nucleotide receptor
, pyrimidinergic receptor P2Y6