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role of TRIB1 in cell cycle and survival that is mediated via the modulation of NFkappaB signaling.
the co-operativity observed between MYC (show MYC ELISA Kits) and TRIB1 in the absence of PML (show PML ELISA Kits)/RARA (show RARA ELISA Kits) show that, outside of acute promyelocytic leukemia (show PML ELISA Kits), gain of both genes may drive selection for trisomy 8.
The crucial role of TRIB1 in cisplatin-induced enrichment of CSC and drug resistance was verified by knockdown TRIB1. Interestingly, cisplatin treatment also contributed to the increasement of HDAC (show HDAC3 ELISA Kits), the interaction of TRIB1 with HDAC (show HDAC3 ELISA Kits), and inactivation of p53 (show TP53 ELISA Kits).
Trib1 formed a complex with pHDAC1.
Studies indicate that tribbles homolog 1 (Drosophila) protein appear to be involved in some of the most common diseases, such as cancer, metabolic disease and hyperlipidaemia.
Studies suggest that pseudo-kinase family of tribbles (TRIB) proteins TRIB1, TRIB2 (show TRIB2 ELISA Kits) and TRIB3 (show TRIB3 ELISA Kits) play roles in pathogenesis of rheumatoid arthritis (RA) and osteoarthritis.
Studies indicate that the minor allele of a single nucleotide polymorphism (SNP, rs6982502) in the regulatory sequence reduces the activity of the tribbles homolog 1 (Drosophila) protein (TRIB1) promoter.
Studies suggest that pseudo-kinase family of tribbles (TRIB) proteins TRIB1, TRIB2 (show TRIB2 ELISA Kits) and TRIB3 (show TRIB3 ELISA Kits) were involved in the pathogenesis of inflammation.
Studies indicate that tribbles homolog 1 (Drosophila) protein (TRIB1) interacts with the master molecule of Tregs, forkhead box P3 (FOXP3 (show FOXP3 ELISA Kits)), a transcription factor essential for Treg suppressive activity.
Studies indicate that tribbles homolog 1 (Drosophila) protein (tribbles-1; TRIB1) is an important modulator of human energy metabolism and metabolic syndromes.
The Liver Clock Controls Cholesterol Homeostasis through Trib1 Protein-mediated Regulation of PCSK9 (show PCSK9 ELISA Kits)/Low Density Lipoprotein Receptor (LDLR (show LDLR ELISA Kits)) Axis.
Deletion of hepatic Trib1 leads to increased C/EBPalpha (show CEBPA ELISA Kits) binding near upregulated lipogenic genes, as well as Trib1 itself.
TRIB1 and TRIB3 (show TRIB3 ELISA Kits) are more strongly expressed than TRIB2 (show TRIB2 ELISA Kits) in cumulus cells (CC) surrounding oocytes from preovulatory follicles than in CC of immature ones.
These data suggested that the modulation of TRIB1 expression affects hepatic lipogenesis and glycogenesis through multiple molecular interactions.
In gene knock-down experiments in macrophages using small interfering RNAs targeted to Trib1, it was observed that TNF-alpha (show TNF ELISA Kits) production was increased following treatment with IFN-gamma (show IFNG ELISA Kits) and/or TLR2 (show TLR2 ELISA Kits) ligands.
These results indicate that COP1 and Trib1 act as an oncoprotein complex functioning upstream of C/EBPalpha (show CEBPA ELISA Kits), and its ligase activity is crucial for leukemogenesis.
tribbles-1 is a novel binding partner of Foxp3 (show FOXP3 ELISA Kits) in regulatory T cells
results demonstrate that Trib1 is critical for adipose tissue maintenance and suppression of metabolic disorders by controlling the differentiation of tissue-resident M2-like macrophages
Trib1-knockout mice showed elevated levels of plasma TG and cholesterol due to increased VLDL production.
Trib1 transduced hematopoietic stem cells developed acute myeloid leukemia (show BCL11A ELISA Kits).
a nuclear factor\; gene expression induced by m1-acetylcholine receptor
tribbles homolog 1 (Drosophila)
, G-protein-coupled receptor induced protein
, phosphoprotein C8FW
, tribbles homolog 1
, G-protein-coupled receptor-induced gene 2 protein
, G-protein-coupled receptor-induced protein 2
, phosphoprotein regulated by mitogenic pathways
, tribbles-like protein 1
, G-protein-coupled receptor induced protein GIG2