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Protein expression of alpha-Parvin increases with colorectal cancer progression.
PARVA promotes metastasis by modulating ILK (show ILK ELISA Kits) signalling pathway in lung adenocarcinoma
alpha-Parvin, a pseudopodial constituent, was found to promote migration of breast cancer cells and to be expressed exclusively by Invasive lobular carcinoma
Actopaxin plays a role in hepatocellular carcinoma progression and metastasis, by way of regulation of cell invasiveness and motility, an epithelial-mesenchymal transition process, and chemosensitivity to cytotoxic drugs.
beta2-adaptin (show AP2B1 ELISA Kits) is shown to bind to the focal adhesion protein actopaxin and localize to focal adhesions during cells spreading in an actopaxin dependent manner
alpha-parvin, beta-parvin (show PARVB ELISA Kits) and migfilin (show FBLIM1 ELISA Kits) were expressed in tumor cells in 53%, 2%, 28% and 53% of effusions and 57%, 20%, 83% and 25% of solid lesions, respectively.
Actopaxin phosphorylation is required for matrix degradation and cell invasion via regulation of Rho GTPase (show RACGAP1 ELISA Kits) signaling.
results also identify the integrin-linked kinase (ILK (show ILK ELISA Kits)) and alpha-parvin proteins as a new molecular partner and target, respectively, of the Lnk (show SH2B3 ELISA Kits) adaptor.
the alpha-parvin CH2 (show Acyp1 ELISA Kits)-paxillin (show PXN ELISA Kits) LD1 complex has a role in focal adhesion assembly
inhibition of the ILK (show ILK ELISA Kits)-alpha-parvin complex is sufficient, although not necessary, for promotion of apoptosis
this study has identified a new role for Parvin and alphaPix (show ARHGEF6 ELISA Kits) downstream of the integrin-ILK (show ILK ELISA Kits) signaling axis for mammary epithelial cell differentiation.
These results provide important evidence for a crucial role of the PINCH-1 (show LIMS1 ELISA Kits)-ILK (show ILK ELISA Kits)-alpha-parvin complex in the control of podocyte adhesion, morphology, and survival.
Results describe the roles of the ILK (show ILK ELISA Kits)-PINCH (show LIMS1 ELISA Kits)-parvin triad proteins in the maturation of focal adhesions.
Findings show that alpha-pv represents an essential adhesion checkpoint that controls RhoA (show RHOA ELISA Kits)/ROCK-mediated contractility in vSMCs.
This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival.
, calponin-like integrin-linked kinase-binding protein
, matrix-remodeling-associated protein 2