Browse our P2RY6 Proteins (P2RY6)

Full name:
Pyrimidinergic Receptor P2Y, G-Protein Coupled, 6 Proteins (P2RY6)
On are 5 Pyrimidinergic Receptor P2Y, G-Protein Coupled, 6 (P2RY6) Proteins from 2 different suppliers available. Additionally we are shipping P2RY6 Antibodies (44) and many more products for this protein. A total of 53 P2RY6 products are currently listed.
2010204J23Rik, P2RY3, P2Y3, P2y6, P2Y6R
list all proteins Gene Name GeneID UniProt
P2RY6 5031 Q15077
P2RY6 233571 Q9ERK9
Rat P2RY6 P2RY6 117264 Q63371

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Human Pyrimidinergic Receptor P2Y, G-Protein Coupled, 6 (P2RY6) interaction partners

  1. data demonstrate that HNP-1 induces IL-8 production not only through P2Y6, but also through additional P2 receptors via an ERK1/2-dependent mechanism in intestinal epithelial cells.

  2. nucleotides released during the airway inflammatory processes will activate P2Y6 receptors, which will lead to further release of inflammatory cytokines.

  3. high millimolar concentrations of ATP increased IL-8 (show IL8 Proteins) and MCP-1 (show CCL2 Proteins) release by the glioma cells stimulated with suboptimal LPS (show IRF6 Proteins) concentration which were blocked by P2X7 (show P2RX7 Proteins) and P2Y6 antagonists

  4. Data indicate that after P2Y6 receptor stimulation both phospholipase D (PLD) and DGKzeta enzymes are responsible for producing phosphatidic acid (PA).

  5. Using rat P2Y6 recombinant protein expressed in human astrocytoma cells, the authors found that the P2Y6 receptor is highly selective for UDP over UTP.

  6. Results indicate involvement of P2Y purinoceptors P2Y(1) and P2Y(6) receptors in ADP- and UDP-stimulated proliferation.

  7. no obvious correlation was found between the expression of P2Y6 and breast cancer cell proliferation

  8. Report role of ecto (show TRIM33 Proteins)-NTPDases on UDP-sensitive P2Y (show P2RY1 Proteins)(6) receptor activation during osteogenic differentiation of primary bone marrow stromal cells from postmenopausal women.

  9. P2Y (show P2RY1 Proteins)(6) receptor signaling pathway may be a potential therapeutic target for MSU (show BCKDHA Proteins)-associated inflammatory diseases, such as tophaceous gout.

  10. P2Y6 receptor transgene is an important endogenous inhibitor of T cell function in mice with allergic pulmonary inflammation

Mouse (Murine) Pyrimidinergic Receptor P2Y, G-Protein Coupled, 6 (P2RY6) interaction partners

  1. P2Y6 UDP receptor, the most expressed P2Y (show P2RY1 Proteins) receptor in mouse resistance arteries, is required for maintaining proper arterial tone.

  2. The present study identifies mouse P2Y6 receptor as a regulator of cardiac development and cardiomyocyte function. P2Y6 receptor could constitute a therapeutic target to regulate cardiac hypertrophy.

  3. These results suggest that increased formation of AT1R (show AGTRAP Proteins)-P2Y6R heterodimers with age may increase the likelihood of hypertension induced by Ang II (show AGT Proteins).

  4. Study demonstrates that AgRP (show AGRP Proteins) neurons express the purinergic receptor (show P2RX7 Proteins) 6 (P2Y6), which is activated by uridine-diphosphate (UDP). In vivo, UDP induces ERK (show EPHB2 Proteins) phosphorylation and cFos expression in AgRP (show AGRP Proteins) neurons and promotes action potential firing of these neurons in brain slice recordings.

  5. P2Y (show P2RY1 Proteins)(6) receptor augments pro-inflammatory responses in macrophages

  6. The results demonstrate the important role of P2Y6 as a danger signal in antiviral immune responses.

  7. these data outline a novel role for the P2Y6 receptor in the induction of CXCL8/IL-8 (show IL8 Proteins) production and barrier dysfunction in response to C. difficile toxin exposure and may provide a new therapeutic target for the treatment of CDI.

  8. P2Y6 deficiency limits atherosclerosis and plaque inflammation in mice.

  9. P2Y (show P2RY1 Proteins)(6) receptor signaling pathway may be a potential therapeutic target for MSU (show BCKDHA Proteins)-associated inflammatory diseases, such as tophaceous gout.

  10. P2Y (show P2RY1 Proteins)(6) receptor may play an important role in the regulation of bone cell function in vivo.

P2RY6 Protein Profile

Protein Summary

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Alternative names and synonyms associated with P2RY6

  • pyrimidinergic receptor P2Y, G-protein coupled, 6 (P2RY6)
  • pyrimidinergic receptor P2Y, G-protein coupled, 6 (P2ry6)
  • 2010204J23Rik protein
  • P2RY3 protein
  • P2Y3 protein
  • P2y6 protein
  • P2Y6R protein

Protein level used designations for P2RY6

G-coupled nucleotide receptor , P2 purinoceptor , P2Y purinoceptor 6 , P2Y6 receptor , P2Y ATP receptor 6 , G protein-coupled P2 receptor , P2Y purinoceptor 3 , nucleoside diphosphate receptor , P2Y6 nucleotide receptor , pyrimidinergic receptor P2Y6

5031 Homo sapiens
233571 Mus musculus
117264 Rattus norvegicus
396114 Gallus gallus
485202 Canis lupus familiaris
100512849 Sus scrofa
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